Somatic Symptoms in Primary Affective Disorder

Rc, Casper; De, Redmond; Mm, Katz; Schaffer, Chris B.; Jm, Davis; Sh, Koslow

doi:10.1001/archpsyc.1985.01790340082012

Cited by 257 publications

(40 citation statements)

References 44 publications

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“…Decreased libido commonly accompanies an episode of major depression. Casper et al [34], in the classic study on a sample of moderate to severe hospitalized drug-free patients with major affective disorder, found that the majority of these patients (72% of unipolar depressed, 77% of bipolar depressed) experienced loss of sexual interest. Increasing severity of depression and anxiety were associated with loss of libido.…”

Section: Sexual Dysfunction In Patients Suffering From Depressionmentioning

confidence: 99%

The Impact of Mental Illness on Sexual Dysfunction

Zemishlany

Weizman²

2008

Advances in Psychosomatic Medicine

158

101

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Sexual dysfunction is prevalent among psychiatric patients and may be related to both the psychopathology and the pharmacotherapy. The negative symptoms of schizophrenia limit the capability for interpersonal and sexual relationships. The first-generation antipsychotics cause further deterioration in erectile and orgasmic function. Due to their weak antagonistic activity at D2 receptors, second-generation antipsychotics are associated with fewer sexual side effects, and thus may provide an option for schizophrenia patients with sexual dysfunction. Depression and anxiety are a cause for sexual dysfunction that may be aggravated by antidepressants, especially selective serotonin reuptake inhibitors (SSRIs). SSRI-induced sexual dysfunction may be overcome by lowering doses, switching to an antidepressant with low propensity to cause sexual dysfunction (bupropion, mirtazapine, nefazodone, reboxetine), addition of 5HT2 antagonists (mirtazapine, mianserin) or coadministration of 5-phosphodiesterase inhibitors. Eating disorders and personality disorders, mainly borderline personality disorder, are also associated with sexual dysfunction. Sexual dysfunction in these cases stems from impaired interpersonal relationships and may respond to adequate psychosexual therapy. It is mandatory to identify the specific sexual dysfunction and to treat the patients according to his/her individual psychopathology, current pharmacotherapy and interpersonal relationships.

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Section: Sexual Dysfunction In Patients Suffering From Depressionmentioning

confidence: 99%

The Impact of Mental Illness on Sexual Dysfunction

Zemishlany

Weizman²

2008

Advances in Psychosomatic Medicine

158

101

View full text Add to dashboard Cite

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“…Somatic symptoms can be the first sign of a depressive episode (Beck, 1967) and are often the first and only symptoms presented in primary care settings (Kirmayer, 2001; Tylee & Ghandi, 2005). In addition, the presence and disappearance of somatic symptoms often correlates with the severity and remittance of depression (Beck, 1967; Casper et al, 1985; Fava et al, 1997; Paykel et al, 1995). …”

mentioning

confidence: 99%

Interoceptive dysfunction: Toward an integrated framework for understanding somatic and affective disturbance in depression.

Harshaw

2015

Psychological Bulletin

221

147

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Depression is characterized by disturbed sleep and eating, a variety of other, nonspecific somatic symptoms, and significant somatic comorbidities. Why there is such close association between cognitive and somatic dysfunction in depression is nonetheless poorly understood. An explosion of research in the area of interoception—the perception and interpretation of bodily signals—over the last decade nonetheless holds promise for illuminating what have until now been obscure links between the social, cognitive-affective, and somatic features of depression. This paper reviews rapidly accumulating evidence that both somatic signaling and interoception are frequently altered in depression. This includes comparative studies showing vagus-mediated effects on depression-like behaviors in rodent models as well as studies in humans indicating both dysfunction in the neural substrates for interoception (e.g., vagus, insula, anterior cingulate cortex) and reduced sensitivity to bodily stimuli in depression. An integrative framework for organizing and interpreting this evidence is put forward which incorporates (a) multiple potential pathways to interoceptive dysfunction; (b) interaction with individual, gender, and cultural differences in interoception; and (c) a developmental psychobiological systems perspective, emphasizing likely differential susceptibility to somatic and interoceptive dysfunction across the lifespan. Combined with current theory and evidence, it is suggested that core symptoms of depression (e.g., anhedonia, social deficits) may be products of disturbed interoceptive-exteroceptive integration. More research is nonetheless needed to fully elucidate the relationship between mind, body, and social context in depression.

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“…Toutefois et bien que la dépression soit plus prévalente chez les femmes, la majorité des études ayant évalué la sexualité des personnes dépressives ont été réalisées auprès des hommes (v.g., Bancroft, Janssen, Strong, Carnes, Vukadinovic & Long, 2003;Howell et al, 1987;Low, Khoo, Tan, Hew & Teoh, 2006;Meisler & Carey, 1991) ou ont été réalisées auprès d'hommes et de femmes mais sans présenter les résultats de façon distinctive en fonction du sexe (Casper, Redmond, Katz, Schaffer, Davis & Koslow, 1985;Davidson, Krishnan, France & Pelton, 1985). Au total, onze études ont évalué et ont rapporté des données sur la sexualité des femmes présentant des symptômes dépressifs.…”

Section: Sexualité Des Femmes Ayant Des Symptômes Dépressifsunclassified

Sexualité et satisfaction conjugale des femmes ayant des symptômes dépressifs :

Gagné¹

2011

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Somatic Symptoms in Primary Affective Disorder

Cited by 257 publications

References 44 publications

The Impact of Mental Illness on Sexual Dysfunction

The Impact of Mental Illness on Sexual Dysfunction

Interoceptive dysfunction: Toward an integrated framework for understanding somatic and affective disturbance in depression.

Sexualité et satisfaction conjugale des femmes ayant des symptômes dépressifs :

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