Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients

Lijffijt, Marijn; Dam, P. Sytze van; Kenemans, J. Leon; Koppeschaar, H. P. F.; Vries, W. R. de; Drent, Madeleine L.; Wittenberg, Amanda; Kemner, Chantal

doi:10.1016/j.neulet.2003.09.028

Cited by 36 publications

(22 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In childhood or adult-onset GHD because of pituitary dysfunction, a decline in neurocognitive functionalities like cognition, memory, motivation, attention, and sleep, and overall quality of life (QoL) have been observed. GH replacement therapy showed significant improvements in these variables (254,285,286,287,288,289,290,291,292). Similar observations were also made following GH treatment in patients with Prader-Willi syndrome (293).…”

Section: Cognitive Studies In Humans With Ghr Deficiencysupporting

confidence: 69%

MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?

Basu

Qian

Kopchick

2018

European Journal of Endocrinology

View full text Add to dashboard Cite

Growth hormone (GH) is produced primarily by anterior pituitary somatotroph cells. Numerous acute human (h) GH treatment and long-term follow-up studies and extensive use of animal models of GH action have shaped the body of GH research over the past 40-50 years. Work on the GH receptor (R) knock-out (GHRKO) mice and results of studies on GH resistant Laron Syndrome (LS) patients have helped define many physiological actions of GH including those dealing with metabolism, obesity, cancer, diabetes, cognition, and aging/longevity. In this review, we have discussed several issues dealing with these biological effects of GH and attempt to answer the question of whether decreased GH action may be beneficial.

show abstract

Section: Cognitive Studies In Humans With Ghr Deficiencysupporting

confidence: 69%

MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?

Basu

Qian

Kopchick

2018

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Both have been associated with cognitive impairments in memory, attention/concentration (working memory), and information processing speed. (Baum et al, 1998;Deijen et al, 1996;Lijffijt et al, 2003;Peace et al, 1998;van Dam et al, 2005). Replacement of GH in persons with childhood-onset GHD has shown improvement in these cognitive domains (Arwert et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Effect of Growth Hormone Replacement Therapy on Cognition after Traumatic Brain Injury

High

Briones-Galang

Clark

et al. 2010

Journal of Neurotrauma

141

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is a major public health issue, and yet medical science has little to offer for the persistent symptoms that prevent many of these individuals from fully re-entering society. Post-traumatic hypopituitarism, and specifically growth hormone deficiency (GHD), has been found in a large percentage of individuals with chronic moderate to severe TBI. Presently, there are no published treatment studies of hormone replacement in this population. In this study, 83 subjects with chronic TBI were screened for hypopituitarism. Forty-two subjects were found to have either GHD or GH insufficiency (GHI), of which 23 agreed to be randomized to either a year of GH replacement or placebo. All subjects completed the study with no untoward side effects from treatment. A battery of neuropsychological tests and functional measures were administered before and after treatment. Improvement was seen on the following tests: Dominant Hand Finger Tapping Test, Wechsler Adult Intelligence Scale III-Information Processing Speed Index, California Verbal Learning Test II, and the Wisconsin Card Sorting Test (executive functioning). The findings of this pilot study provide preliminary evidence suggesting that some of the cognitive impairments observed in persons who are GHD/GHI after TBI may be partially reversible with appropriate GH replacement therapy.

show abstract

“…In young adults with childhood-onset GHD, existing data argue for reduced memory and, possibly, reduced attention (20)(21)(22). In patients with adult-onset GHD, the data are less consistent; the presence/severity of cognitive deficits seems to be determined by underlying cause and its treatment (23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Effects of GH on cognitive function in elderly patients with adult-onset GH deficiency: a placebo-controlled 12-month study

et al. 2007

View full text Add to dashboard Cite

Objective: Young adults with childhood-onset GH deficiency (GHD) have reduced memory and attention, which can be improved by treatment with GH. Little information is available on cognitive function in elderly GHD patients. Design: Single center, double-blind, randomized, placebo-controlled study of 52-week duration. Methods: Elderly GH therapy naïve GHD patients (nZ34; age range 60-77 years) were enrolled and randomized to receive placebo or GH therapy which was titrated to achieve a target IGF-I level of C1 to C2 S.D. of the normal mean for age. Cognitive function was assessed at baseline and after 24 and 52 weeks, using a computerized psychometric test package (Neurobehavioral Examination System-2). Results: The mean GH dose was 0.16G0.06 mg/day; mean IGF-I increased from 135G59 ng/ml at baseline to 213G77 ng/ml during active treatment. The GH-treated group had better mean serial digit learning scores compared with placebo group (P!0.05). Assessment of effect sizes showed that improvements in memory occurred with GH after 24 weeks. The overall adverse event rates were similar in the GH and the placebo group. Conclusion: This study indicates that GH replacement may be accompanied by improvement in certain measures of cognitive function in elderly patients with GHD.

show abstract

Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients

Cited by 36 publications

References 16 publications

MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?

MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?

Effect of Growth Hormone Replacement Therapy on Cognition after Traumatic Brain Injury

Effects of GH on cognitive function in elderly patients with adult-onset GH deficiency: a placebo-controlled 12-month study

Contact Info

Product

Resources

About