“…(War et al, 2011, Hukovic et al, 1996. The appropriate density of membrane bound SSTRs contributes to the sensitivity and effectiveness of in vivo peptide-targeted therapy for somatotroph adenomas (Daly et al, 2006, Acunzo et al, 2008. Also, a longer relapseAbbreviations: EGF, Epidermal growth factor; ERK, Extracellular signal-regulated kinase; EST, 17b-estradiol; GPCRs, G protein-coupled receptors; HA, Hemagglutinin; MAPK, Mitogen-activated protein kinase; MTT, (3-(4, 5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide); PARP-1, Poly (ADP-ribose) polymerase-1; PBS, Phosphate buffered saline; PI3K, Phosphatidylinositol 3-kinase; PTP-1C, Protein tyrosine phosphatase-1C; SST, Somatostatin; SSTR, Somatostatin receptor; TUNEL, Terminal deoxynucleotidyl transferase dUTP nick end labeling.…”