Somatosensory Event-Related Potentials and Selective Attention Impairment in Young Chronic Schizophrenics

Böning, Jobst; Drechsler, F.; Neuhauser, B.

doi:10.1159/000118568

Cited by 10 publications

(5 citation statements)

References 15 publications

(17 reference statements)

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“…The stimulus barrier was considered to be exceptionally weak in schizophrenics [28]. Remitted schizophrenics did not show any differences in latencies or amplitudes in an event-related study on SEPs [54], although attention-related reduced areas and prolonged latencies of the cognitive component N1 were observed.…”

Section: Discussionmentioning

confidence: 94%

High-Frequency Somatosensory Thalamocortical Oscillations and Psychopathology in Schizophrenia

Norra¹,

Waberski

Kawohl

et al. 2004

Neuropsychobiology

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Human cortical somatosensory evoked potentials (SEPs), which are presumably generated in afferent thalamocortical and early cortical fibers, reveal a burst of superimposed early (N20) high-frequency oscillations (HFOs), around 600 Hz. There is increasing evidence of an imbalance of thalamocortical systems in schizophrenic patients. In order to assess correlations between somatosensory evoked oscillations and symptoms of schizophrenia, we investigated median nerve SEPs in 20 inpatients and their age-matched and gender-matched healthy controls using a multichannel EEG. Dipole source analysis and wavelet transformation were performed before and after application of a 450-Hz high-pass filter. In schizophrenics, the maximum HFOs occurred with a significantly prolonged latency. There was also a higher amplitude (energy) in the low-frequency range of the N20 component compared with the controls. Importantly, amplitudes (energy) of HFOs were inversely correlated with symptoms of formal thought disorder and delusions. Alterations of the thalamocortical somatosensory signal processing in schizophrenia with absence of an early HFO – assumed to be of inhibitory nature – could indicate a dysfunctional thalamic inhibition with increased amplitudes of N20, paralleled by enhanced positive schizophrenic symptoms.

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Section: Discussionmentioning

confidence: 94%

High-Frequency Somatosensory Thalamocortical Oscillations and Psychopathology in Schizophrenia

Norra¹,

Waberski

Kawohl

et al. 2004

Neuropsychobiology

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“…These categories represent the primary means by which P300 was elicited, with auditory and visual oddball tasks most often employed. Selective attention paradigms (tasks that require target detection with multiple stimuli presented rapidly) were considerably more difficult and demanding than oddball tasks, with the ''other'' category including bimodal stimuli (Alain, Hargrave, & Woods, 1998;Grillon, Ameli, Courchesne, & Braff, 1991;Rockstroh, Mu¨ller, Wagner, Cohen, & Elbert, 1994;Shelley, Grochowski, Lieberman, & Javitt, 1996), somatosensory stimuli (Bo¨ning, Drechsler, & Neuhauser, 1989;Louza˜& Maurer, 1989), word recognition (Koyama et al, 1994), syllable discrimination , and other nonoddball P300 tasks (Condray, Steinhauer, Cohen, van Kammen, & Kasparek, 1999;Hiramatsu et al, 1984;Strandburg et al, 1994Strandburg et al, , 1997. As indicated in Table 2, the auditory oddball paradigm was employed most often and produced the overall largest d and smallest CI for both P300 amplitude and latency measures.…”

Section: Overview Of P300 Schizophrenia Studiesmentioning

confidence: 99%

Meta‐analysis of P300 and schizophrenia: Patients, paradigms, and practical implications

2003

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The goal of the present meta-analysis was to identify factors that contribute to P300 event-related brain potential (ERP) differences in patients with schizophrenia compared to unaffected controls in an attempt to characterize the clinically relevant dimensions underlying P300 deficits in patients with schizophrenia. P300 effect size (d) was smaller in amplitude and longer in latency in schizophrenic patients compared to normal controls, with the strongest effects obtained from the auditory oddball. Paranoid subtype demonstrated larger P300 amplitude effect sizes than other disease subtypes, and P300 latency effect size decreased with disease duration. Psychopathology severity and antipsychotic medications were unrelated to P300 amplitude effect size. Gender proportion, educational level, and stimulus and task variables also affected P300 amplitude and latency effect sizes. The findings are used to formulate a theoretical account of the empirical data and provide suggestions for maximizing the utility of the P300 component in the assessment of schizophrenia.

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“…Cognitive processes associated with somatosensory perception have also been examined (see review in (Chang and Lenzenweger 2004)). For example, it was found that somatosensory stimulation in a group of individuals with schizophrenia was associated with decreased activity in brain regions participating in an attentional network (Boning et al 1989). …”

Section: Introductionmentioning

confidence: 99%

Somatosensory System Deficits in Schizophrenia Revealed by MEG during a Median-Nerve Oddball Task

et al. 2009

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Although impairments related to somatosensory perception are common in schizophrenia, they have rarely been examined in functional imaging studies. In the present study, magnetoencephalography (MEG) was used to identify neural networks that support attention to somatosensory stimuli in healthy adults and abnormalities in these networks in patient with schizophrenia. A median-nerve oddball task was used to probe attention to somatosensory stimuli, and an advanced, high-resolution MEG source-imaging method was applied to assess activity throughout the brain. In nineteen healthy subjects, attention-related activation was seen in a sensorimotor network involving primary somatosensory (S1), secondary somatosensory (S2), primary motor (M1), pre-motor (PMA), and paracentral lobule (PCL) areas. A frontal–parietal–temporal “attention network”, containing dorsal- and ventral–lateral prefrontal cortex (DLPFC and VLPFC), orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), superior parietal lobule (SPL), inferior parietal lobule (IPL)/supramarginal gyrus (SMG), and temporal lobe areas, was also activated. Seventeen individuals with schizophrenia showed early attention-related hyperactivations in S1 and M1 but hypo-activation in S1, S2, M1, and PMA at later latency in the sensorimotor network. Within this attention network, hypoactivation was found in SPL, DLPFC, orbitofrontal cortex, and the dorsal aspect of ACC. Hyperactivation was seen in SMG/IPL, frontal pole, and the ventral aspect of ACC in patients. These findings link attention-related somatosensory deficits to dysfunction in both sensorimotor and frontal–parietal–temporal networks in schizophrenia.

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Somatosensory Event-Related Potentials and Selective Attention Impairment in Young Chronic Schizophrenics

Cited by 10 publications

References 15 publications

High-Frequency Somatosensory Thalamocortical Oscillations and Psychopathology in Schizophrenia

High-Frequency Somatosensory Thalamocortical Oscillations and Psychopathology in Schizophrenia

Meta‐analysis of P300 and schizophrenia: Patients, paradigms, and practical implications

Somatosensory System Deficits in Schizophrenia Revealed by MEG during a Median-Nerve Oddball Task

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