Somatostatin administration modifies food intake, body weight, and gut motility in rat

Somatostatin, neuronal vulnerability and behavioral emotionality

“…SST is involved in feeding behaviors, 52,53 so we assessed the appetitive drive in the NSF paradigm by measuring the amount of food consumed in the home cage after NSF testing. In the first cohort, we observed a small but significant reduction in food consumption in Sst KO mice under baseline non-stressed conditions (Figure S3).…”

The effect of acute hyperglycaemia on appetite and food intake in Type 1 diabetes mellitus

“…An alternative means of preventing an increase in insulin levels in response to hyperglycaemia would have been to suppress insulin secretion by infusion of somatostatin or its analogue, octreotide. Such an approach would, however, be associated with substantial limitations, as somatostatin also affects gastrointestinal motility, inhibits the secretion of numerous hormones as well as insulin, and affects appetite in its own right [21].…”

The influence of selected pathological states on the somatostatin-like immunoreactive (SOM-LI) endocrine cells in the mucosal layer of the porcine descending colon

“…In spite of well known functions of SOM within whole GI tract such as the regulation of gut secretion, motility, blood flow and food intake (Li et al 1996, Scalera & Tarozzi 1998, for review, Low 2004) and described previous roles of SOM in the large intestine where it stimulates ion transport and inhibits chloride secretion (for review, see Low 2004), the number of SOM -positive endocrine cells in control animals were not large, what is in accordance with previous observations in other species, including human, where such endocrine cells in the colon were not numerous (Watanabe et al 1992) or they were no observed at all (Ku et al 2006, Aj Haj Ali et al 2007. Moreover, in this study changes in SOM-like immunoreactivity of the endocrine cells were observed under all pathological factors studied, what strongly suggests the role of SOM in adaptative processes within descending colon.…”

“…SOM also reduces gut secretion and exerts the inhibitory effects on many gut hormones including gastrin, cholecystokinin, vasoactive intestinal polypeptide (for review, Low 2004). Moreover SOM decreases the food intake, reduces the blood flow in the gut and affects the GI tract motility (Li et al 1996, Scalera & Tarozzi 1998 It is also an important anti-inflammatory and anti-nociceptive agent, which down-regulates lymphocyte proliferation, reduces immunoglobulin production and inhibits the release of proinflammatory cytokines (for review, see Ten Bokum et al 2000).…”