Somatotopic Location of Corticospinal Tracts in the Internal Capsule with MR Tractography

Lee, Dong Hoon; Kwon, Yong Hyun; Hwang, Yoon Tae; Kim, Joong Hwi; Park, Ji Won

doi:10.1159/000334097

Cited by 10 publications

(10 citation statements)

References 24 publications

(31 reference statements)

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“…Corticobulbar and corticospinal tract degeneration are phenotype‐defining features of ALS, yet these tracts are rarely examined separately and correlated with clinical disability. These tracts are relatively well separated in the internal capsule (IC) where corticobulbar tracts run in the genu of the IC and CSTs run in the posterior limb of the IC in a somatotopic arrangement, representing the upper extremity, trunk, lower extremity in an anteromedial to posterolateral anatomical organization . Spastic speech, dysphagia, positive jaw‐jerk and pseudobulbar affect are just some of the frequently observed symptoms in ALS that can be directly linked to corticobulbar tract dysfunction.…”

Section: Introductionmentioning

confidence: 99%

The segmental diffusivity profile of amyotrophic lateral sclerosis associated white matter degeneration

Schuster

Elamin

Hardiman

et al. 2016

Euro J of Neurology

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Section: Introductionmentioning

confidence: 99%

The segmental diffusivity profile of amyotrophic lateral sclerosis associated white matter degeneration

Schuster

Elamin

Hardiman

et al. 2016

Euro J of Neurology

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“…Particularly, the somatotopic location of CST in the CR is an important consideration for the patients with brain injury because the lesions of brain injury are commonly located on the CR. Recently, many studies have been done for elucidating the somatotopic location of CST using diffusion-tensor tractography (DTT), which derived from diffusion-tensor image (DTI), combined with other technical methods such as functional magnetic resonance imaging (fMRI) (Holodny et al, 2005a,b; Hagmann et al, 2006; Smits et al, 2007; Mukherjee et al, 2008; Mancini et al, 2009; Suzuki et al, 2009; Masri, 2011; Jang, 2011; Lee et al, 2012; Seo et al, 2012). …”

Section: Introductionmentioning

confidence: 99%

Diffusion-Tensor Magnetic Resonance Imaging for Hand and Foot Fibers Location at the Corona Radiata: Comparison with Two Lesion Studies

Lee

Hong

Han

2014

Front. Hum. Neurosci.

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The corticospinal tract is the motor pathway in the human brain, and corona radiata (CR) is an important location to diagnose stroke. We detected hand and foot motor fiber tracts in the CR to investigate accurate locations using diffusion-tensor imaging (DTI) and functional imaging. Ten right-handed normal volunteers participated in this study. We used a probabilistic tracking algorithm, a brain normalization method, and functional imaging results to set out region of interests. Moreover, our results were compared to previous results of lesion studies to confirm their accuracy and usefulness. The location measurements were performed in two index types; anteriority index on the basis of the anterior and posterior location of lateral ventricle and laterality index on the basis of the left and right location. The anteriority indices were 56.40/43.2 (hand/foot) at the upper CR and lower CR 40.72/30.90 at the lower CR. The measurements of anteriority and laterality of motor fibers were represented as anteriority index 0.40/0.31 and laterality index 0.60/0.47 (hand/foot). Our results showed that the hand and foot fibers were in good agreements with previous lesion studies. This study and approaches can be used as a standard for DTI combined with lesion location studies in patients who need rehabilitation or follow-up.

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“…Using the orientation convention used in the present paper (Fig. 2), the hand was described to be either lateral (Holodny et al, 2005; Ino et al, 2007) or anterior to the foot fascicle (Ino et al, 2007; Lee et al, 2012; Park et al, 2008). A study using direct white matter electrical stimulation in the PLIC area reported a face-anterior, arm-intermediate and leg-posterior somatotopic organization (Duerden et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Several diffusion tensor imaging (DTI)-based studies have observed differences in somatotopic organization. For instance, in the long axis of the corona radiata (CR) and the posterior limb of the internal capsule (PLIC), hand fascicles were either anterolateral to foot fascicles at the CR (Lee et al, 2014; Seo et al, 2012) and PLIC (Park et al, 2008) or anteromedial at the PLIC (Lee et al, 2012). Other studies found the hand fascicles to be anterolateral to the foot fascicles and partially overlapping relationships have been observed at lower levels (Holodny et al, 2005; Ino et al, 2007; Smits et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies used a conventional single-tensor DTI model (Holodny et al, 2005; Park et al, 2008; Smits et al, 2007), which cannot resolve the problem of crossing fibres (Akter et al, 2011). This problem has been addressed using probabilistic tractography (Lee et al, 2012, Lee et al, 2014; Seo et al, 2012). The necessary seed regions of interest (ROIs) required for the tracts dissection were identified manually either on the basis of anatomical landmarks (Hong et al, 2010; Kwon et al, 2011; Park et al, 2008; Seo et al, 2012) or through the application of functional magnetic resonance imaging (fMRI)-based methods.…”

Section: Introductionmentioning

confidence: 99%

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Somatotopic organization of corticospinal/corticobulbar motor tracts in controls and patients with tumours: A combined fMRI–DTI study

Hazzaa

Mancini

Thornton

et al. 2019

NeuroImage: Clinical

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Objectives To investigate the relative somatotopic organization of the motor corticospinal/corticobulbar foot, hand, lip and tongue fascicles by combining fMRI with DTI and to examine the influence of subjacent intrinsic tumours on these fascicles. Methods The study was approved by the local ethics committee. Seven male and three female volunteers (median age: 35 years) and one female and eight male patients with brain tumours (median age: 37 years) were scanned on a 1.5-T MRI scanner. fMRI data, analysed using SPM5, identified the motor task-driven fMRI grey matter activations of the hand, foot, lips and tongue as seed regions for probabilistic tractography. The relationship between the components of the CST was assessed and the distances between them were measured. A statistical comparison was performed comparing these distances in the group of healthy hemispheres with those of the group of non-affected hemispheres and healthy hemispheres. Results Hand fascicles were identified in all subjects (38/38, 100%), followed by foot (32/38, 84%), lip (31/38, 81%) and tongue fascicles (28/38, 74%). At superior levels, the hand fascicles were anterolateral to the foot fascicles in 77–93% of healthy hemispheres (HH), in 50–71% of non-affected patients' hemispheres (pH) and in 67–89% of affected PH. At inferior levels, the hand fascicles were either anteromedial in 46–45% of HH or anterior in 75% of non-affected PH and in 67–83% of affected PH. Tongue and lip fascicles overlapped in 25–45% of HH, in 10–20% of non-affected PH and in 15–25% of affected PH. No significant difference was found between the group of affected hemispheres and that of healthy and non-affected hemispheres. Conclusion The somatotopy of the hand fascicles in relation to the foot fascicles was anterolateral in patients and volunteers at superior levels but anteromedial in volunteers and mostly anterior in patients at inferior levels. The lip and tongue fascicles generally overlapped. Intracranial tumours displaced the motor fascicles without affecting their relative somatotopy.

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Somatotopic Location of Corticospinal Tracts in the Internal Capsule with MR Tractography

Cited by 10 publications

References 24 publications

The segmental diffusivity profile of amyotrophic lateral sclerosis associated white matter degeneration

The segmental diffusivity profile of amyotrophic lateral sclerosis associated white matter degeneration

Diffusion-Tensor Magnetic Resonance Imaging for Hand and Foot Fibers Location at the Corona Radiata: Comparison with Two Lesion Studies

Somatotopic organization of corticospinal/corticobulbar motor tracts in controls and patients with tumours: A combined fMRI–DTI study

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