Some Biochemical Effects of Sub-Acute Oral Administration of L-Arginine on Monosodium Glutamate-Fed Wistar Albino Rats 2: Serum Alkaline Phosphatase, Total Acid Phosphatase and Aspartate Aminotransferase Activities

Quality Assessment of Waterside River, Ogbor Hill Aba 4: Effect of Three-Point Samples on Hepatic Histo-Morphology and Some Seric Bio-Functional Indicators of Wistar Rats

“…In particular, higher serum AST:ALT ratio greater than the control by one and above indicated cirrhosis (hardening) of major/high metabolic organs in rats [20,21] . Thus, the calculated serum ALT:ALP ratio greater than that of the control by one and above could be confirming the implication of damaged liver (and not that of other high metabolic organs) as responsible for the increased ALT activity in the serum while AST:ALP ratio of greater than one compared to the control could be confirmed that increased AST activity resulted from damage to other major organs.…”

“…This was based on the optimized standard method as described [18] . Serum aspartate aminotransferase (AST) activity and alanine aminotransferase (ALT) activity were determined by the method of Reitman and Frankel [19] as earlier described earlier [20,21] . This was based on the principle that oxaloacetate or pyruvate respectively reacts with chromogen (2,4-dinitrophenyhydrazine) in an alkaline medium to form coloured hydrazone that is proportional in concentration (as measured from the colour intensity) to the aspartate aminotransferase or alanine aminoteransferase activity.…”

“…The calculation of change relative to control was as developed earlier [22] and severally used [21,[23][24][25][26][27][28] . Change relative to control was calculated using the relation: …”

Dysfunctional Liver and other High Metabolic Organs in Asymptomatic Petroleum Depot Workers in Calabar South-South, Nigeria

“…The higher (p<0.05) aspartate amino transferase (AST) activity observed in the exposed group as against the control agrees with the report of Nwanjo and Ojiako (2007) for petrol station workers. Amino transferase (AST) enzyme is not liver specific, thus this could be a pointer to damaged high metabolic organs, aside the liver (Egbuonu et al, 2010a).…”

“…Liver function markers viz: serum ALT, AST, ALP and GGT activity, total and conjugated bilirubin concentration and their corresponding diagnostic ratios, including that of AST:ALT, ALT:AST, ALT:ALP, TB:CB and CB:TB, have been used to assess the physiological status in animals (Siddiqi et al, 2007;Egbuonu, 2010;Egbuonu et al, 2010aEgbuonu et al, , b, 2012Hyder et al, 2013). The results of the present study aside contributing to previous knowledge may form a basis for further studies on the subject.…”