Some aspects of the negative ion mass spectrometry of complex organic molecules

Alexander, F.G.; Bigley, D. B.; Todd, John F. J.

doi:10.1016/0042-207x(74)90035-9

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…Fragmentation is also a problem of EC-MS. Although fragmentation in EC yields more specific ions than in positive ionization modes, interpretation of mass spectra is difficult especially for unknown compounds [13]. Furthermore, the ionization parameters do not eliminate the possibility of other ionization reactions [12,14].…”

Section: Introductionmentioning

confidence: 99%

New derivatization strategies for the ultrasensitive analysis of non-aromatic analytes with APLI-TOF-MS

2015

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Atmospheric pressure laser ionization (APLI) (Constapel et al. in Rapid Commun Mass Spectrom 19:326-336, 2005; Schiewek et al. in Anal Chem 79:4135-4140, 2007; Schmitz and Benter (2007) J Chromatography Library 72:89-114) is an ultra-sensitive and selective ionization method for the determination of polycyclic aromatic compounds. The selectivity is an advantage but also a disadvantage. To overcome the limitation of APLI to aromatic compounds, we have already reported some derivatization strategies for common organic functional groups (Schiewek et al. in Angew Chem Int Ed 47:9989-9992, 2008). Here, we describe the synthesis of new APLI ionization labels and their use in new derivatization strategies. These new labels widen the range of APLI-(TOF)MS analysis to non-aromatic compounds with the most common functional groups such as amines, alcohols and carboxylic acids to gas chromatography (GC) and lower the limits of detection (LOD) down to concentrations as small as pmol/L and attomole on column.

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Section: Introductionmentioning

confidence: 99%

New derivatization strategies for the ultrasensitive analysis of non-aromatic analytes with APLI-TOF-MS

2015

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The formation and fragmentation of negative ions derived from organic molecules

Bowie

1984

Mass Spectrometry Reviews

129

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Einfluß der chemischen Struktur auf die EA‐Massenspektren von aromatischen Kohlenwasserstoffen sowie von N‐ und S‐Heteroanaloge

Albers

Knof

1977

Org. Mass Spectrom.

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The dependence of fragmentation pattern and ion intensity on chemical structure is investigated for aromatic hydrocarbons with molecular weights greater than 100 (and their nitrogen and sulfur analogues) by electron attachment mass spectrometry. The yield of negative ions is influenced by chemical structure predominantly and is not greatly influenced by the presence of heteroatoms. One exception to this rule is the formation of a very high yield of molecular ions from sulfides.

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Some aspects of the negative ion mass spectrometry of complex organic molecules

Cited by 5 publications

References 14 publications

New derivatization strategies for the ultrasensitive analysis of non-aromatic analytes with APLI-TOF-MS

New derivatization strategies for the ultrasensitive analysis of non-aromatic analytes with APLI-TOF-MS

The formation and fragmentation of negative ions derived from organic molecules

Einfluß der chemischen Struktur auf die EA‐Massenspektren von aromatischen Kohlenwasserstoffen sowie von N‐ und S‐Heteroanaloge

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