Somatotopy within the Internal Capsule Illustrated by Diffusion Tensor Tractography

Golay, Michel; Meuli, Reto; Croquelois, Alexandre

doi:10.1159/000232928

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“…9 Recent studies using diffusion tensor magnetic resonance imaging (DTI) and diffusion tensor tractography (DTT) have produced relatively unanimous results regarding the location of the corticospinal tract in human PLIC, and the locations of the hand and foot areas within the PLIC. [10][11][12] However, there are few studies on the somatotopic organization of the corticospinal tract in rats, specifically the organization of forelimb and hindlimb areas within the internal capsule. Thus, there is a very real possibility of incorrect targeting in rat capsular infarct models.…”

Section: Introductionmentioning

confidence: 99%

Capsular stroke modeling based on somatotopic mapping of motor fibers

Song

Jung

Lee

et al. 2016

J Cereb Blood Flow Metab

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Recently, several capsular stroke models have been reported with different targets of destruction. This study was performed to establish an accurate internal capsule (IC) target for capsular stroke modeling in rats. We injected adeno-associated virus serotype 5 (AAV)-CaMKII-EYFP into forelimb motor cortex and AAV-CaMKII-mCherry into hindlimb motor cortex (n = 9) to anterogradely trace the pyramidal fibers and map their somatotopic distribution in the IC. On the basis of the neural tracing results, we created photothrombotic infarct lesions in rat forelimb and hindlimb motor fiber (FMF and HMF) areas of the IC (n = 29) and assessed motor behavior using a forelimb-use asymmetry test, a foot-fault test, and a single-pellet reaching test. We found that the FMFs and HMFs were primarily distributed in the inferior portion of the posterior limb of the IC, with the FMFs located largely ventral to the HMFs but with an area of partial overlap. Photothrombotic lesions in the FMF area resulted in persistent motor deficits. In contrast, lesions in the HMF area did not result in persistent motor deficits. These results indicate that identification of the somatotopic distribution of pyramidal fibers is critical for accurate targeting in animal capsular stroke models: only infarcts in the FMF area resulted in long-lasting motor deficits.

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Section: Introductionmentioning

confidence: 99%