Somatic KMT2D loss-of-function mutations in lung squamous cell carcinoma: a single-center cohort study
Zekui Fang,
Xiping Wu,
Li Xiao
et al.
Abstract:Background
The significant progress has been made in targeted therapy for lung adenocarcinoma (LUAD) in the past decade. Only few targeted therapeutics have yet been approved for the treatment of lung squamous cell carcinoma (LUSC). Several higher frequency of gene alterations are identified as potentially actionable in LUSC. Our work aimed to explore the complex interplay of multiple genetic alterations and pathways contributing to the pathogenesis of LUSC, with a very low frequency of a single d… Show more
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