Some Bioactivities of Heterocyclic Compounds Containing Pyrazoline Moiety A Short Review

Ardiansah, Bayu

doi:10.20902/ijctr.2018.111004

Cited by 4 publications

(5 citation statements)

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“…Pyranopyrazole-benzothiazole and oxadiazole compounds (23 & 24) were synthesized by one-pot methodology to achieve 81-91 % yield of products. Compound (23) with methylsubstituted gave excellent antimicrobial properties followed by methoxy and hydroxy-substituted compounds also showed better activities against S. aureus, B. subtilis, P. vulgaris, E. coli, A. niger and A. flavus. [178,179] Moreover compound (24) exhibited antioxidant activities, EDG compounds (24) at para position confirmed higher antioxidant activity as compared to orthosubstituted compounds.…”

Section: Synthesis Of Pyranopyrazoles Via Ethyl Acetoacetate Derivativesmentioning

confidence: 99%

“…[5,6] It has other alternative names such as pyrano [2,3c]pyrazoles, 4H-pyrano [2,3-c]pyrazoles and also 1,4dihydropyrano [2,3-c]pyrazol-5-yl cyanides. [7,8] Pyranopyrazole is a bioactive moiety [9] that has numerous applications in pharmaceuticals and agrochemicals, herbicide, fungicide, [10] insecticide, [11] larvicidal, [12] and biological activities i. e., antibacterial, [13][14][15] antimicrobial, [16] anticancer, [17][18][19][20] antitubercular, [21] antiallergenic, [22] antioxidant, [23,24] antineoplastic, [25] , anti-inflammatory, [26] and human Chk1 kinase inhibitor activities (Figure 2). [3,[27][28][29] The stability of pyranopyrazoles depends on substituent rings and intermolecular hydrogen bonding interactions between the molecules.…”

Section: Introductionmentioning

confidence: 99%

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Recent Synthesis of Mono‐ & Bis‐Pyranopyrazole Derivatives

Farooq,

Ngaini

2024

ChemistrySelect

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Recent Synthesis of Mono‐ & Bis‐Pyranopyrazole Derivatives. Pyranopyrazole is an important structural unit in heterocyclic chemistry and is useful in pharmaceutical and agrochemical industries. The pyranopyrazole‐based compounds are known in the agricultural industry as herbicides, fungicides, and insecticide agents and in medicinal fields as antimicrobial, anticancer, and antiHIV agents. Despite its wide range of applications, the synthesis of pyranopyrazole has several limitations such as the cost of reagents, potential environmental risks, harsh reaction conditions, longer reaction times, laborious workup procedures, and unsatisfactory yields. However, many studies have been recently reported on the synthesis of pyranopyrazoles using mild, green, and environmentally friendly methods that also give higher yields. Different catalysts and conditions have been reported for the synthesis of pyranopyrazole using four, three, and two components. Among these, four‐component synthesis is commonly reported by using benzaldehyde, hydrazine derivatives, ethyl acetoacetate and malononitrile due to the commercial availability and stability of the reagents. This review summarized the recent synthesis of pyranopyrazole i. e., mono‐ and bis‐pyranopyrazole derivatives via four‐, three‐ and two‐component‐based reactions. Mono‐ and bis‐pyranopyrazole derivatives varied due to the number of pyranopyrazole units that contributed to play an important role in increasing the binding interaction and biological activities beneficial for pharmaceutical industries.

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Section: Synthesis Of Pyranopyrazoles Via Ethyl Acetoacetate Derivativesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Synthesis of Mono‐ & Bis‐Pyranopyrazole Derivatives

Farooq,

Ngaini

2024

ChemistrySelect

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“…Numerous preceding review articles have appropriately lauded the progress in pyranopyrazole synthesis through MCRs, 27,28 showcasing ingenious strategies, high yields, and novel applications. In this landscape, our review article aims to stand apart by offering a fresh perspective on the synthesis of pyranopyrazoles through MCRs, one that prioritizes the principles of green chemistry.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the one-pot nature of this reaction reduces the number of purication steps required, minimizing potential side reactions and simplifying the overall synthetic process. 25,26 Numerous preceding review articles have appropriately lauded the progress in pyranopyrazole synthesis through MCRs, 27,28 showcasing ingenious strategies, high yields, and novel applications. In this landscape, our review article aims to stand apart by offering a fresh perspective on the synthesis of pyranopyrazoles through MCRs, one that prioritizes the principles of green chemistry.…”

Section: Introductionmentioning

confidence: 99%

Green multicomponent synthesis of pyrano[2,3-c]pyrazole derivatives: current insights and future directions

Ahmad,

Rao,

Shetty

2023

RSC Adv.

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“…Pyrazolines have well-established therapeutic benefits for neurodegenerative diseases. − The present investigation considered the beneficial effects of pyrazolines reported since 2003 on certain neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and psychiatric disorders. AD is one of the most common neurodegenerative disorders in elderly people and accounts for more than 80% of the world’s cases of dementia .…”

Section: Introductionmentioning

confidence: 99%

Pyrazoline Containing Compounds as Therapeutic Targets for Neurodegenerative Disorders

Ahsan¹,

Ali

et al. 2022

ACS Omega

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Pyrazolines are a significant class of heterocyclic compounds with essential biological activities. They are quite stable, which has inspired medicinal chemists to experiment with the ring's structure in many different ways to create a variety of pharmacological activities. The structures of numerous commercially available therapeutic agents contain a pyrazoline ring. Pyrazolines are well-known for their ability to treat neurodegenerative diseases. The neurodegenerative diseases that affect huge populations globally include Alzheimer's disease (AD), Parkinson's disease (PD), and psychiatric disorders. The neuroprotective properties of pyrazolines published since 2003 are covered in the current review. Structure−activity relationships (SARs), molecular docking simulation, anticholinesterase (anti-AChE), and monoamine oxidase (MAO A/B) inhibitory actions are all covered in this article. Pyrazolines were discovered to have beneficial effects in the management of AD and were revealed to be inhibitors of acetylcholine esterase (AChE) and beta-amyloid (A β ) plaques. They were discovered to be efficient against PD and also targeted MAO B and COMT. It was discovered that the pyrazolines block MAO A to treat psychiatric diseases. Pyrazolines are significant heteroaromatic scaffolds with a variety of biological functions. They were discovered to be remarkably stable and serve as an indispensable anchor for the development of new drugs. By blocking AChE and MAOs, they may be used to treat neurodegenerative diseases. The discussion outlined here is an essential and helpful resource for medicinal chemists who are investigating and applying pyrazolines in neurodegenerative research initiatives as well as to expedite future research programs on neurodegenerative disorders.

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Some Bioactivities of Heterocyclic Compounds Containing Pyrazoline Moiety A Short Review

Cited by 4 publications

References 10 publications

Recent Synthesis of Mono‐ & Bis‐Pyranopyrazole Derivatives

Recent Synthesis of Mono‐ & Bis‐Pyranopyrazole Derivatives

Green multicomponent synthesis of pyrano[2,3-c]pyrazole derivatives: current insights and future directions

Pyrazoline Containing Compounds as Therapeutic Targets for Neurodegenerative Disorders

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