Somatosensory evoked magnetic fields of periodontal mechanoreceptors

Hihara, Hiroki; Kanetaka, Hiroyasu; Kanno, Akira; Shimada, Eriya; Koeda, Satoko; Kawashima, Ryuta; Nakasato, Nobukazu; Sasaki, Keiichi

doi:10.1016/j.heliyon.2020.e03244

Cited by 8 publications

(5 citation statements)

References 51 publications

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“…The restored trigeminal proprioceptive pathway together with its specialized sensory discriminative features could further be corroborated in preclinical animal models using electroencephalographic, magnetoencephalographic 63 and fMRI approaches 64…”

Section: Discussionmentioning

confidence: 95%

Engineering Proprioceptive Implants via Surgical and Regenerative Approaches: Preliminary Interpretations

Das

Sarma²,

Bellare

2022

Preprint

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The periodontal ligaments are a group of specialized connective tissue fibres with vascular and neural elements that essentially attach a tooth to the alveolar bone. Endosseous dental implant replacing a lost tooth, gets ankylosed to the alveolar bone without intervening periodontal fibres (osseointegration). Hence, proprioception, one of the most important function of periodontal ligament is not elicited by commercial dental implants currently in use. To salvage the flaw, in our proof-of-principle trial in rabbits, biodegradable nanofibres were coiled around the additive manufactured (AM) customized titanium implants. Further, human dental pulp stem cells (DPSCs), adult mesenchymal stem cells of neuroectodermal origin, were seeded on the nanofibrous coated, orthotopically placed 3D-printed titanium implants and were induced to differentiate into neural cell lineages. The invivo anchoring mechanism of these biodegradable neuro-supportive scaffold coated implants could probably be proprioceptive osseointegration instead of defaults events leading to normal osseointegration and could exhibit features similar to periodontium, having possible anastomosis between the severed nerve terminals present in the wall of the extraction socket relaying to/from brain and newly differentiated neural cells present in the regenerated neo-tissue complex, gradually replacing the biodegradable scaffold and may eventually results in the development of proprioceptive osseointegrated root-form endosseous dental implants in near future.

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Section: Discussionmentioning

confidence: 95%

Engineering Proprioceptive Implants via Surgical and Regenerative Approaches: Preliminary Interpretations

Das

Sarma²,

Bellare

2022

Preprint

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“…Against our hypothesis, we did not find a significant correlation between MP and EC of the S1, even though its activation has been consistently found during a chewing task (Lin, 2018). Both animal and human research revealed that during mastication, S1 activity was associated with the processing of mechanosensation, the major source of sensory feedback from the peripheral site (Hihara et al, 2020; Kaneko et al, 2017). Therefore, the S1 may play an essential role in maintaining normal mastication.…”

Section: Discussionmentioning

confidence: 99%

Lower masticatory function relates to cognitive health and intrinsic brain network in older adults

2023

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ObjectivesMastication is associated with brain activation at the primary somatosensory cortex (S1) and the primary motor cortex (M1). Masticatory functions differ between patients with cognitive impairment (CI) and cognitively healthy older adults (non‐CI). The association between cognitive health, brain network of functional connectivity, and mastication has remained unknown. The study investigated the association between masticatory performance (MP) and the topological feature of the functional network at the M1 and S1 in the CI and non‐CI groups.Subjects and MethodsForty‐nine non‐CI and 15 CI subjects received resting‐state (rs) fMRI and assessment of MP. The topological feature of the M1 and S1 was quantified by eigenvector centrality (EC), an index that reflects a brain region as a functional “hub” of brain network.ResultsIn the non‐CI group, MP was significantly correlated with EC of the left M1 and the right M1. The correlation was not statistically significant in the CI group. Cognitive status (CI or non‐CI) and EC of the left M1 and the right M1, respectively, were statistically significant predictors to individual MP.ConclusionCognitive status and the topological feature of the M1 in the intrinsic functional network may contribute to the individual difference in masticatory function.

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“…In mice, fibers reach the VPM to innervate as 'barreloids' the thalamic nucleus (Erzurumlu et al, 2010) from r3 projections, while the spinal fibers enter as the contralateral medial lemniscus (SpV, gracile, and cuneate) to innervate the VPL (Iwasato and Erzurumlu, 2018). Interesting bilateral information is described in gums and teeth that show faster ipsilateral projections in humans and monkeys (Andrew et al, 2020;Hihara et al, 2020). We have a somatosensory, topological innervation (Figures 1A, 5A) to project to the mammalian cortex with a primary and secondary innervation giving rise to the SOC from r4/5.…”

Section: The Thalamus Receives the Topological Somatosensory Inputsmentioning

confidence: 99%

Neurosensory development of the four brainstem-projecting sensory systems and their integration in the telencephalon

Fritzsch

Elliott

Yamoah

2022

Front. Neural Circuits

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Somatosensory, taste, vestibular, and auditory information is first processed in the brainstem. From the brainstem, the respective information is relayed to specific regions within the cortex, where these inputs are further processed and integrated with other sensory systems to provide a comprehensive sensory experience. We provide the organization, genetics, and various neuronal connections of four sensory systems: trigeminal, taste, vestibular, and auditory systems. The development of trigeminal fibers is comparable to many sensory systems, for they project mostly contralaterally from the brainstem or spinal cord to the telencephalon. Taste bud information is primarily projected ipsilaterally through the thalamus to reach the insula. The vestibular fibers develop bilateral connections that eventually reach multiple areas of the cortex to provide a complex map. The auditory fibers project in a tonotopic contour to the auditory cortex. The spatial and tonotopic organization of trigeminal and auditory neuron projections are distinct from the taste and vestibular systems. The individual sensory projections within the cortex provide multi-sensory integration in the telencephalon that depends on context-dependent tertiary connections to integrate other cortical sensory systems across the four modalities.

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Somatosensory evoked magnetic fields of periodontal mechanoreceptors

Cited by 8 publications

References 51 publications

Engineering Proprioceptive Implants via Surgical and Regenerative Approaches: Preliminary Interpretations

Engineering Proprioceptive Implants via Surgical and Regenerative Approaches: Preliminary Interpretations

Lower masticatory function relates to cognitive health and intrinsic brain network in older adults

Neurosensory development of the four brainstem-projecting sensory systems and their integration in the telencephalon

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