Some additional suggestions for an intervertebral disc prosthesis

Edeland, H. G.

doi:10.1016/0141-5425(85)90010-x

Cited by 26 publications

(9 citation statements)

References 2 publications

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“…The only clinical study was reported by Steffee 10 (6 cases), which showed that polymer shearing was not fit for the translation of the implant. Another concept is composite viscohydraulics, 9,12 but no clinical application has addressed the problem of durability of the hydraulic system.…”

Section: Discussionmentioning

confidence: 99%

Prosthetic Disc Nucleus (PDN) Replacement for Lumbar Disc Herniation

Jin

Zhao

et al. 2003

Spine

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A clinical follow-up study was performed to evaluate lumbar disc nucleus replacement clinically and functionally. The objective was to assess the clinical efficacy of the prosthetic disc nucleus (PDN) for treatment of lumbar disc herniation. The PDN was designed to treat patients suffering from disc herniation and/or degeneration. Clinical trials for PDN were first conducted in 1996, and the results showed that the PDN device was effective in most of the patients who were implanted. These studies had been carried out with patients who were implanted with a pair of the devices. The main complication was device migration. Therefore, a follow-up study based on a single PDN device implantation was designed to evaluate its clinical result. Forty-five patients with lumbar disc herniation were implanted with one PDN device from March 2002 to December 2002. Thirty (66.7%) patients came to the clinical, functional, and radiographic 6-month follow-up examinations. Independent analysis was performed by careful review of the charts, operative notes, preoperative and postoperative radiographs, magnetic resonance images, and follow-up records of all patients. After implantation, significant proportions of patients experienced pain relief. Improvements were noted in pain intensity, walking distance, lumbar mobility, neurologic weakness, Oswestry and Prolo scores, and intervertebral disc height. No difference in work status after PDN implantation could be detected. Compared with the preoperative height, the intervertebral disc had gained 19.7% (P < 0.001). Device migration, failure, and dislocation were not noticed in any patient. A few patients had minor complications such as transient low-grade fever. Clinically, a single PDN is preferred and can effectively increase the height of the intervertebral disc in patients with lumbar disc herniation. However, longterm follow-up of PDN implantation needs to be studied.

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Section: Discussionmentioning

confidence: 99%

Prosthetic Disc Nucleus (PDN) Replacement for Lumbar Disc Herniation

Jin

Zhao

et al. 2003

Spine

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“…Further, no suitable animal model exists for the reasonable investigation of spine implants, except for tissue acceptance, carcinogenicity, and biocompatibility, as was ethically performed in experiments using large dogs and goats. [10][11][12] Nevertheless, as is required by the FDA, a baboon study is currently under way.…”

Section: Highlightsmentioning

confidence: 99%

“…10 Magnetic resonance imaging sagittal views of a male patient, 6 months after PDN implant. The hydrated PDN closely resembles the appearance of a normal disk nucleus.…”

mentioning

confidence: 99%

161 Prosthetic Disc Nucleus: Concept and Clinical Outcome

Kim¹,

Vaccaro²,

Fessler³

2005

Spinal Instrumentation: Surgical Techniques

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“…The current surgical options for spinal disorders (e.g. intervertebral disc degeneration, general spine degeneration 2 ) are not very effective 3 . If conservative treatments fail, the gold standard remains spinal fusion after discectomy 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Minimally invasive photopolymerization in intervertebral disc tissue cavities

Schmocker

Khoushabi

Gantenbein

et al. 2014

Biomedical Applications of Light Scattering VIII

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Photopolymerized hydrogels are commonly used for a broad range of biomedical applications. As long as the polymer volume is accessible, gels can easily be hardened using light illumination. However, in clinics, especially for minimally invasive surgery, it becomes highly challenging to control photopolymerization. The ratios between polymerizationvolume and radiating-surface-area are several orders of magnitude higher than for ex-vivo settings. Also tissue scattering occurs and influences the reaction.We developed a Monte Carlo model for photopolymerization, which takes into account the solid/liquid phase changes, moving solid/liquid-boundaries and refraction on these boundaries as well as tissue scattering in arbitrarily designable tissue cavities. The model provides a tool to tailor both the light probe and the scattering/absorption properties of the photopolymer for applications such as medical implants or tissue replacements. Based on the simulations, we have previously shown that by adding scattering additives to the liquid monomer, the photopolymerized volume was considerably increased.In this study, we have used bovine intervertebral disc cavities, as a model for spinal degeneration, to study photopolymerization in-vitro. The cavity is created by enzyme digestion. Using a custom designed probe, hydrogels were injected and photopolymerized. Magnetic resonance imaging (MRI) and visual inspection tools were employed to investigate the successful photopolymerization outcomes.The results provide insights for the development of novel endoscopic light-scattering polymerization probes paving the way for a new generation of implantable hydrogels.

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Some additional suggestions for an intervertebral disc prosthesis

Cited by 26 publications

References 2 publications

Prosthetic Disc Nucleus (PDN) Replacement for Lumbar Disc Herniation

Prosthetic Disc Nucleus (PDN) Replacement for Lumbar Disc Herniation

161 Prosthetic Disc Nucleus: Concept and Clinical Outcome

Minimally invasive photopolymerization in intervertebral disc tissue cavities

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