Some Cardiovascular Effects of the Aqueous Extract of the Leaves of Stachytarpheta jamaicensis L. Vahl

Idu, MacDonald; Omogbai, Eric K. I.; ., F. Amaechina; ., J.E. Ataman

doi:10.3923/ijp.2006.163.165

Cited by 9 publications

(4 citation statements)

References 5 publications

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“…According to the research done by Idu et al [32], it was concluded that the aqueous extract of S. jamaicensis demonstrated a significant dose-dependent antihypertensive effect. The extract reduced blood pressure and heart rates of anaesthetised rabbits, gradually in increasing doses, and the maximum effect was with the highest doses [32].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

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Stachytarpheta jamaicensis (L.) Vahl: From Traditional Usage to Pharmacological Evidence

Liew

Yong

2016

Evidence-Based Complementary and Alternative Medicine

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Introduction. Stachytarpheta jamaicensis (L.) Vahl belongs to the family of Verbenaceae and is commonly known as Gervao, Brazilian tea, verbena cimarrona, rooter comb, or blue porter weed. It is one of the important plants with high medicinal and nutraceutical benefits. S. jamaicensis contains various medicinal properties in traditional and folk medicinal systems, with cures for several diseases. Objective. The objective of this review paper is to collect information concerning the morphology, distribution, traditional usage, phytochemical compositions, biological activities, and safety data of S. jamaicensis. Materials and Methods. The information was obtained from literature search through electronic databases such as PubMed and Google Scholar on S. jamaicensis. Results and Conclusion. The high medicinal properties of this plant, for instance, antimicrobial and antifungal effect as the main activities, but verbascoside as the main active chemical component, make it a valuable source of the medicinal compound. This review paper summarizes all information concerning the morphology, distribution, traditional usage, phytochemical compositions, pharmacological activities, and toxicological studies of S. jamaicensis.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

“…The extract reduced blood pressure and heart rates of anaesthetised rabbits, gradually in increasing doses, and the maximum effect was with the highest doses [32]. …”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Stachytarpheta jamaicensis (L.) Vahl: From Traditional Usage to Pharmacological Evidence

Liew

Yong

2016

Evidence-Based Complementary and Alternative Medicine

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“…[ 9 ] Stachytarpheta cayennensis has been reported to be antiinflammtory, antinociceptive, anti ulcerogenic,[ 8 10 11 ] antidiarrheoal[ 12 ] as well as sedative[ 13 ] and hypotensive. [ 14 ] An insignificant in vitro antiplasmodial activity has been reported of the plant in Peru. [ 5 ] The aim of the present study was to evaluate the in vivo antiplasmodial potential of Stachytarpheta cayennensis considering its wide acceptability as malarial remedy in southern Nigeria.…”

Section: Introductionmentioning

confidence: 99%

In vivo antimalarial activity of ethanolic leaf extract of Stachytarpheta cayennensis

2008

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Objective:To evaluate the in vivo antiplasmodial activity of the ethanol leaf extract of Stachytarpheta cayennensis in the treatment of various ailment in Niger Delta region of Nigeria, in Plasmodium berghei infected mice.Materials and Methods:The ethanolic leaf extract of Stachytarpheta cayennensis (90-270 mg/kg/day) was screened for blood schizonticidal activity against chloroquine sensitive Plasmodium berghei berghei in mice. The schizonticidal effect during early and established infections was investigated.Result:Stachytarpheta cayennensis (90-270 mg/kg/day) exhibited significant (P< 0.05) blood schizonticidal activity both in 4-day early infection test and in established infection with a considerable mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day.Conclusion:The leaf extract possesses significant (P< 0.05) antiplasmodial activity which confirms it's use in folkloric medicine in the treatment of malaria.

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“…Notably, an aqueous A. altilis leaf extract decreased the tension of isolated guinea pig aorta rings stimulated with phenylephrine, supporting its apparent antagonism of the α1-adrenoreceptor [24]. In the case of S. jamaicensis, aqueous leaf preparations decreased blood pressure and heart rate in anaesthetized normotensive male rabbits -presumably due to negative-chronotropism or a direct effect on vascular smooth muscle [46] -and produced a decrease in plasma sodium concentrations and an increase in plasma potassium concentrations in normal rabbits [47]. These effects might partly be attributed to the glycoside verbascoside in the leaf [48] that stimulated the formation of the vasodilating eicosanoid prostacyclin from arachidonic acid [49].…”

Section: Discussionmentioning

confidence: 81%

Effects of plants with presumed cardiotonic properties on the decreased contractility of isolated guinea pig atria caused by acetylcholine: Implications for their clinical usefulness

Dennis R.A. Mans,

Rouafsa F. Joemmanbaks,

Walther Jap Tjoen San

2024

World J. Bio. Pharm. Health Sci.

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Heart failure (HF) has been related to a chronic imbalance between autonomic sympathetic and parasympathetic activation. In the Republic of Suriname (South America), this condition is regularly treated with plant-derived preparations with presumed cardiotonic properties, mostly by traditional healers. In this study, aqueous extracts from Annona muricata (leaf), Mansoa alliacea (leaf), Momordica charantia (leaf and stem), Gossypium barbadensis (leaf), Artocarpus altilis (leaf), Chrysophyllum cainito (leaf), Solanum melongena (unripe fruit), and Stachytarpheta jamaicensis (leaf and stem) were evaluated at serial dilutions for their capability to reverse the decreased contractility and for their effects on the decreased beating frequency of isolated guinea pig atria caused by EC50 acetylcholine (10-7 M). The effects of the plant extracts alone were also investigated. Experiments were for 3 min with 2 x 2-min intervals in Ringer-Locke buffer, 100% O2, and 30 °C. Results (g/sec and beats/min, means ± SDs; n ≥ 3) were expressed relative to those found with acetylcholine alone or buffer alone, and compared for statistically significant differences using one-way ANOVA (p < 0.05). None of the extracts reversed the decreased contractility and beating frequency of the atria caused by acetylcholine, but those from M. alliacea (0.001 mg/mL) and S. melongena (0.001 and 0.01 mg/mL) lowered these activities by more than 50%. The latter extracts exerted similar effects on their own. Thus, the preparations did not display useful cardiotonic properties against parasympathetic abnormalities in HF, and those from M. alliacea and S. melongena might even be cardiotoxic, warranting care when they are medicinally used.

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Some Cardiovascular Effects of the Aqueous Extract of the Leaves of Stachytarpheta jamaicensis L. Vahl

Cited by 9 publications

References 5 publications

Stachytarpheta jamaicensis (L.) Vahl: From Traditional Usage to Pharmacological Evidence

Stachytarpheta jamaicensis (L.) Vahl: From Traditional Usage to Pharmacological Evidence

In vivo antimalarial activity of ethanolic leaf extract of Stachytarpheta cayennensis

Effects of plants with presumed cardiotonic properties on the decreased contractility of isolated guinea pig atria caused by acetylcholine: Implications for their clinical usefulness

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