Some Aspects of the Effect of Ionizing Radiation on Tumors in Experimental Animals

Dose‐dependent recognition of irradiated isogeneic mouse lymphoma cells: Study by terminal dilution assay

“…The present results are clearly relevant to the problem of extrapolating from data obtained under idealized in vitro conditions to tumor cell behavior in vivo. Cell response in the intact animal may be far more complex for a variety of reasons which include host resistance (Scott, 1958;Maruyama, 1967Maruyama, , 1968) and related factors. Indirect effects which alter cell response in vivo provide a means of increasing the therapeutic efficacy of a n agent akin to antibiotic killing of bacteria in infection, and provide more efficient inacthation of antigenically distinctive tumor cells.…”

Cancer immunology and radiobiology: Oliver Scott’s struggle for the perfect tumour model in translational research

“…And "If, for instance, 99% of the cells of a large inoculum are killed by radiation, small differences in the histocompatibility genes of tumour and host may account for the failure of the remaining 1% to grow. " 2 Soon after, these ideas were validated by the work of H.D. Suit in Houston and H. Hewitt in ICRF London.…”

“…1 Yet no less important were Oliver's activities in the development of concepts and methods for performing translational research on the "effect of ionising radiation on tumour in experimental animals", to quote the title of one of his longest papers which he wrote only few years after his most famous early study which established hyperbaric oxygen as effective method to overcome the radioresistance of hypoxic tumours. 2…”

“…He stated clearly that it is not the early pathological radiation effect that matters but the delayed "loss of reproductive integrity" of what we call today tumour stem cells which determines the therapeutic success. 2 He extensively discussed also the critical role of residual immunity abstract Oliver Scott is best known for his research into the role of tumour hypoxia in radiation oncology. Yet no less important were Oliver's activities in the development of concepts and methods for performing translational research on the effect of ionising radiation on tumour in experimental animals, stressing the importance of using strictly inbred animals for transplantation of tumours which had arisen in exactly the identical mouse strain.…”

Oliver Scott (1922–2016)

“…The turning point came in 1952. Hal Gray and his young doctors explored the potential impact of the long known oxygen effect in radiotherapy [2,3,5]. In an unpublished manuscript dated October 10, 1952, Hal Gray describes new experimental results on the dependence of radiosensitivity on the oxygen concentration in plants, germ cells of the fruit fly and insect larvae, concluding that oxygen dissolved in cells ''affect only the early pathway peculiar to the radiationinduced lesion" and further ''by raising the O2 tension throughout the body sufficiently, a gain of about a factor of 2 could be obtained in respect of portions of tumour which are effectively anoxic .…”