Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats

Yarushkina, Natalia; Bogdanov, A I; Filaretova, Ludmila

doi:10.1016/j.autneu.2006.02.009

Cited by 16 publications

(9 citation statements)

References 28 publications

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“…A growing attention to quality of life has accelerated the scientific interests to dyspeptic symptoms. Among them, mechanisms of symptoms generation and management strategy of the GI symptoms have been particularly attracted both clinical and basic interests 17–19 . Generally, multiple factors are considered to be involved for dyspeptic symptom generation.…”

Section: Discussionmentioning

confidence: 99%

Generation of dyspeptic symptoms by direct acid infusion into the stomach of healthy Japanese subjects

Miwa

Nakajima

Yamaguchi

et al. 2007

Aliment Pharmacol Ther

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SUMMARY ObjectiveThe relationship between acid and dyspeptic symptoms has not been fully understood. AimTo investigate the type and severity of dyspeptic symptoms induced by direct acid infusion into the stomach of Japanese healthy subjects. MethodsThis was a multi-centre, cross-over, randomized, double-blind study in 27 healthy subjects (mean age 27). Each fasted subject received two tests with 150 mL of 0.1 mol ⁄ L hydrochloric acid infusion (15 mL ⁄ min for 10 min) and the same volume of pure water infusion. The type and severity of symptoms were assessed by a 10 cm visual analogue scale administered every 2 min up to 30 min. ResultsVarious symptoms were reported after both acid and water infusions. Most of the symptoms were more severe after acid infusion compared with water infusion (acid vs. water: discomfort 1.8 AE 0.4 vs. 0.5 AE 0.1, pain 0.6 AE 0.3 vs. 0.1 AE 0.1, reflux 1.0 AE 0.3 vs. 0.3 AE 0.1 and satiety 1.1 AE 0.4 vs. 0.2 AE 0.1). The area under curve for dysmotility like symptoms (heavy feeling in the stomach, bloating, nausea or feeling sick, and belching) was significantly higher in acid infusion, and symptoms continued after infusion of the acid. ConclusionAcid induced into stomach induced dysmotility-like predominant dyspeptic symptoms in Japanese healthy control subjects, demonstrating the possible importance of acid in symptom generation.

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Section: Discussionmentioning

confidence: 99%

Generation of dyspeptic symptoms by direct acid infusion into the stomach of healthy Japanese subjects

Miwa

Nakajima

Yamaguchi

et al. 2007

Aliment Pharmacol Ther

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“…The current varied from 0.07 to 2 mA with an increment of 70 A [1][2][3]. The latency was estimated as the interval from the start of exposure of the ventral surface of the tail to a focused light beam [14] to the tail-fl ick reaction.…”

Section: Methodsmentioning

confidence: 99%

Effect of Glucocorticoid Receptor Blockade on Analgesic Effect of Corticotropin-Releasing Factor

2011

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“…In addition to spontaneous pain, visceral pain can also alter somatic sensitivity causing referred hyperalgesia (Traub and Wang, 2004;Yarushkina et al 2006). For instance, rats with induced gastric ulcers were found to have a lower nociceptive response threshold to thermal stimulation of the tail (Yarushkina et al 2006). Indeed, Taylor (2006) reports that pigs with acute gastric ulcers are more sensitive to pressure applied to the xiphoid process.…”

Section: Discussionmentioning

confidence: 99%

A study of associations between gastric ulcers and the behaviour of finisher pigs

Rutherford

Thompson

Thomson³

et al. 2018

Livestock Science

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Gastric ulcers are a common condition in finisher pigs. A study was conducted to investigate the hypothesis that gastric ulceration alters the behaviour of finisher pigs. Two one-hour observations (from video recordings) of home pen behaviour were conducted in finisher pigs, at two farms (one in Denmark and one in Scotland), in the days immediately prior to slaughter. Stomach condition was assessed post mortem according to a pre-established ulcer score index. The behaviour of pigs with healthy stomachs (n=36) was compared with the behaviour of pigs with deep ulceration of the pars oesophagea (n=26). Assessment of various predefined postures and behaviours was made by an observer blind to the gastric ulcer status of the observed pigs. Behavioural data from the two sites were combined in a single analysis. Pigs with gastric ulcers tended to spend less time idle (P=0.081) and less time lying on their left side (P=0.064), and significantly more time standing (P=0.009), or walking (P=0.038) compared to healthy pigs. Pigs with ulcers also showed an increased frequency of posture changes (P=0.02). A decrease in time spent lying on the left and an increase in standing/walking could both be interpreted as attempts to avoid liquid gastric contents pooling in the cranial region of the stomach. This along with the higher level of posture changes observed may indicate some degree of pain/discomfort associated with the presence of gastric ulcers in pigs. This study is the first to identify apparent behavioural differences between finisher pigs with or without gastric ulcers, and further work is needed to establish to what extent the apparent behavioural differences are a consequence of pain or discomfort for the animals concerned. Since gastrooesophageal ulceration of pigs is associated with pelleting and fine grinding of feed which in turn is linked to increased growth efficiency there may be a dilemma between on one hand concern for preventing gastric ulcers and on the other hand concern for the efficiency and sustainability of pig production.

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Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats

Cited by 16 publications

References 28 publications

Generation of dyspeptic symptoms by direct acid infusion into the stomach of healthy Japanese subjects

Generation of dyspeptic symptoms by direct acid infusion into the stomach of healthy Japanese subjects

Effect of Glucocorticoid Receptor Blockade on Analgesic Effect of Corticotropin-Releasing Factor

A study of associations between gastric ulcers and the behaviour of finisher pigs

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