Somatic Movement and Oesophageal Motility During Isoflurane Anaesthesia

Mather, Cheryl; Raftery, S.; Prys‐Roberts, C.

doi:10.1093/bja/69.1.40

Cited by 12 publications

(11 citation statements)

References 16 publications

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“…Evans et al suggested that monitoring oesophageal motility could be used as a measure of anaesthetic depth [5], and indeed subsequent studies have shown that the presence of lower oesophageal contractions may well indicate too light anaesthesia. However, routine abolition of the contractions may well lead to a large number of patients being unnecessarily deeply anaesthetized [6].…”

Section: Non-eeg Related Monitoringmentioning

confidence: 99%

The Value to the Anaesthetist of Monitoring Cerebral Activity

Langford

Thomsen²

1994

Methods Inf Med

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Abstract:The administration rate of general anaesthetic drugs is at present guided by clinical experience, and indirect indicators such as haemodynamic parameters. In the presence of muscle relaxants most of the clinical signs of inadequate anaesthesia are lost and accidental awareness may occur. A number of monitoring modalities, primarily based on analysis of the electroencephalogram (EEG), have been proposed for measurement of the anaesthetic depth. Moreover intraoperative cerebral monitoring may also provide the anaesthetist with early warning of cerebral ischaemia, or information on specific neurological pathways. To facilitate this, it is essential to combine analysis of the spontaneous EEG with recording of evoked potentials, to assess both cortical and subcortical activity/events. None of the reviewed methods, however promising, can alone meet all of the requirements for intraoperative monitoring of cerebral function. We suggest that the future direction should be to integrate several modalities in a single device, to provide valuable new information, upon which to base clinical management decisions.

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Section: Non-eeg Related Monitoringmentioning

confidence: 99%

The Value to the Anaesthetist of Monitoring Cerebral Activity

Langford

Thomsen²

1994

Methods Inf Med

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“…Anaesthetic dose-response data in humans were reported by deJong and Eger for halothane 12 , and by Mather, Raftery and Prys-Roberts for isoflurane 13 . For halothane, figure 4 shows the Hill curves for various n values, where xm:0.75 %atm :0.24 mmol litre 91 , together with the data points 12 .…”

Section: In Vivo Dose-responsementioning

confidence: 85%

“…5) In contrast, the in vivo dose-response curve exhibited a much lesser slope for isoflurane. A least-square fitting of the data points 13 to equation 2…”

Section: In Vivo Dose-responsementioning

confidence: 99%

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Dose-response curve for anaesthetics based on the Monod-Wyman-Changeux model

Iwai

Kihara

Imaiand

et al. 1996

British Journal of Anaesthesia

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We have analysed the dose-response curve for halothane and isoflurane according to the Monod-Wyman-Changeux (MWC) model. This model describes the nature of the physiological data reported by Wakamori, Ikemoto and Akaike for inhibitory Cl currents induced by GABA or glycine in dissociated rat brain neurones and by Herrington and colleagues for Ca2+ currents in clonal pituitary cells. With some assumptions on the difference in response to anaesthetics between patients, the model is applicable in vivo, and it also describes well the human dose-response curve for isoflurane reported by Mather, Raftery and Prys-Roberts. However, the steeply sigmoidal dose-response curve in humans for halothane presented by deJong and Eger is difficult to understand with the same model, because it gives rise to unrealistic MWC variables.

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“…A limitation of the swine model was that peristalsis had not been observed in either endoscopy or OCT. The suppression of peristalsis was likely caused by the Isoflurane [32,33]. General anesthesia of the animal was necessary to avoid the otherwise intense body movement.…”

Section: Discussionmentioning

confidence: 99%

Motion artifacts associated with in vivo endoscopic OCT images of the esophagus

Kang

Wang

et al. 2011

Opt. Express

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3-D optical coherence tomography (OCT) has been extensively investigated as a potential screening and/or surveillance tool for Barrett’s esophagus (BE). Understanding and correcting motion artifact may improve image interpretation. In this work, the motion trace was analyzed to show the physiological origin (respiration and heart beat) of the artifacts. Results showed that increasing balloon pressure did not sufficiently suppress the physiological motion artifact. An automated registration algorithm was designed to correct such artifacts. The performance of the algorithm was evaluated in images of normal porcine esophagus and demonstrated in images of BE in human patients.

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Somatic Movement and Oesophageal Motility During Isoflurane Anaesthesia

Cited by 12 publications

References 16 publications

The Value to the Anaesthetist of Monitoring Cerebral Activity

The Value to the Anaesthetist of Monitoring Cerebral Activity

Dose-response curve for anaesthetics based on the Monod-Wyman-Changeux model

Motion artifacts associated with in vivo endoscopic OCT images of the esophagus

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