Somatization in the Conceptualization of Sickle Cell Disease

Wellington, Chante; Edwards, Christopher L.; McNeil, Janice; Crisp, Benjamin; Feliu, Miriam; Byrd, Goldie S.; McDougald, Camela; Edwards, Lekisha; Whitfield, Keith E.

doi:10.1016/s0027-9684(15)30736-7

Cited by 6 publications

(8 citation statements)

References 31 publications

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“…While we showed that somatization, even after exclusion of pain items, was associated with decreased HRQoL, we did not see a direct relationship with pain. Somatization has been shown to be associated with pain intensity 59 and health care utilization in SCD, 41 but we did not observe these associations. We did, however, observe a trend toward significant correlation between somatization and pain interference in SCD.…”

Section: Discussioncontrasting

confidence: 89%

Pain catastrophizing is associated with poorer health-related quality of life in pediatric patients with sickle cell disease

Bakshi¹,

Lukombo²,

Belfer³

et al. 2018

JPR

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BackgroundSickle cell disease (SCD) is an inherited disorder of the red blood cells and is associated with chronic multisystem involvement. While SCD has been associated with poorer health-related quality of life (HRQoL), there is a paucity of data on the relationship of psychological covariates other than anxiety and depression and quality of life (QoL) in children with SCD.Materials and methodsWe performed a cross-sectional study of psychological factors, HRQoL, and pain-related outcomes in participants with SCD and race-matched controls as part of a larger study of experimental pain phenotyping.ResultsPain catastrophizing was inversely correlated with HRQoL measured by the PedsQL™ Generic Core Scale in children with SCD, while this was not noted in control participants. Psychological factors, such as anxiety and depressive symptoms, were also associated with poorer HRQoL in both children with SCD and controls. We did not find an association of psychological factors with prior health care utilization. Psychological factors such as anxiety and depressive symptoms were inversely correlated with pain interference, but not pain intensity in SCD.ConclusionCatastrophizing is associated with poorer HRQoL in SCD, but in this study, it was not associated with pain intensity or interference and health care utilization in children with SCD. Further studies are needed to fully define the association of psychological factors including catastrophizing with QoL, pain burden, and SCD outcomes.

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Section: Discussioncontrasting

confidence: 89%

Pain catastrophizing is associated with poorer health-related quality of life in pediatric patients with sickle cell disease

Bakshi¹,

Lukombo²,

Belfer³

et al. 2018

JPR

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“…Furthermore, our cross-sectional analysis did not include a measure of somatization which may be a confounding variable in assessing the prevalence of depression in this population. Studies now suggest that somatization, an overwhelming attention to bodily symptoms, in SCD patients is predictive of negative psychological outcomes including depression, anxiety and hostility [19,37]. …”

Section: Discussionmentioning

confidence: 99%

Sleep disturbance, depression and pain in adults with sickle cell disease

et al. 2014

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BackgroundSleep disturbance and depression are commonly encountered in primary care. In sickle cell disease, depression is associated with pain, poor treatment compliance, and lower quality of life. The prevalence of sleep disturbance and its effect upon quality of life in adults with sickle cell disease is unknown. The goal of this study was to determine the prevalence of sleep disturbance and if it is associated with pain and depression in sickle cell disease.MethodsThree hundred twenty eight adults with sickle cell disease enrolled on the Bethesda Sickle Cell Cohort Study were assessed using the Pittsburgh Sleep Quality Index and Beck Depression Inventory II screening measures as a cross-sectional survey. Scores greater than 5 (Pittsburgh Sleep Quality Index) and 16 (Beck Depression Inventory II) defined sleep disturbance and depression, respectively. Clinical and laboratory parameters were also assessed.ResultsThe mean Pittsburgh Sleep Quality Index score was 8.4 (SD ± 4.2) indicating a 71.2% prevalence of sleep disturbance. The mean Beck Depression Inventory II score was 8.0 (SD ± 8.9). Sixty five (20.6%) participants had a score indicating depression, and half of these (10.0%) had thoughts of suicide. Both Pittsburgh Sleep Quality Index and Beck Depression Inventory II scores were significantly correlated (p < .001). The number of days with mild/moderate pain (p = .001) and a history of headaches (p = .005) were independently associated with depression by multivariate regression analysis. Patients with sleep disturbance were older (p = .002), had higher body mass index (p = .011), had more days of pain (p = .003) and more frequent severe acute painful events (emergency room visits and hospitalizations) during the previous 12 months (p < .001).ConclusionsMore than 70 percent of adults with sickle cell disease had sleep disturbance, while 21 percent showed evidence of clinical depression. Sleep disturbance and depression were correlated, and were most common among those with more frequent pain. Providers caring for adults with sickle cell disease and frequent pain should consider screening for these common co-morbidities. Additional study is needed to confirm these findings and to determine if treatments for pain, depression or sleep disturbances will improve quality of life measures in this patient population.Trial registrationClinicalTrials.gov identifier: NCT00011648.

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“…In a study examining anxiety and depressive symptoms as mediators between perceived stress and frequency of pain episodes, anxiety but not depressive symptoms significantly explained the mediating effect 119 . Somatization, pathological attention to bodily symptoms , has also been associated with anxiety in SCD 120 . Anxiety symptoms even predict pain and opioid use following successful HCT.…”

Section: Intersections Of Psychiatry and Pain In Sickle Cell Diseasementioning

confidence: 99%

“…119 Somatization, pathological attention to bodily symptoms, has also been associated with anxiety in SCD. 120 Anxiety symptoms even predict pain and opioid use following successful HCT. Adults with SCD with higher scores for anxiety on PROMIS measures before HCT were at higher risk for continued pain and opioid use 1 year after successful HCT.…”

Section: N Ter Sec Tions Of Psychi Atry a N D Pa I N I N Sick L E Ce ...mentioning

confidence: 99%

Psychiatric comorbidities in adults with sickle cell disease: A narrative review

Mishkin

Prince²,

Leimbach

et al. 2023

Br J Haematol

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SummaryAlthough descriptions of quality of life and patient reports of mood in sickle cell disease (SCD) have become more common in the literature, less is known about psychiatric illness prevalence, presentation, and treatment, particularly for adults. We provide a narrative review of what is known about common and debilitating psychiatric conditions such as depression, anxiety, and cognitive impairment, specifically for adults with SCD. We discuss the limitations of the current evidence, make provisional recommendations, and identify opportunities for research and improved care.

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Somatization in the Conceptualization of Sickle Cell Disease

Cited by 6 publications

References 31 publications

Pain catastrophizing is associated with poorer health-related quality of life in pediatric patients with sickle cell disease

Pain catastrophizing is associated with poorer health-related quality of life in pediatric patients with sickle cell disease

Sleep disturbance, depression and pain in adults with sickle cell disease

Psychiatric comorbidities in adults with sickle cell disease: A narrative review

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