Somatostatin receptor subtypes 2 and 5 mediate inhibition of egg yolk-induced gall bladder emptying in mice

Kaczmarek, Przemysław; Singh, Vandana; Cashen, Doreen E.; Lu, Yang; Berk, Scott C.; Pasternak, Alexander; Xiong, Yusheng; Shen, Dong‐Ming; Hutchins, Steven M.; Chapman, Kevin T.; Wiedenmann, Bertram; Schaeffer, James M.; Strowski, Mathias Z.

doi:10.1111/j.1365-2982.2009.01407.x

Cited by 8 publications

(6 citation statements)

References 37 publications

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“…SST is known to inhibit hepatic bile secretion and gallbladder emptying ( Ahrendt et al, 1991 ). Study has shown that SSTR2 and SSTR5 may play a primary role in regulating gall bladder emptying in mice ( Kaczmarek et al, 2010 ). The expression of SSTR5 was also found to be significantly increased in gallbladder cancer than in normal gallbladder tissue in human ( Guo et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Variants in motilin, somatostatin and their receptor genes and risk of biliary tract cancers and stones in Shanghai, China

Hsing

Koshiol

et al. 2014

Meta Gene

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Altered motility of the gallbladder can result in gallstone and cholecystitis, which are important risk factors for biliary tract cancer. Motilin (MLN) and somatostatin (SST) are known important modulators of gallbladder motility. To determine whether genetic variants in motilin, somatostatin, and their receptor genes are associated with the risk of biliary tract cancers and stones, nine tag-SNPs were determined in 439 biliary tract cancer cases (253 gallbladder, 133 extrahepatic bile duct and 53 ampulla of Vater cancer cases), 429 biliary stone cases, and 447 population controls in a population-based case–control study in Shanghai, China. We found that subjects with the MLNR rs9568169 AA genotype and SSTR5 rs169068 CC genotype were significantly associated with risk of extrahepatic bile duct cancer (OR = 0.49, 95% CI: 0.27–0.89; OR = 2.40, 95% CI: 1.13–5.13) compared to the major genotypes. MLN rs2281820 CT and rs3793079 AT genotypes had significantly increased risks of gallstones (OR = 1.52, 95% CI: 1.06–2.18; OR = 1.64, 95% CI: 1.20–2.25) compared to TT genotypes. Besides, haplotype analysis showed that MLN T-T-T haplotype (rs2281820–rs3793079–rs2281819) had a non-significantly elevated risk of gallstone (OR = 1.30, 95% CI: 0.91–1.86) compared with C-A-A haplotype. To the best of our knowledge, this is the first study to report an association between genetic polymorphisms in MLN, MLNR and their receptor genes and risk of biliary tract cancers and stones.

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Section: Discussionmentioning

confidence: 99%

Variants in motilin, somatostatin and their receptor genes and risk of biliary tract cancers and stones in Shanghai, China

Hsing

Koshiol

et al. 2014

Meta Gene

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“…Besides, the expression of five subtypes of SSTR showed no apparently correlating property with the age of patients, the histological types of tumor, invasion depth and liver metastasis. Agonists with high selectivity for SSTR2 or SSTR5 could suppress gallbladder emptying, whereas SSTR1-, SSTR3-and SSTR4-selective agonists failed to cause gallbladder contraction (Kaczmarek et al, 2010) and SST induced apoptosis concerning the expression of p53 and Bax protein (Songgang et al, 2009). Consider of less clinical cases in our research, further study on more cases of gallbladder cancer patients need to be carried on the mechanism of SSTR mediated gallbladder cancer and the mechanism of SSTR participates gallbladder cancer formation needs to carry out (Behr et al, 2002;Fiebiger et al, 2002;Chopra, 2004;Harada et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Somatostatin Receptors 3, 4 and 5 Play Important Roles in Gallbladder Cancer

Guo

Shi²,

Zhou³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…A large number of studies have sought to characterize the expression of SSTs in human pancreatic tissues, but cataloging the differences between them is beyond the scope of this review ( 6 , 12 , 27 , 28 ). Taken together, somatostatin effects in β-cells are predominantly mediated by SST2, SST5 and perhaps SST1, while the impact of SST3 is unclear.…”

Section: Somatostatin Receptor Distributionmentioning

confidence: 99%

Somatostatin receptors in congenital hyperinsulinism: Biology to bedside

et al. 2022

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Congenital hyperinsulinism (CHI), although a rare disease, is an important cause of severe hypoglycemia in early infancy and childhood, causing preventable morbidity and mortality. Prompt diagnosis and appropriate treatment is necessary to prevent hypoglycaemia mediated brain damage. At present, the medical treatment of CHI is limited to diazoxide as first line and synthetic somatostatin receptor ligands (SRLs) as second line options; therefore understanding somatostatin biology and treatment perspectives is important. Under healthy conditions, somatostatin secreted from pancreatic islet δ-cells reduces insulin release through somatostatin receptor induced cAMP-mediated downregulation and paracrine inhibition of β- cells. Several SRLs with extended duration of action are now commercially available and are being used off-label in CHI patients. Efficacy remains variable with the present generation of SRLs, with treatment effect often being compromised by loss of initial response and adverse effects such as bowel ischaemia and hepatobiliary dysfunction. In this review we have addressed the biology of the somatostatin system contexualised to CHI. We have discussed the clinical use, limitations, and complications of somatostatin agonists and new and emerging therapies for CHI.

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Somatostatin receptor subtypes 2 and 5 mediate inhibition of egg yolk-induced gall bladder emptying in mice

Abstract: Our study provides evidence for the role of SSTR2 and SSTR5 in regulating gall bladder emptying in mice.

Cited by 8 publications

References 37 publications

Variants in motilin, somatostatin and their receptor genes and risk of biliary tract cancers and stones in Shanghai, China

Variants in motilin, somatostatin and their receptor genes and risk of biliary tract cancers and stones in Shanghai, China

Somatostatin Receptors 3, 4 and 5 Play Important Roles in Gallbladder Cancer

Somatostatin receptors in congenital hyperinsulinism: Biology to bedside

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