Somatostatin neurons of the bed nucleus of stria terminalis enhance associative fear memory consolidation in mice

Bruzsik, Biborka; Biró, László Péter; Zelena, Dóra; Sipos, Eszter; Szebik, Huba; Sarosdi, Klara Rebeka; Horváth, Orsolya; Farkas, Imre; Csillag, Veronika; Finszter, Cintia Klaudia; Mikics, Éva; Tóth, Máté

doi:10.1101/2020.05.22.103481

Cited by 2 publications

(6 citation statements)

References 64 publications

(47 reference statements)

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“…-MeA (Dabrowska et al, 2016;Bruzsik et al, 2021) -CeA (Dabrowska et al, 2016;Bruzsik et al, 2021) -BLA (Dabrowska et al, 2016;Bruzsik et al, 2021) Thalamus:…”

Section: Inputunclassified

“…- -Dorsal striatum (Smith et al, 2016;Lu et al, 2021) -NAc (Dabrowska et al, 2016;Xiao et al, 2021) -SNc (Smith et al, 2016;Bruzsik et al, 2021) -…”

Section: Inputmentioning

confidence: 99%

“…-Caudate nucleus (Torrisi et al, 2015) -Putamen (Avery et al, 2014) -NAc (Torrisi et al, 2015) Behavioural function and dysfunction -Stress induced nociception (Tran et al, 2012) (Acute) pain related behaviors (Myers et al, 2014;Fang et al, 2023) -Anxiety related responses (freezing behaviour) (Kalin et al, 2005) -Sustained anxiety/threat anticipa tion/threat processing (Davis et al, 2010;Alvarez et al, 2011;Grupe et al, 2012;Somerville et al, 2013;Herrmann et al, 2016;Brinkmann et al, 2018;Camilo et al, 2022) (Continued) , 1998;Eiler et al, 2003) -Anxiety like behaviour during withdrawal (Huang et al, 2010) -Arousal (Ju et al, 1989) -Conditioned anxiety/ contextual fear/ sustained anxiety (Sullivan et al, 2004;Vantrease et al, 2022) -Sustained anxiety/threat anticipation/ threat processing (Fellinger et al, 2021) -Pavlovian fear and reward behaviour/learning (Bruzsik et al, 2021;Kaouane et al, 2021) -Regulation of food intake (Wang et al, 2019) -Alcohol-and drug-motivated behaviour (Silberman et al, 2013) -Threat anticipation/evaluation of threatening stimuli (Hoffman et al, 2007) -Behavioural inhibition (Fox et al, 2010) -Social/affiliative behaviour: aggression, mating behaviour, maternal care, social interaction (Jacobs et al, 2023) -Phasic threat processing (Gungor and Paré, 2016;Shackman and Fox, 2016;Klumpers et al, 2017;Brinkmann et al, 2018;…”

Section: Cerebral Cortexmentioning

confidence: 99%

“…As an example, in the PFC and CeA SOM positive neurons are involved in driving passive fear responses, whilst CRF neurons drive active fear responses (Fadok et al, 2017;Cummings and Clem, 2020). A recent study by Bruzsik and colleagues revealed that specific SOM cells within the BNST promote fear memory formation in mice (Bruzsik et al, 2021). Another study revealed that GABAergic SOM positive projection neurons from the BNST onto NAc interneurons control anxiety-like responses (Xiao et al, 2021).…”

Section: Somatostatinmentioning

confidence: 99%

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The neurophysiological basis of stress and anxiety - comparing neuronal diversity in the bed nucleus of the stria terminalis (BNST) across species

van de Poll,

Cras,

Ellender

2023

Front. Cell. Neurosci.

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The bed nucleus of the stria terminalis (BNST), as part of the extended amygdala, has become a region of increasing interest regarding its role in numerous human stress-related psychiatric diseases, including post-traumatic stress disorder and generalized anxiety disorder amongst others. The BNST is a sexually dimorphic and highly complex structure as already evident by its anatomy consisting of 11 to 18 distinct sub-nuclei in rodents. Located in the ventral forebrain, the BNST is anatomically and functionally connected to many other limbic structures, including the amygdala, hypothalamic nuclei, basal ganglia, and hippocampus. Given this extensive connectivity, the BNST is thought to play a central and critical role in the integration of information on hedonic-valence, mood, arousal states, processing emotional information, and in general shape motivated and stress/anxiety-related behavior. Regarding its role in regulating stress and anxiety behavior the anterolateral group of the BNST (BNSTALG) has been extensively studied and contains a wide variety of neurons that differ in their electrophysiological properties, morphology, spatial organization, neuropeptidergic content and input and output synaptic organization which shape their activity and function. In addition to this great diversity, further species-specific differences are evident on multiple levels. For example, classic studies performed in adult rat brain identified three distinct neuron types (Type I-III) based on their electrophysiological properties and ion channel expression. Whilst similar neurons have been identified in other animal species, such as mice and non-human primates such as macaques, cross-species comparisons have revealed intriguing differences such as their comparative prevalence in the BNSTALG as well as their electrophysiological and morphological properties, amongst other differences. Given this tremendous complexity on multiple levels, the comprehensive elucidation of the BNSTALG circuitry and its role in regulating stress/anxiety-related behavior is a major challenge. In the present Review we bring together and highlight the key differences in BNSTALG structure, functional connectivity, the electrophysiological and morphological properties, and neuropeptidergic profiles of BNSTALG neurons between species with the aim to facilitate future studies of this important nucleus in relation to human disease.

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“…-MeA (Dabrowska et al, 2016;Bruzsik et al, 2021) -CeA (Dabrowska et al, 2016;Bruzsik et al, 2021) -BLA (Dabrowska et al, 2016;Bruzsik et al, 2021) Thalamus:…”

Section: Inputunclassified

“…- -Dorsal striatum (Smith et al, 2016;Lu et al, 2021) -NAc (Dabrowska et al, 2016;Xiao et al, 2021) -SNc (Smith et al, 2016;Bruzsik et al, 2021) -…”

Section: Inputmentioning

confidence: 99%

Section: Cerebral Cortexmentioning

confidence: 99%

Section: Somatostatinmentioning

confidence: 99%

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The neurophysiological basis of stress and anxiety - comparing neuronal diversity in the bed nucleus of the stria terminalis (BNST) across species

van de Poll,

Cras,

Ellender

2023

Front. Cell. Neurosci.

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show abstract

“…Then, at pseudorandom intervals (60-90 s), a 30-s-long conditioned stimulus (CS: 80 dB pure tone at 7 kHz) was played and co-terminated with an unconditioned stimulus (foot shock: 0.7 mA, 1 s long, seven times in total), for a total of 11 min (Figure 5D). The following day, the experiment was repeated, except that the animals did not receive foot shocks at the end of the CSs (72). The chambers were cleaned with soap water and water after every trial.…”

Section: Conditioned Fear Testmentioning

confidence: 99%

Ovariectomy-induced hormone deprivation aggravates Aβ1-42 deposition in the basolateral amygdala and cholinergic fiber loss in the cortex but not cognitive behavioral symptoms in a triple transgenic mouse model of Alzheimer’s disease

et al. 2022

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Alzheimer’s disease is the most common type of dementia, being highly prevalent in elderly women. The advanced progression may be due to decreased hormone synthesis during post-menopause as estradiol and progesterone both have neuroprotective potentials. We aimed to confirm that female hormone depletion aggravates the progression of dementia in a triple transgenic mouse model of Alzheimer’s disease (3xTg-AD). As pathological hallmarks are known to appear in 6-month-old animals, we expected to see disease-like changes in the 4-month-old 3xTg-AD mice only after hormone depletion. Three-month-old female 3xTg-AD mice were compared with their age-matched controls. As a menopause model, ovaries were removed (OVX or Sham surgery). After 1-month recovery, the body composition of the animals was measured by an MRI scan. The cognitive and anxiety parameters were evaluated by different behavioral tests, modeling different aspects (Y-maze, Morris water maze, open-field, social discrimination, elevated plus maze, light–dark box, fox odor, operant conditioning, and conditioned fear test). At the end of the experiment, uterus was collected, amyloid-β accumulation, and the cholinergic system in the brain was examined by immunohistochemistry. The uterus weight decreased, and the body weight increased significantly in the OVX animals. The MRI data showed that the body weight change can be due to fat accumulation. Moreover, OVX increased anxiety in control, but decreased in 3xTg-AD animals, the later genotype being more anxious by default based on the anxiety z-score. In general, 3xTg-AD mice moved less. In relation to cognition, neither the 3xTg-AD genotype nor OVX surgery impaired learning and memory in general. Despite no progression of dementia-like behavior after OVX, at the histological level, OVX aggravated the amyloid-β plaque deposition in the basolateral amygdala and induced early cholinergic neuronal fiber loss in the somatosensory cortex of the transgenic animals. We confirmed that OVX induced menopausal symptoms. Removal of the sexual steroids aggravated the appearance of AD-related alterations in the brain without significantly affecting the behavior. Thus, the OVX in young, 3-month-old 3xTg-AD mice might be a suitable model for testing the effect of new treatment options on structural changes; however, to reveal any beneficial effect on behavior, a later time point might be needed.

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Somatostatin neurons of the bed nucleus of stria terminalis enhance associative fear memory consolidation in mice

Cited by 2 publications

References 64 publications

The neurophysiological basis of stress and anxiety - comparing neuronal diversity in the bed nucleus of the stria terminalis (BNST) across species

The neurophysiological basis of stress and anxiety - comparing neuronal diversity in the bed nucleus of the stria terminalis (BNST) across species

Ovariectomy-induced hormone deprivation aggravates Aβ1-42 deposition in the basolateral amygdala and cholinergic fiber loss in the cortex but not cognitive behavioral symptoms in a triple transgenic mouse model of Alzheimer’s disease

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