Somatic Mitochondrial DNA Mutations in Oral Cancer of Betel Quid Chewers

D, Tan; Chang, Julia; Chen, Woan-Ling; Agress, Lesley J.; Yeh, Kun‐Tu; Wang, Bao-Tyan; Wong, Lee‐Jun C.

doi:10.1007/978-3-662-41088-2_30

Cited by 5 publications

(18 citation statements)

References 14 publications

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“…Tobacco carcinogens are known source of oxidative stress and thus may have central role in promoting mitochondrial genomic instability. 10,12,13 All our subjects had history of tobacco consumption. Therefore any alteration in polycytosine site is a result of mitochondrial genomic instability, and therefore it may have a role in the dysregulation of mtDNA functioning, for example alterations in energy metabolism may promote tumor development.…”

Section: Discussionmentioning

confidence: 99%

Additional cytosine inside mitochondrial C-tract D-loop as a progression risk factor in oral precancer cases

Pandey

Mehrotra

Mahdi

et al. 2014

Journal of Oral Biology and Craniofacial Research

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Section: Discussionmentioning

confidence: 99%

Additional cytosine inside mitochondrial C-tract D-loop as a progression risk factor in oral precancer cases

Pandey

Mehrotra

Mahdi

et al. 2014

Journal of Oral Biology and Craniofacial Research

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“…Most of the mtDNA mutations are located in the D-loop region of mtDNA. To date, only two studies pointed out that 56.7-66.7% of the oral squamous cell carcinoma cases had somatic mutations in the D-loop of mtDNA [7,8]. However, the relationship between somatic mutations of the D-loop of mtDNA and prognosis of oral cancer patients has never been reported.…”

Section: Introductionmentioning

confidence: 93%

Somatic mutations in the D-loop of mitochondrial DNA in oral squamous cell carcinoma

Liu

Jiang

Chen³

et al. 2011

Eur Arch Otorhinolaryngol

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We aimed to characterize somatic mutations in the D-loop of mitochondrial DNA (mtDNA) and their impact on survival in oral squamous cell carcinoma patients in an endemic betel quid chewing area. Histologically confirmed oral cancer and corresponding non-tumor tissues were obtained from 59 patients. The D-loop of mtDNA sequence in a patient's non-cancerous tissues was compared with that of paired oral cancer samples and any sequence differences were identified as somatic mutations. With a median follow-up of 16 months, somatic mutations of the D-loop were observed in 38 (64.4%) patients and most of them occurred in the poly-C tract. There was no significant difference between the mutation group and non-mutation group in age, gender, primary site, histological features, pathological stage, smoking, betel quid chewing, alcohol consumption, and postoperative radiotherapy. However, patients with D-loop mutations have better survival (2 year disease specific survival rate: 73.4 vs. 45.0%, P = 0.0374). A high rate of somatic mutations in the D-loop region of mtDNA was found in betel quid-related oral squamous cell carcinoma patients. Somatic mutation of D-loop of mtDNA was associated with better survival.

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“…Of 45 colorectal carcinomas tested, 3 contain ND1 and 3 ND5 gene mutations [51]. Of 18 primary oral squamous cell carcinomas tested, 3 contain ND2, 1 ND3, and 1 ND4 somatic mutations [52]. In a series of 15 patients with renal oncocytoma and compromised complex I function, 4 patients harbor ND1, 3 patients ND4, and 3 patients ND5 sequence alterations.…”

Section: Alterations In Nd Genesmentioning

confidence: 99%

“…In 10 colorectal cancer cell lines, 1 COXI, 1 COXII, and 1 COXIII sequence alterations are present [50]. Of 18 oral squamous cell carcinomas, 1 contains a COXIII somatic mutation [52]. In 31 urothelial cell carcinoma patients, tumor cells are found to contain altered sequence in COXI (n = 2) and COXIII (n = 2) genes [53].…”

Section: Alterations In Cox Genesmentioning

confidence: 99%

“…Intriguingly, the most frequent mtDNA alterations in human cancers are in fact located in the D-loop region [61]. mtDNA alterations within the Dloop could be detected in 77% [52] or 64% [62] of oral squamous cell carcinomas and 44% of colorectal carcinomas (n = 45) [51]. Of 9 renal cell tumors tested, 3 contain Dloop sequence changes [63].…”

Section: Mtdna Displacement-loop Alterationsmentioning

confidence: 99%

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Mitochondrial Markers for Cancer: Relevance to Diagnosis, Therapy, and Prognosis and General Understanding of Malignant Disease Mechanisms

Paepe

2012

ISRN Pathology

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Cancer cells display changes that aid them to escape from cell death, sustain their proliferative powers, and shift their metabolism toward glycolytic energy production. Mitochondria are key organelles in many metabolic and biosynthetic pathways, and the adaptation of mitochondrial function has been recognized as crucial to the changes that occur in cancer cells. This paper zooms in on the pathologic evaluation of mitochondrial markers for diagnosing and staging of human cancer and determining the patients’ prognoses.

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Somatic Mitochondrial DNA Mutations in Oral Cancer of Betel Quid Chewers

Cited by 5 publications

References 14 publications

Additional cytosine inside mitochondrial C-tract D-loop as a progression risk factor in oral precancer cases

Additional cytosine inside mitochondrial C-tract D-loop as a progression risk factor in oral precancer cases

Somatic mutations in the D-loop of mitochondrial DNA in oral squamous cell carcinoma

Mitochondrial Markers for Cancer: Relevance to Diagnosis, Therapy, and Prognosis and General Understanding of Malignant Disease Mechanisms

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