Some biochemical effects of sub-acute oral administration of L-arginine on monosodium glutamate-fed Wistar albino rats 1: body weight changes, serum cholesterol, creatinine, and sodium ion concentrations

Egbuonu, Anthony Cemaluk C.; Obidoa, Onyechi; Ezeokonkwo, C. A.; Ejikeme, Paul M.; Ezeanyika, L. U. S.

doi:10.1080/02772240903450645

Cited by 29 publications

(10 citation statements)

References 13 publications

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“…Compromised function of VLDL is a risk factor for arteriosclerosis (Ochei and Kolhatkar, 2008) by impairing lipid metabolism. Impaired lipid metabolism resulting in higher total cholesterol and triacylglycerol concentrations in the serum may predispose animals to cardiac diseases (Egbuonu et al, 2010b;Uboh et al, 2005). This could imply cardiac dysfunction risk in the depot workers.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Risks and Impaired Lipid Metabolism in Asymptomatic Petroleum Depot Workers in Calabar Metropolis, Nigeria

Egbuonu¹,

Nkwazema²,

Ezeanyika³

2015

Research J. of Environmental Sciences

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The health concerns about working in a petroleum depot without wearing a Personal Protective Equipment (PPE) warranted this study. The anthropometric, lipid profile and blood pressure status were assessed by standard methods in asymptomatic adult male depot workers (n = 64) and male university students (n = 64), in Calabar metropolis, Nigeria. The concentration (mmol LG 1 ) of total cholesterol (5.21±0.90), triacylglycerol (1.23±0.20) and very low density lipoprotein (0.56±0.19) respectively in the serum of the depot workers were significantly (p<0.05) higher than in the control (5.09±0.04, 1.15±0.04 and 0.52±0.09). The body weight (73.75±0.11 kg), height (1.72±0.1 m) and body mass index, BMI, (24.58±0.73 kg mG 2 ) of the depot workers were higher (p>0.05) than that of the control. The Blood Pressure (BP) of the exposed group (120/90±1.38 mmHg) and the control (120/80±1.14 mmHg) differed only in the Diastolic Blood Pressure (DBP) by 10 mmHg and in the calculated systolic to diastolic blood pressure ratio (SBP:DBP) by 0.17. The study suggested cardiovascular risks and impaired lipid metabolism in the petroleum depot workers. The health implications of this study warrant a follow up perhaps, in a larger population and sample size. The study underscored the need for the petroleum depot workers to wear personal protective equipment and to assess their health status on a regular basis.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular Risks and Impaired Lipid Metabolism in Asymptomatic Petroleum Depot Workers in Calabar Metropolis, Nigeria

Egbuonu¹,

Nkwazema²,

Ezeanyika³

2015

Research J. of Environmental Sciences

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“…The addition of monosodium glutamate (MSG), to mimic the natural flavour of the non-essential amino acid, glutamate, to most commercially processed foods could be extensive with possible threat to public health [1][2][3][4][5][6]. Health hazards of MSG could result to oxidative stress in animals [3,[7][8][9][10][11][12][13]. And, oxidative…”

Section: Introductionmentioning

confidence: 99%

Monosodium Glutamate Plus Artemether-lumefantrine Overdose Altered Malondialdehyde, Total Protein and Albumin Concentration in Rats

et al. 2019

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This study aimed at assessing alterations in malondialdehyde, MDA, total protein and albumin concentration in the serum and liver homogenate of monosodium glutamate (MSG)-challenged rats co-treated with artemether-lumefantrine, AL. Methods involving colourimetric estimation were employed in thirty rats randomly grouped into six (n = 5) and for seven consecutive days, fed feed and water (Group A), AL therapeutic dose (Group B), AL overdose (therapeutic dose × 5) (Group C), MSG (8000 mg/kg body weight) (Group D), AL therapeutic dose plus MSG (Group E) or AL overdose plus MSG (Group F). Total protein concentration (2.64±0.09 g/dL, 2.81±0.14g/dL, respectively) in the liver homogenate of rats exposed to MSG (group D) or MSG plus AL overdose (group F) and malondialdehyde concentration in the liver homogenate of MSG plus AL overdose-fed rats (0.45±0.04 mg/ml) lowered (P<0.05) as against other groups. However, serum albumin concentration in MSG (2.59±0.13 g/dl) or AL overdose plus MSG (3.24±0.12 g/dl) fed rats was higher (P<0.05) compared to the control (2.02±0.04 g/dl). The Total protein: Albumin ratio lowered while the Albumin: total protein ratio increased in rats in MSG, AL overdose plus MSG or AL overdose groups compared with the control. Thus, the apparent MSG plus AL overdose-induced adverse influence on the studied parameters and samples of non-malarial infested rats could be via compromised liver-mediated protein metabolism capacity and bio-functions following possibly enhanced protein-malondialdehyde adduct formation in the rats.

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“…The calculation of change relative to control was as developed earlier [22] and severally used [21,[23][24][25][26][27][28] . Change relative to control was calculated using the relation: …”

Section: Calculation Of Some Diagnostic Ratios and Change Relative Tomentioning

confidence: 99%

Quality Assessment of Waterside River, Ogbor Hill Aba 4: Effect of Three-Point Samples on Hepatic Histo-Morphology and Some Seric Bio-Functional Indicators of Wistar Rats

Egbuonu¹,

Atasie²,

Onyeabo³

et al. 2018

International Journal of Research in Environmental Science

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Some biochemical effects of sub-acute oral administration of L-arginine on monosodium glutamate-fed Wistar albino rats 1: body weight changes, serum cholesterol, creatinine, and sodium ion concentrations

Cited by 29 publications

References 13 publications

Cardiovascular Risks and Impaired Lipid Metabolism in Asymptomatic Petroleum Depot Workers in Calabar Metropolis, Nigeria

Cardiovascular Risks and Impaired Lipid Metabolism in Asymptomatic Petroleum Depot Workers in Calabar Metropolis, Nigeria

Monosodium Glutamate Plus Artemether-lumefantrine Overdose Altered Malondialdehyde, Total Protein and Albumin Concentration in Rats

Quality Assessment of Waterside River, Ogbor Hill Aba 4: Effect of Three-Point Samples on Hepatic Histo-Morphology and Some Seric Bio-Functional Indicators of Wistar Rats

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