Some aspects of diagnosis and treatment of cough

The article is devoted to the use of mucolytic therapy in the treatment of infectious and inflammatory diseases of the respiratory tract. Pathogen exposure results in an increase in the viscosity and adhesion of the respiratory tract mucus and leads to an impairment of drainage function and mucociliary clearance of the bronchi. Given the pathogenetic features, the primary goal of the treatment is to change the rheological properties of sputum and remove mucus from the respiratory tract. This justifies the administration of mucolytics, taking into account their pharmacological characteristics.

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Combination therapy for cough and bronchial obstruction in childhood

Мизерницкий¹,

Доровская

Мельникова

2019

Medicinskij sovet

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The inflammatory process in the bronchial mucosa of various origins (infectious, allergic, irritative, etc.) cause changes in the sputum production and its rheological properties, slowing of mucociliary clearance. Mucoactive therapy is one of the important components of the management of bronchopulmonary diseases. The article provides a detailed review of the modern literature, as well as the authors’ own experience regarding the cough therapy methods, including techniques used in the bronchial obstructive syndrome. The use of combination drugs, which simultaneously affect various pathogenetic mechanisms of inflammation and cough, including those in the respiratory diseases with bronchial obstructive syndrome, becomes a promising direction of mucoactive therapy. Due to relative safety and clinical efficacy, the modern combination therapy, including a fixed-dose combination of salbutamol, bromhexine, guaifenesin (Ascoril, Ascoril expectorant), is increasingly becoming the drug of informed choice in mild bronchial obstruction in childhood in pediatric practice.

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Some aspects of diagnosis and treatment of cough

Cited by 4 publications

References 5 publications

Cough as a sign of post-nasal drip syndrome

Cough as a sign of post-nasal drip syndrome

The use of mucolytic therapy in the treatment of infectious and inflammatory diseases of the respiratory tract

Combination therapy for cough and bronchial obstruction in childhood

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