Somatosensory-Evoked and Dermatomal-Evoked Potentials Are Not Clinically Useful in the Prognostication of Acute Spinal Cord Injury

Katz, Richard T.; Toleikis, Richard J.; Knuth, Albert E.

doi:10.1097/00007632-199107000-00007

Cited by 21 publications

(5 citation statements)

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“…SSEPs are used for clinical diagnosis in patients with neurologic disease, and many studies have been performed to determine the value of SSEPs in the prediction of walking recovery in SCI patients (Young and Dexter, 1979; Kaplan and Rosen, 1981; Young, 1985; Foo, 1986; Ziganow, 1986; Katz et al, 1991; Aalfs et al, 1993; Jacobs et al, 1995; Curt and Dietz, 1997). …”

Section: Instrumental Examinationmentioning

confidence: 99%

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Who is going to walk? A review of the factors influencing walking recovery after spinal cord injury

Scivoletto

Tamburella

Laurenza

et al. 2014

Front. Hum. Neurosci.

134

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The recovery of walking function is considered of extreme relevance both by patients and physicians. Consequently, in the recent years, recovery of locomotion become a major objective of new pharmacological and rehabilitative interventions. In the last decade, several pharmacological treatment and rehabilitative approaches have been initiated to enhance locomotion capacity of SCI patients. Basic science advances in regeneration of the central nervous system hold promise of further neurological and functional recovery to be studied in clinical trials. Therefore, a precise knowledge of the natural course of walking recovery after SCI and of the factors affecting the prognosis for recovery has become mandatory. In the present work we reviewed the prognostic factors for walking recovery, with particular attention paid to the clinical ones (neurological examination at admission, age, etiology gender, time course of recovery). The prognostic value of some instrumental examinations has also been reviewed. Based on these factors we suggest that a reliable prognosis for walking recovery is possible. Instrumental examinations, in particular evoked potentials could be useful to improve the prognosis.

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Section: Instrumental Examinationmentioning

confidence: 99%

“…However, SSEPs do not seem to offer additional prognostic accuracy if compared to clinical examination according to the ISNCSCI for both complete and incomplete patients (Young and Dexter, 1979; Kaplan and Rosen, 1981; Perot and Vera, 1982; Chabot et al, 1985; Katz et al, 1991; Aalfs et al, 1993; Curt and Dietz, 1997). …”

Section: Instrumental Examinationmentioning

confidence: 99%

Who is going to walk? A review of the factors influencing walking recovery after spinal cord injury

Scivoletto

Tamburella

Laurenza

et al. 2014

Front. Hum. Neurosci.

134

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“…Unfortunately, notwithstanding the remarkable development in therapeutic studies with SCI, our ability to examine the neurologic status of SCI patients has been limited. Some reports using electrophysiological techniques, SSEP or MEP mapping, to investigate corticospinal neural integrity after SCI have been published 4,24) ; however, the use of these to predict neurological outcomes remains under debate and the standard neurological examination remains as the first choice for assessing status and probable outcome following SCI 13,14) . The current study was performed to verify whether the functional cortical or subcortical changes can occur in patients with SCI after BMC transplantation and GM-CSF treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Recent experiments using somatosensoryevoked potential (SSEP) or motor evoked potential (MEP) mapping revealed the recovery of corticospinal neural integrity after SCI 4,24) . However, the use of these electrophysiological techniques in predicting neurological outcomes is still under debate and the standard neurological examination has remained as the first choice for assessing status and probable outcome following SCI 13,14) . To visualize the corticospinal neuronal integrities in SCI patients, functional brain mapping studies with functional magnetic resolution images (fMRI) and positron emission tomography (PET) have been widely investigated.…”

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confidence: 99%

Outcome Evaluation with Signal Activation of Functional MRI in Spinal Cord Injury

Jung

Yoon

et al. 2011

J Korean Neurosurg Soc

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“…For example, cortical SEPs have been studied in the early hours to first day after SCI with the goal to estimate spinal damage and predict subsequent recovery [56,57]. Alterations of the configuration of cortical SEPs have been reported, which reflect either an abnormal dorsal column function [58] or a spinothalamic tract contribution [59,60].…”

Section: Human Studies After Acute Scimentioning

confidence: 99%

Neural Plasticity After Spinal Cord Injury

Ding

Kastin²,

Pan³

2005

CPD

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Spinal cord injury (SCI) has devastating physical and socioeconomical impact. However, some degree of functional recovery is frequently observed in patients after SCI. There is considerable evidence that functional plasticity occurs in cerebral cortical maps of the body, which may account for functional recovery after injury. Additionally, these plasticity changes also occur at multiple levels including the brainstem, spinal cord, and peripheral nervous system. Although the interaction of plasticity changes at each level has been less well studied, it is likely that changes in subcortical levels contribute to cortical reorganization. Since the permeability of the blood-brain barrier (BBB) is changed, SCI-induced factors, such as cytokines and growth factors, can be involved in the plasticity events, thus affecting the final functional recovery after SCI. The mechanism of plasticity probably differs depending on the time frame. The reorganization that is rapidly induced by acute injury is likely based on unmasking of latent synapses resulting from modulation of neurotransmitters, while the long-term changes after chronic injury involve changes of synaptic efficacy modulated by long-term potentiation and axonal regeneration and sprouting. The functional significance of neural plasticity after SCI remains unclear. It indicates that in some situations plasticity changes can result in functional improvement, while in other situations they may have harmful consequences. Thus, further understanding of the mechanisms of plasticity could lead to better ways of promoting useful reorganization and preventing undesirable consequences.

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Somatosensory-Evoked and Dermatomal-Evoked Potentials Are Not Clinically Useful in the Prognostication of Acute Spinal Cord Injury

Cited by 21 publications

References 0 publications

Who is going to walk? A review of the factors influencing walking recovery after spinal cord injury

Who is going to walk? A review of the factors influencing walking recovery after spinal cord injury

Outcome Evaluation with Signal Activation of Functional MRI in Spinal Cord Injury

Neural Plasticity After Spinal Cord Injury

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