Some aspects of renal function in the newly born

Wilkinson, A. W.

doi:10.1016/s0022-3468(73)80074-0

Cited by 13 publications

(8 citation statements)

References 12 publications

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“…Statistical com parisons were made by chi-square comparison VOL. 7 [11]. Values were expressed as the mean ± standard error of the mean (SEM).…”

Section: Statistical Evaluationmentioning

confidence: 99%

“…They sustained renal losses of Mg as a result of acidosis [17] and theophylline [18] and furosemide [18] therapy. Emesis, nasogastric suction, and frequent stooling can cause major gastrointestinal losses of Mg [6,7,16]. Finally, the cardiorespiratory cri ses experienced by the sickest infants resem bled the seizure-shock episodes of Mg deficient weanling animals in terms of physical, bio chemical, and electrocardiographic changes [19]; and the structural changes of RDS resem ble the changes found in the lungs of these animals [20].…”

Section: Suspecting and Diagnosing Mg Deficiency In This Populationmentioning

confidence: 99%

“…Two common medi cal problems, acidosis and hypoxemia, increase plasma Mg [21]. The parenteral Mg load test is reliable after the first month, when the kidney has sufficiently matured [7,22].…”

Section: Suspecting and Diagnosing Mg Deficiency In This Populationmentioning

confidence: 99%

“…Mg is ex creted by the kidneys; glomerular filtration rate [7] and tubular function [24] are reduced during the first month of life. The renal function of the premature infant with RDS [25] may be further reduced.…”

Section: The Duration and Potential Danger Of Mg Supplementationmentioning

confidence: 99%

“…Supplementary Mg has been associated with striking improvement in infants with seizures, apnea, cardiac distur bances, who showed evidence of Mg deficiency [4][5][6][7][8][9]. This is a retrospective review of hospital and follow-up experiences of 200 premature neo nates with idiopathic apnea neonatorum, 93% of whom also had RDS.…”

Section: Introductionmentioning

confidence: 99%

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Magnesium therapy in premature neonates with apnea neonatorum.

Caddell

1988

Journal of the American College of Nutrition

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Apnea, bradycardia, and neuromuscular hyperirritability have been associated with magnesium (Mg) deficiency in young human infants and weanling animals. This is a retrospective review of a clinical experience of Mg therapy among 200 premature neonates who showed physical and clinical chemical changes compatible with Mg deficiency. The 200 infants all had idiopathic apnea neonatorum, and 93% also had the respiratory distress syndrome (RDS). This review was conducted to learn whether Mg therapy was associated with a significant reduction in apnea. The author suggested that the dose of Mg be 0.4 mEq/kg body weight/day, as 50% MgSO4.7H2O intramuscularly (IM) for 5 days; or as 1.0 mEq/kg/day, as 10% MgCl2.6H2O by mouth for 2 or more weeks, with appropriate monitoring of plasma Mg values in all infants. Sixty-one infants received a minimum of 5 days of Mg by either route (mean, 11.4 +/- 0.9, Group A); five received 3-4 doses IM (mean, 3.6 +/- 0.2, Group B); and 134 received 0-2 doses IM (0.5 +/- 0.1, Group C). Group A infants Mg-treated before Day 20 showed earlier cessation of apnea and bradycardia than those treated after Day 20. In Group A patients, 7 dose-days [corrected] of Mg therapy was associated with continuation of apnea; 14 dose-days [corrected], with cessation of apnea. Compared with Group A, Group C continued to develop apnea (P less than .003) and bradycardia (P less than 0.03) over longer periods of time. Group A infants showed no record of death or of hospital readmission for recurrent apnea, while 32 of 134 Group C infants had one or both of those unfavorable outcomes (P less than 0.001), with four of the five deaths in Group C (NS) as the sudden infant death syndrome (SIDS). In conclusion, Mg was associated with a reduction of apnea in this population. Emphasis was placed on the need to closely observe infants receiving supplementary Mg, with monitoring of plasma Mg levels.

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“…Statistical com parisons were made by chi-square comparison VOL. 7 [11]. Values were expressed as the mean ± standard error of the mean (SEM).…”

Section: Statistical Evaluationmentioning

confidence: 99%