Somatosensory evoked potentials following stimulation of the trigeminal nerve in man

Stöhr, Manfred; Petruch, F

doi:10.1007/bf00313949

Cited by 98 publications

(26 citation statements)

References 8 publications

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“…This could explain no association between patient-reported symptoms and tSSEP results. Initial studies of the trigeminal nerve SSEP have proven to be an objective, non-invasive measurement of facial proprioception (19,20), and our study confirms these observations with an excellent neurophysiological-MRI association. Further studies investigating the clinical involvement of facial proprioception and tSSEP are warranted.…”

Section: Discussionsupporting

confidence: 85%

Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome

Skorić¹,

Adamec²,

Crnošija³

et al. 2016

Croat Med J

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AimTo test the hypothesis that tSSEP findings reflect clinical and MRI MS lesions, the aim of this study was to investigate tSSEP changes in patients with clinically isolated syndrome (CIS) in relation to clinical and brainstem MRI findings. The second aim was to investigate whether the interpretation of the tSSEP results in the form of the tSSEP score enables better evaluation of the afferent trigeminal pathway involvement than analyzing each tSSEP parameter separately.Methods115 consecutive CIS patients were enrolled from August 1, 2014 until March 1, 2016. Facial sensory symptoms and brainstem MRI (1.5 T) lesions were analyzed. tSSEP testing was performed for each patient from the raw tSSEP data. The tSSEP score was calculated separately for the left and right side (according to the cut-off values for absent response and prolonged latency of the main component, P1 (0 = normal response, 1 = prolonged latency, 3 = absent response) and the two values were summed.ResultsThere was no difference in the absolute values of the tSSEP variables regarding the presence of clinical symptoms. No association was found between tSSEP abnormalities and clinical symptoms (P = 0.544). Brainstem lesions (midbrain and pons) were associated with the absent tSSEP responses (P = 0.002 and P = 0.005, respectively). tSSEP score was significantly higher in patients with brainstem lesions (P = 0.01), especially midbrain (P = 0.004) and pontine (P = 0.008) lesions. Binary logistic regression showed that tSSEP score had a significant effect on the likelihood that patients have midbrain MR lesions, χ2(1) = 6.804, P = 0.009; and the model correctly classified 87% of cases.ConclusionsThe consistent finding of this study was the association between tSSEP and midbrain lesions on MRI, indicating that tSSEP evaluates proprioception of the face. This study establishes the value of tSSEP in assessing brainstem function in early multiple sclerosis.

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Section: Discussionsupporting

confidence: 85%

Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome

Skorić¹,

Adamec²,

Crnošija³

et al. 2016

Croat Med J

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“…16 17 The cause of disagreement may lie in the different methods of investigation, the first group of authors basing their opinion on testing of trigeminal reflexes and the second on cortical potentials evoked by stimulation in the trigeminal territory (TEPs). Both methods are open to criticism, since reflexes provide an indirect evaluation of trigeminal afferents through a motor response and the scalp potentials discussed here are bound to be contaminated by myogenic artifacts to such an extent that the cortical signal may be completely obscured.…”

Section: Electrophysiological Findings In Trigeminal Neuralgiamentioning

confidence: 99%

Intracranial stimulation of the trigeminal nerve in man. III. Sensory potentials.

Cruccu

Inghilleri

Manfredi

et al. 1987

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY Percutaneous electrical stimulation of the trigeminal root was performed in 18 subjects undergoing surgery for idiopathic trigeminal neuralgia or implantation of electrodes into Meckel's cave for recording of limbic epileptic activity. All subjects had normal trigeminal reflexes and evoked potentials. Sensory action potentials were recorded antidromically from the supraorbital (VI), infraorbital (V2) and mental (V3) nerves. In the awake subject, sensory potentials were usually followed by myogenic artifacts due to direct activation of masticatory muscles or reflex activation of facial muscles. In the anaesthetised and curarised subject, sensory potentials from the three nerves showed 1 4-2-2 ms onset latency, 1-9-2-7 ms peak latency and 17-29 pV amplitude. Sensory conduction velocity was computed at the onset latency (maximum CV) and 'at the peak latency (peak CV). On average, maximum and peak CV were 52 and 39 m/s for VI, 54 and 42 m/s for V2 and 54 and 44 m/s for V3. There was no apparent difference in CV between subjects with trigeminal neuralgia and those with epilepsy. A significant inverse correlation was found between CV and age, the overall maximum CV declining from 59 m/s (16 years) to 49 m/s (73 years). This range of CV is compatible both with histometric data and previous electrophysiological findings on trigeminal nerve conduction. Intraoperative intracranial stimulation is also proposed as a method of monitoring trigeminal function under general anaesthesia.The cutaneous branches of the trigeminal nerve remain in the depth of craniofacial structures for most of their course, and emerge on the surface of the face in the proximity of their target skin territory, dividing into thin, short, terminal fascicles. This leaves little room for stimulation and recording of nerve fibres in intact man, hence the absence of normative data on trigeminal nerve conduction.The available electroneurographic data have been achieved by intraoperative recordings, either by recording from' 2 or by stimulation of34 the ganglion and root, in subjects undergoing surgery for trigeminal neuralgia. This paper describes the sensory action potentials (SAPs) evoked in the supraorbital, infraorbital and mental nerves, by direct electrical stimulation of the trigeminal root, and the sensory conduction velocity

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“…TSEP has been mainly investigated by electroencephalography (EEG) (Stohr and Petruch, 1979), but magnetoencephalography (MEG) has also come into use for the trigeminal somatosensory-evoked field (TSEF), a MEG counterpart for TSEP (Karhu et al, 1991). MEG non-invasively localizes specific brain functions with millisecond-order temporal resolution and subcentimeter-order spatial resolution.…”

Section: Introductionmentioning

confidence: 99%

Effect of Local Anesthesia on Trigeminal Somatosensory-evoked Magnetic Fields

Otsuka

Dan²,

Dan³

et al. 2012

J Dent Res

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For objective neurophysiological evaluation of the function of the trigeminal system, magnetoencephalography- based TSEF (trigeminal somatosensory-evoked field) assessment would be valuable in providing spatial and temporal profiles of cortical responses. However, this necessitates knowledge of how TSEF varies with trigeminal nerve dysfunctions. We introduced a conduction block of the trigeminal nerve using local anesthesia (lidocaine) to temporally mimic nerve dysfunctions, and monitored TSEF changes. Following an electrical stimulation of the lower lip, a magnetic response with peak latency of approximately 20 ms was identified in all participants. Dipole for the peak was estimated on the post-central gyrus in the participant's own magnetic resonance image. After normalization to Montreal Neurological Institute (MNI) space and inter-participant data integration, the summary equivalent current dipole localization among participants remained in the post-central gyrus, suggesting validity of the use of MNI space. Partial anesthesia of the lower lip led to a loss of the waveform characteristics of TSEF for electrical stimulation to the trigeminal nerve. We verified that the 20-ms latency cortical response of TSEF components localized at the primary sensory cortex can serve as a robust neurofunctional marker of experimental trigeminal nerve dysfunction.

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Somatosensory evoked potentials following stimulation of the trigeminal nerve in man

Cited by 98 publications

References 8 publications

Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome

Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome

Intracranial stimulation of the trigeminal nerve in man. III. Sensory potentials.

Effect of Local Anesthesia on Trigeminal Somatosensory-evoked Magnetic Fields

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