Some Anti-Inflammatory Activities of Copper Complexes of Amino Acids

West, G. B.

doi:10.1159/000232807

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…A comparison was therefore made of the action of histidine (an inactive amino acid) with that of its copper complex in a series of tests. The histidine complex was first found to be a potent inhibitor of both the dextran and carrageenan oedema reactions in rats and then shown to be very active against erythema produced in rat skin by exposure to ultraviolet light (West 1981). Copper complexes of tryptophan and cysteine were similarly effective.…”

Section: -Hydroxytryptaminementioning

confidence: 99%

Forty Years of Pharmacological Research

West

1984

J R Soc Med

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Section: -Hydroxytryptaminementioning

confidence: 99%

Forty Years of Pharmacological Research

West

1984

J R Soc Med

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“…Several anticancer agents have been developed with numerous transition metals and screened for their antineoplastic properties. Cu(II) complexes have recently attracted attention, as they can be designed as anticancer agents in an effort to overcome the severe side effects of known drugs like cisplatin, bleomycin, etc. − Redox active compounds such as Cu(II) can cleave the phosphodiester backbone of DNA molecules and have a wide range of biological activities, and some of them have known antimicrobial, , antinflammatory, antiviral, and antitumor , activities. Several other compounds such as bleomycin, pyrrole, thioether, oxime, peptides, and imidazole type ligands, have been complexed with copper ions, exhibit DNA cleavage activities. , …”

Section: Introductionmentioning

confidence: 99%

DNA Binding Ability and Hydrogen Peroxide Induced Nuclease Activity of a Novel Cu(II) Complex with Malonate as the Primary Ligand and Protonated 2-Amino-4-picoline as the Counterion

et al. 2010

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The DNA binding property of a Cu(II) complex, viz., [Cu(mal)(2)](picH)(2).2H(2)O, (mal)(2) = malonic acid, picH = protonated 2-amino-4-picoline, has been investigated in this study. The binding of this complex with plasmid and chromosomal DNA has been characterized by different biophysical techniques. From the absorption and fluorescence spectroscopic studies, it has been observed that the said copper complex binds strongly with pUC19 plasmid and CT DNA with a binding affinity of 2.368 x 10(3) and 4.0 x 10(3) M(-1), respectively, in 10 mM citrate-phosphate buffer, pH 7.4. Spectrofluorimetric studies reveal that the copper complex exhibits partial DNA intercalation as well as partial DNA minor groove binding properties. Consequently, in agarose gel electrophoresis study, it has been observed that the complex alone induces positive supercoiling in plasmid DNA while in the presence of H(2)O(2) it exhibits nuclease activity. The induction of the breakage in DNA backbone depends upon the relative concentrations of H(2)O(2) and copper complex followed by the time of incubation with DNA. Optical DNA melting study, isothermal titration calorimetry, and absorption spectroscopy have been used to characterize the nuclease activity of this complex in the presence of H(2)O(2). Further, (1)H NMR study indicates that Cu(II) in the complex is converted into the Cu(I) state by the reduction of H(2)O(2). Finally, agarose gel electrophoresis study with different radical scavengers concludes that the production of both hydroxyl radicals and reactive oxygen species is responsible for this nuclease activity.

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Is copper pro- or anti-inflammatory? A reconciling view and a novel approach for the use of copper in the control of inflammation

Berthon

1993

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The anti-inflammatory role of copper is well-known although still largely unexplained. On the other hand, the capacity of copper to induce the formation of damaging .OH radicals in vivo is no longer debated. These two aspects of the physiological activity of copper have been considered to be paradoxical. Arguments developed here show that they may actually derive from a single chemical process, the type of physiological effect observed depending on the ligand bound to the copper ions involved in Fenton chemistry. Both iron and copper are Fenton catalysts. Given its intrinsic coordination properties, however, copper induces more site-specific .OH damage to the ligands bound to it. It, therefore, appears that copper complexes with specific .OH-inactivating ligands (OILs) can be used as "lures" for the Fenton reaction, .OH radicals preferentially formed on these being immediately inactivated. The hypothesis is thus put forward here that copper-OIL complexes acting as effective Fenton catalysts are potential "catalase-like" anti-inflammatory drugs.

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Some Anti-Inflammatory Activities of Copper Complexes of Amino Acids

Cited by 6 publications

References 4 publications

Forty Years of Pharmacological Research

Forty Years of Pharmacological Research

DNA Binding Ability and Hydrogen Peroxide Induced Nuclease Activity of a Novel Cu(II) Complex with Malonate as the Primary Ligand and Protonated 2-Amino-4-picoline as the Counterion

Is copper pro- or anti-inflammatory? A reconciling view and a novel approach for the use of copper in the control of inflammation

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