Somatostatin‐induced modulation of inflammation in experimental arthritis

Abstract

Objective. To study the antiinflammatory effect of different doses of intraarticular somatostatin in experimental arthritis in rabbits. Methods. Chronic arthritis was induced by a single injection of fibrin into the knee joint of rabbits previously sensitized to this antigen. The effects of sequential intraarticular injections of somatostatin into the rabbit knee, at doses of 500, 750, and 1,000 μg, were monitored by measuringknee joint circumferences and hematologic parameters. The measurements were compared with those obtained following use of triamcinolone acetonide and placebo. At the end of the experiments, the knee joints were examined histologically. Results. Somatostatin treatment induced a statistically significant and dose‐related reduction of knee joint swelling. This effect was shorter than that produced by triamcinolone acetonide; however, the antiinflammatory activity elicited by successive doses of triamcinolone acetonide declined both in extent and duration, while the effects of somatostatin remained unchanged at each successive treatment. Histopatho‐logic observations showed that both somatostatin and triamcinolone acetonide reduced the inflammatory signs in the joint structures, although triamcinolone acetonide appeared to be more effective. Conclusion. These findings suggest that somatostatin exerts an antiinflammatory effect in this model of experimental arthritis and may represent a valid and safer alternative to corticosteroids for intraarticular therapy of arthritis.

Somatostatin in inflammatory bowel disease

“…SMS reduces in ammation in experimental arthritis and ileal obstruction. 86,87 Similar bene cial effects on intestinal and colonic in ammation emerge from clinical observations in Crohn's disease and goldinduced enteritis. 88,89 SMS is able to reduce SP mediated in ammation induced by intestinal infection with Trichinell a spir alis 90 and SP enhanced neutrophil chemotaxis.…”

The role of cortistatin in the human immune system

“…SRIF decreases the extravasation of plasma and leukocytes and may reduce synovial swelling through this mechanism (Karalis et al, 1994). Reduction of joint swelling by intra-articular injection of SRIF is also observed in a rabbit model of chronic arthritis (Matucci-Cerinic et al, 1995). In addition, histological studies in this model have revealed reduction of lymphocyte infiltration in the synovium and reduced vasculitis in SRIF-treated animals.…”

Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune‐mediated arthritis

“…Local application of SRIF-14 into the inflamed knee joint in rabbits was shown to prevent joint swelling and edema (34)(35)(36). SRIF and its analogs also inhibit the production and release of proinflammatory mediators, such as TNF␣, IFN␥, and interleukin-6 in a number of inflammatory disorders (3,4,37,38).…”