Somatosensory and visual evoked potentials in hyperthyroidism

Takahashi, Kentaro; Fujitani, Y

doi:10.1016/0013-4694(70)90097-0

Cited by 19 publications

(5 citation statements)

References 15 publications

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“…Because we did not study untreated older children with CH, we do not know if this normalization would continue in the absence of therapy. One early study (30) found normal P100 latency in a group of hypothyroid adults and reported decreased peak amplitudes like those that we found in CH infants.…”

Section: Discussionsupporting

confidence: 83%

Evoked Potentials Show Early and Delayed Abnormalities in Children with Congenital Hypothyroidism*

Cavallo

1989

Neuropediatrics

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To evaluate the effect of congenital hypothyroidism (CH) on nervous system development, we performed evoked potential studies on 7 CH infants at 3-8 weeks of age before treatment and at four months or more after treatment began. All infants were screened using filter paper determination of T4 and TSH, confirmed by serum specimen determinations. These infants had serum TSH concentrations greater than 100 microU/ml (normal less than 7), and the serum T4 range was 4.1-8.5 micrograms/dl. All had thyroid tissue on 99Tc scan; five had ectopic thyroid tissue, and two had a thyroid gland in the normal location. Four older CH children were tested after 3-6 years of treatment. Brainstem auditory evoked potentials (BAEP) were abnormal in three of the 7 infants and showed bilateral conduction delays in caudal brainstem regions. The BAEP became normal after 6 months of thyroxine treatment. Visual evoked potentials (VEP) were abnormally delayed and had an immature pattern in the four patients tested at four weeks of age. At age 8 weeks, even in untreated patients, the VEP was normal and remained so. Somatosensory evoked potentials (SSEP) were normal at the time of diagnosis. However, seven patients tested after at least five months of therapy had prolonged central conduction times. We conclude that infants with relatively mild CH (serum T4 values greater than 4 micrograms/dl at 3-8 weeks of age) have evidence of delayed visual system maturation that becomes normal even without treatment and of abnormal caudal brainstem development that resolves slowly with replacement therapy.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionsupporting

confidence: 83%

Evoked Potentials Show Early and Delayed Abnormalities in Children with Congenital Hypothyroidism*

Cavallo

1989

Neuropediatrics

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“…Lipemia and cholesterolemia were determined with the help of classical biochemical analysis, on blood collected a jeune, under identical conditions for all subjects and at the same time of the day. The basal metabolism was determined under rigorously kept basic conditions, through a modern device [30,39]. The Achilean reflexogram was recorded with an efficient dedicated electronic device, and by classic clinical methods the cardiac frequency and the minimum and maximum blood pressure were measured, in a state of basal rest, at the same time of the day.…”

Section: Experimental Part Materials and Methodsmentioning

confidence: 99%

Changes of Visual Evoked Potentials in Patients with Thyroid Dysfunction

Taisescu¹,

Biciuşcă²,

Sas³

et al. 2019

Rev. Chim.

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The visual evoked potentials technique records the cerebral bioelectric activity generated by light stimulation. Evoked potentials is a good method of assessing the electrical response of the brain to different stimuli and has been used extensively in the study of brain disturbances. We registered VEP on 18 hyperthyroid and 18 hypothyroid patients, without other endocrine, metabolic, ophthalmologic or neurological illnesses, the 2 groups having practically identical ages, but sex repartition, illness age and treatment duration being statistically different (p[0.001). Hormonal, radiological, biochemical dosages and physiological paraclinic determinations were performed on all 36 subjects, through classical methods, and VEP recordings, with a 4 channel polygraph through pattern reversal stimulation (1 Hz), measuring all parameters (latency, amplitude, duration, surface, steepness etc.) of N75 and P100 waves. Between groups, the recorded hormone levels and other recordings showed great differences, very highly statistically significant (p[0.001), only arterial pressures being just statistically significant (p[0.05). The Pearson�s r correlation coefficients indicated extremely high correlations (r=0.90-0.98) between all parameters. Between the 2 groups, hypothyroid patients had latencies of P100 wave higher with 17.88% (p=0.0028) and of the N75 wave with 9.98% (p=0.016), and the duration of the N75 wave lower with 26.37% (p=0.026), the other parameters of VEP waves modifying up to 52.35%, not statistically sgnificant due to high standard deviations. The duration of N75 correlates with the majority of humoral-paraclinical parameters, indicating a functional interdependency between them and the function of the cortex. The ratio of the amplitudes and of the areas of P100/N75 indicate a severe inhibition to hypothyroid patients, a precisely quantified reduction of the cerebral activity.

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“…SEPs, and back-averaging, so that its mechanism can be ascertained and compared with that in other cases in the literature. Several studies of SEPs in HD have been performed over the last three decades (19)(20)(21)(22)(23). The extent of scalp recording electrode coverage and choice of reference electrode have differed among these studies, but nearly all these results show a reduction in amplitude with dispersion of short latency (20-40 ms) cortical waveforms in frontal and parietal distributions.…”

Section: Discussionmentioning

confidence: 97%

Cortical myoclonus in huntington's disease associated with an enlarged somatosensory evoked potential

Caviness

Kurth

1997

Movement Disorders

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We report the electrophysiologic findings of myoclonus in a patient with Huntington's disease (HD). This patient was studied postoperatively after a bilateral fetal cell transplant in his striatum. Incomplete transient improvement was seen in the myoclonus, followed by gradual deterioration. The myoclonus itself had a cortical correlate and was associated with an enlarged somatosensory evoked potential (SEP), consistent with the presence of cortical reflex myoclonus. An enlarged SEP has not been previously reported in myoclonus associated with HD. The postulated mechanisms for myoclonus, when it occurs in HD, have differed in the literature. The reason for the transient improvement of the myoclonus following transplantation is unclear, but this case raises the possibility that basal ganglia circuits may modulate cortical myoclonic activity.

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Somatosensory and visual evoked potentials in hyperthyroidism

Cited by 19 publications

References 15 publications

Evoked Potentials Show Early and Delayed Abnormalities in Children with Congenital Hypothyroidism*

Evoked Potentials Show Early and Delayed Abnormalities in Children with Congenital Hypothyroidism*

Changes of Visual Evoked Potentials in Patients with Thyroid Dysfunction

Cortical myoclonus in huntington's disease associated with an enlarged somatosensory evoked potential

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