Somatosensory and trigeminal pathway abnormalities in Chinese patients with trigeminal neuralgia

Li, Yuzhou; Yang, Guoyi; Zhai, Xinli; Kang, Yanfeng; Xie, Qiu-Fei

doi:10.1007/s10266-022-00737-1

Odontology

2022

DOI: 10.1007/s10266-022-00737-1

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Somatosensory and trigeminal pathway abnormalities in Chinese patients with trigeminal neuralgia

Yuzhou Li

Guoyi Yang²,

Xinli Zhai

et al.

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Cited by 3 publications

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“…Частота встречаемости бруксизма, по данным ВОЗ, приближается к показателю 4 человека на 100 000 населения [8]. Отмечают, что чаще всего у пациентов невралгии тройничного нерва имеют правостороннюю латерализацию и возникают вследствие сосудистых, эндокринно-обменных, аллергических и психических расстройств [9][10][11]. При прогрессировании отмечают нарушения процессов формирования памяти и концентрации внимания.…”

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Morphostructural changes in the brain of experimental animals after using mesenchymal stem cells in the temporomandibular joint inflammation model

Pashkevich,

Rubnikovich,

Kuznetsova

et al. 2023

Vescì Nac. akad. navuk Belarusì, Ser. med. navuk

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The article presents the results of structural and functional transformations in cerebellum, trigeminal nuclei, and hippocampus of male Wistar rats against the background of injection of mesenchymal stem cells (MSCs) into Meckel’s space in the temporomandibular joint (TMJ) inflammation model.The aim of the study was to clarify the effect of MSCs injections into Meckel’s space on the morphostructural features of cerebellum, trigeminal nuclei, and hippocampus in the TMJ inflammation model.Injecting the mesenchymal stem cells into Meckel’s space in an inflammatory model of the right lower temporomandibular joint promotes the structure restoration of the ganglionic layer of the cerebellum, the spinal nuclei of the trigeminal nerve, and the hippocampus of rats by the 28th day. This is manifested in increasing the neuronal density, decreasing the neurodegeneration index, and in activating glia elements.

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unclassified

Morphostructural changes in the brain of experimental animals after using mesenchymal stem cells in the temporomandibular joint inflammation model

Pashkevich,

Rubnikovich,

Kuznetsova

et al. 2023

Vescì Nac. akad. navuk Belarusì, Ser. med. navuk

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Pain and sensory disorders after removal of mandibular third molars

Maximova,

Suanova

2024

Medicinskij sovet

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Introduction. Extraction of mandibular third molars is one of the most common oral surgical procedures.Aim. To evaluate the efficacy of B Complex Preparation on pain and sensory problems related to inferior alveolar nerve damage after surgical removal of mandibular third molars.Materials and methods. In the open-label comparative trial 86 patients aged 45 to 54 years with sensory disturbances, lasting 72 hours, after surgical removal of mandibular third molar were included. Pain intensity was assessed using a visual analogue scale (VAS). Quantitative sensory testing (QST) was performed with the computer-controlled Thermal Sensory Analyzer (TSA type II, Medoc Ltd., Ramat Yishai, Israel) with contact thermode (30 × 30 mm). Patients with inferior alveolar nerve damage were divided into 2 groups: the first group – 44 patients received the standart therapy in combination with B Complex Preparation for 30 days, in the second group 42 patients received the standart treatment.Results. After a course of treatment in the first group (B Complex Preparation) was determined the relieving of numbness and pain in 90.9% of patients with inferior alveolar nerve damage. The pain intensity in VAS reduced from 6.3 ± 0.9 to 0.8 ± 0.2 points (p = 0.02) in the first group and from 6.1 ± 0.6 to 4.8 ± 0.4 points (p = 0.09) in the second group. Only in the first group there was a decrease of the warm sensation threshold during QST, which additionally confirms the positive therapeutic effect of B Complex Preparation.Conclusion. Effectiveness of therapy with B Complex Preparation was noted in patients with algic manifistations and sensory disorders after the removal of the third molar.

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Preclinical orofacial pain assays and measures and chronic primary orofacial pain research: where we are and where we need to go

et al. 2023

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Chronic primary orofacial pain (OFP) conditions such as painful temporomandibular disorders (pTMDs; i.e., myofascial pain and arthralgia), idiopathic trigeminal neuralgia (TN), and burning mouth syndrome (BMS) are seemingly idiopathic, but evidence support complex and multifactorial etiology and pathophysiology. Important fragments of this complex array of factors have been identified over the years largely with the help of preclinical studies. However, findings have yet to translate into better pain care for chronic OFP patients. The need to develop preclinical assays that better simulate the etiology, pathophysiology, and clinical symptoms of OFP patients and to assess OFP measures consistent with their clinical symptoms is a challenge that needs to be overcome to support this translation process. In this review, we describe rodent assays and OFP pain measures that can be used in support of chronic primary OFP research, in specific pTMDs, TN, and BMS. We discuss their suitability and limitations considering the current knowledge of the etiology and pathophysiology of these conditions and suggest possible future directions. Our goal is to foster the development of innovative animal models with greater translatability and potential to lead to better care for patients living with chronic primary OFP.

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Somatosensory and trigeminal pathway abnormalities in Chinese patients with trigeminal neuralgia

Cited by 3 publications

References 42 publications

Morphostructural changes in the brain of experimental animals after using mesenchymal stem cells in the temporomandibular joint inflammation model

Morphostructural changes in the brain of experimental animals after using mesenchymal stem cells in the temporomandibular joint inflammation model

Pain and sensory disorders after removal of mandibular third molars

Preclinical orofacial pain assays and measures and chronic primary orofacial pain research: where we are and where we need to go

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