Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging

Brooks, Jonathan; Zambreanu, L.; Godinez, A.; Craig, A. D.; Tracey, Irene

doi:10.1016/j.neuroimage.2005.03.041

Cited by 314 publications

(219 citation statements)

References 54 publications

Supporting

Mentioning

189

Contrasting

Unclassified

Order By: Relevance

“…4,28,32 Currently there are no anatomically defined limits between the various cytoarchitectural divisions of the insula. Other proposed functions of the insula include modulation of language production and grammatical processing.…”

Section: Developmental Anatomy Of the Insulamentioning

confidence: 99%

Embryological development of the human insula and its implications for the spread and resection of insular gliomas

Kalani

Gwinn

et al. 2009

FOC

View full text Add to dashboard Cite

The human insular cortex, or the lobus insularis, is considered the developmentally most primitive lobe of the telencephalon. Covered by an overlying cortical lid, the insula has functions that are distinct from yet related to those of the adjacent temporal lobe and deep limbic structures. In the first part of this paper the authors outline the development of the human insula, including the cellular heterogeneity comprising the various parts of the insular lobe. Using the understanding gained from the development of the insula they then address implications of insular development for cortical development and connection as well as for tumorigenesis and tumor spread from the insula to other cortical structures, most notably the temporal lobe. An understanding of cortico-insular development and interconnection allows for both a better understanding of insular pathology and also facilitates planning of resection of cortico-insular gliomas to avoid damage to eloquent structures.

show abstract

Section: Developmental Anatomy Of the Insulamentioning

confidence: 99%

Embryological development of the human insula and its implications for the spread and resection of insular gliomas

Kalani

Gwinn

et al. 2009

FOC

View full text Add to dashboard Cite

show abstract

“…Extensive studies suggest that thinfiber networks mediating pain and temperature connect from the superficial laminae of the dorsal horn via somatotopically arranged projections through the spinothalamic tract (STT) to a specific ventromedial posterior thalamic nuclei (VMPo), terminating in the contra-lateral posterior insular cortex (Craig et al, 1994(Craig et al, , 1999Blomqvist and Craig, 2000;Craig, 2003;Craig and Zhang, 2006) (but see Willis et al, 2002). Consistent with these projections, functional imaging of innocuous cooling as well as painful stimuli have revealed a cortically maintained somatotopic organization of the posterior insula with upper body afferents activating regions anterior to those of the lower body (Brooks et al, 2005;Hua le et al, 2005;Henderson et al, 2007).…”

Section: Introductionmentioning

confidence: 95%

Somatotopic Organization of Gentle Touch Processing in the Posterior Insular Cortex

Björnsdotter¹,

Löken²,

Olausson³

et al. 2009

J. Neurosci.

237

151

View full text Add to dashboard Cite

A network of thin (C and A␦) afferents relays various signals related to the physiological condition of the body, including sensations of gentle touch, pain, and temperature changes. Such afferents project to the insular cortex, where a somatotopic organization of responses to noxious and cooling stimuli was recently observed. To explore the possibility of a corresponding body-map topography in relation to gentle touch mediated through C tactile (CT) fibers, we applied soft brush stimuli to the right forearm and thigh of a patient (GL) lacking A␤ afferents, and six healthy subjects during functional magnetic resonance imaging (fMRI). For improved fMRI analysis, we used a highly sensitive multivariate voxel clustering approach. A somatotopic organization of the left (contralateral) posterior insular cortex was consistently demonstrated in all subjects, including GL, with forearm projecting anterior to thigh stimulation. Also, despite denying any sense of touch in daily life, GL correctly localized 97% of the stimuli to the forearm or thigh in a forced-choice paradigm. The consistency in activation patterns across GL and the healthy subjects suggests that the identified organization reflects the central projection of CT fibers. Moreover, substantial similarities of the presently observed insular activation with that described for noxious and cooling stimuli solidify the hypothesized sensory-affective role of the CT system in the maintenance of physical well-being as part of a thin-afferent homeostatic network.

show abstract

“…Several functional imaging studies suggest that the posterior operculo-insular complex has a role in pain discrimination and localization (Hua et al, 2005;Baumgärtner et al, 2006). Other studies have identified a region in the anterior insula that becomes activated by noxious stimuli (Brooks et al, 2002(Brooks et al, , 2005Henderson et al, 2007). It is interesting to note that the clinical responses evoked by ES within the anterior insular part are usually ipsi-or bilateral to the original peripheral stimulus (Tarkka & Treede, 1993;Henderson et al, 2006;Afif et al, 2008b Fig.…”

Section: Painmentioning

confidence: 94%

Robotic Arm and Imaging in Neurosurgical Stereotactic Interventions: Oblique Insular Electrodes Implanted in Patients with Epilepsy

Afif¹

2012

Neuroimaging - Clinical Applications

View full text Add to dashboard Cite

Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging

Cited by 314 publications

References 54 publications

Embryological development of the human insula and its implications for the spread and resection of insular gliomas

Embryological development of the human insula and its implications for the spread and resection of insular gliomas

Somatotopic Organization of Gentle Touch Processing in the Posterior Insular Cortex

Robotic Arm and Imaging in Neurosurgical Stereotactic Interventions: Oblique Insular Electrodes Implanted in Patients with Epilepsy

Contact Info

Product

Resources

About