Some Biochemical Aspects of the Protective Effect of Strontium Chloride on Gamma-Irradiated Rats

Fahim, Fawzia A.; Yousri, R. M.; Roushdy, H.M.; Abady, M. I.

doi:10.1080/10256019108622556

Cited by 1 publication

(2 citation statements)

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“…The variation in transaminases activities may be due to certain damage in some tissue like heart, liver, kidney and skeletal muscles. Fahim et al mentioned that whole body gamma radiation of rats showed significant changes in the activities of transaminases which are dependent on the time lapses after irradiation and the type of tissue containing the enzyme [59]. These results may be attributed to the state of hypoxia of parenchyma for contracting fibrous tissue and the increased permeability of hepatic cell membrane due to irradiation exposure with release of ALT enzyme to circulation.…”

Section: Discussionmentioning

confidence: 99%

“…Animals receiving AGE at doses of 25 and 50 mg / kg, showed a significant decrease (P < 0.001), in aspartate transaminase levels compared to the group "Irradiation + Distilled Water " (Figure 3). This decrease is respectively in order of 59 Similarly, compared to the group "Irradiation + Vitamin E and Lipoïc Acid" a significant decrease (p < 0.01) was observed in the group "Irradiation + 25 mg / kg AGE" in order of 34.97% (76.6±6.72 Vs 117.8±7.96 U/L) and a nonsignificant decline (P > 0.05) in the group "Irradiation + 50 mg / kg AGE" in order of 9.34% (106.8±8.32 Vs 117.8±7.96 U/L). Each bar represents the Mean±ESM, (n = 5: number of animals in each group).…”

Section: Aspartate Transaminase (Ast)mentioning

confidence: 91%

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Protective Effect of Aged Garlic Extract Against the Oxidative Stress Induced by Acute Ionizing Irradiation on Hepatic Antioxidant Enzymes in Rats

Bertrand¹,

Pascal²,

Désiré³

et al. 2016

EJCBS

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Ionizing radiations damage cells, tissues and organs among which the liver through a cascade of molecular events that are triggered by reactive oxygen species (ROS), lipid peroxidation and nitrogen species (NS). Aged Garlic Extract (AGE) has been demonstrated to possess free radical scavenging capacity and antioxidant activity. Therefore, the present study has been focused in analyzing the properties of AGE against the lipid peroxidation and oxidative damages of rat liver tissues induced by acute radiation. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. Then, biochemical analyses, lipid peroxidation, total Protein and antioxidants assessment were made from blood samples and liver tissue homogenates. Exposure of rats to gamma radiation caused a significant increase in the level of Malondialdehyde, Nitrite, transaminase enzymes, alkaline phosphatase, and Bilirubin (Total Serum Bilirubin, Direct Bilirubin and Unconjugated Bilirubin) level while a significant decrease was recorded in serum total proteins, glutathione content, superoxide dismutase, catalase activities and total protein level. AGE treated rats revealed a significant improvement in all previous parameters. From these results, it can be concluded that AGE may have significant anti-radiation properties in rat's liver after radiation exposure.

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Section: Discussionmentioning

confidence: 99%

Section: Aspartate Transaminase (Ast)mentioning

confidence: 91%