2019
DOI: 10.1101/511790
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Somatic mutation landscape reveals differential variability of cell-of-origin for primary liver cancer

Abstract: 21Background: Primary liver tissue cancers display consistent increase in global disease burden 22 and mortality. Identification of cell-of-origins for primary liver cancers would be a necessity 23 to expand options for designing relevant therapeutics and preventive medicine for these cancer 24 types. Previous reports on cell-of-origin for primary liver cancers was mainly from animal 25 studies, and integrative research utilizing human specimen data was poorly established. 26Methods: We analyzed a whole-… Show more

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