Somatic comorbidity, metabolic syndrome, cardiovascular risk, and CRP in patients with recurrent depressive disorders

Topić, Radmila; Miličić, Davor; Štimac, Zoran; Lončar, Mladen; Velagić, Vedran; Marčinko, Darko; Jakovljević, Miro

doi:10.3325/cmj.2013.54.453

Cited by 25 publications

(21 citation statements)

References 11 publications

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“…2 Unfortunately, there is a consensus that depression may contribute to the clinical outcomes in several chronic diseases, such as diabetes, chronic kidney diseases (CKD) and CVD. 2,3 Very recently, a noteworthy prevalence of metabolic syndrome (MS) was observed in patients with depression. 3 Poor blood glucose homeostatic regulation in the body may result in adverse clinical outcomes.…”

Section: Resultsmentioning

confidence: 99%

“…2,3 Very recently, a noteworthy prevalence of metabolic syndrome (MS) was observed in patients with depression. 3 Poor blood glucose homeostatic regulation in the body may result in adverse clinical outcomes. Serum fructosamine is a glycoprotein formed through a nonenzymatic mechanism, and it is clinically used to estimate glycemic control over the previous two to three weeks in patients with diabetes.…”

Section: Resultsmentioning

confidence: 99%

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The relationship between major depressive disorders and glucose parameters: A cross-sectional study in Chinese population

2017

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Background. Depressive symptoms have been linked with insulin resistance in middle-aged and elderly populations. A strong relationship between peripheral insulin resistance and glucose homeostasis imbalance has been well established in previous studies. The role of serum fructosamine and fasting blood glucose (FBG) in elevating glucose homeostasis has been documented in the literature.Objectives. The aim of the study was to examine the association of serum fructosamine and FBG with major depressive disorder (MDD). Material and methods.The study analyzed the clinical characteristics and biochemical parameters of 305 patients with MDD and 312 healthy individuals.Results. Serum concentrations of lipoprotein-cholesterol (HDL-C), total protein (TP) and creatinine (Cr) were found to be significantly different between the two groups. Serum fructosamine and fasting blood glucose (FBG) concentrations were high in patients with MDD compared with healthy individuals (2.3 ± 0.26 vs. 2. 1 ± 0.27, p = 0.018; 4.7 ± 0.45 vs. 4.5 ± 0.45, p < 0.001). The levels of serum fructosamine and FBG were also significantly higher in patients with MDD when all participants were stratified by gender. Age was found to be positively correlated with FBG, serum fructosamine and Cr (r = 0.203, p < 0.001; r = 0. 129, p = 0.025; r = 0. 129, p = 0.024), and negatively correlated with TP (r = -0. 114, p = 0.047) in patients with MDD. However, there were no correlations between age and FBG, serum fructosamine or Cr in the healthy controls. In a multivariate logistic regression analysis, increased serum fructosamine and FBG concentrations were positively associated with MDD independently of age and gender, after adjustment for age and potential confounding factors (OR = 6.313, CI95 %:2.953-13.393, p < 0.001; OR = 2.251, CI95 %: 1.464-3.462, p < 0.001). Conclusions.The study results suggest that increased serum fructosamine and FBG concentrations are associated with depressive conditions, which may influence glucose metabolism and impair glucose homeostasis in patients with MDD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The relationship between major depressive disorders and glucose parameters: A cross-sectional study in Chinese population

2017

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“…Both mental and dermatological disorders are associated with an increased risk of cardiovascular disease. [30][31][32][33] For example, Topic and colleagues 30 found somatic comorbid diseases to be significantly more common in their controlled study of 76 major depressive patients compared to the healthy control group. Cardiovascular disease was most commonly diagnosed at 46.1%, compared to 13.9% in the control group.…”

Section: Cardiovascular Disease In Mentally Ill Patients With Comorbimentioning

confidence: 99%

“…Here, an increase in the C-reactive protein (CRP), an acute-phase protein whose synthesis is increasingly induced after the release of proinflammatory cytokines, was found to be significantly more frequent in the depressive patients than in the control subjects. 30 An elevated CRP level is again being discussed as a risk factor for atherogenesis and metabolic syndrome with an increased risk of myocardial infarction or cerebral insult. 30 In this context, it is not surprising that chronic inflammatory skin diseases are also associated with cardiovascular comorbidities, and this relationship should be of prime interest for researchers, especially in the case of patients with psoriasis.…”

Section: Cardiovascular Disease In Mentally Ill Patients With Comorbimentioning

confidence: 99%

Skin Diseases in Patients with Primary Psychiatric Disorders

Mavrogiorgou

Mersmann

Gerlach

et al. 2020

Psychiatry Investig

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Objective The few psychodermatological studies of primary psychiatric populations so far suggest that parasitic-infectious skin diseases are the most common dermatological comorbidity in more than 70% of psychiatric patients, which should be studied here in a large data bank outside dermatological treatment facilities.Methods In a descriptive-explorative and retrospective study, more than 17,000 patients with primary psychiatric disorders were examined to investigate dermatological comorbidities.Results The proportion of patients with primary mental disorders and additional dermatological disease was 1.24% (n=212). Here, psoriasis (35.4%) and atopic dermatitis (22.6%) were the most frequent dermatological diseases among these 212 patients. Infectious-parasitic skin diseases were present in 13.2% of comorbid patients. The most common mental disorder was a depressive illness, seen in 42.5% (n=90) of patients.Conclusion Our results confirmed the frequent association of depression with psoriasis and atopic dermatitis, indicating the need for the early detection and treatment of such comorbid patients. In contrast, psychiatric inpatients do not appear to suffer from predominantly infectious-parasitic dermatoses.

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“…Therefore, genetic stress-response factors in MDD may also underlie the aetiology of other stress-linked disorders, with which MDD is often co-morbid 47,48 (e.g. cardiovascular diseases 49 , diabetes, 50 chronic pain 51 and inflamation 52 ). We tested the hypothesis that pleiotropy and shared aetiology between mental and physical health conditions may be due in part to genetic variants underlying SLE effects in depression.…”

Section: Introductionmentioning

confidence: 99%

Genome-wide by environment interaction studies (GWEIS) of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland

Soler

Macdonald-Dunlop

Adams

et al. 2018

Preprint

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Stress is associated with poorer physical and mental health. To improve our understanding of this link, we performed genome-wide association studies (GWAS) of depressive symptoms and genome-wide by environment interaction studies (GWEIS) of depressive symptoms and stressful life events (SLE) in two UK population cohorts (Generation Scotland and UK Biobank). No SNP was individually significant in either GWAS, but gene-based tests identified six genes associated with depressive symptoms in UK Biobank (DCC, ACSS3, DRD2, STAG1, FOXP2 and KYNU; p < 2.77×10-6). Two SNPs with genome-wide significant GxE effects were identified by GWEIS in Generation Scotland: rs12789145 (53kb downstream PIWIL4; p = 4.95×10-9; total SLE) and rs17070072 (intronic to ZCCHC2; p = 1.46×10-8; dependent SLE). A third locus upstream CYLC2 (rs12000047 and rs12005200, p < 2.00×10-8; dependent SLE) when the joint effect of the SNP main and GxE effects was considered. GWEIS gene-based tests identified: MTNR1B with GxE effect with dependent SLE in Generation Scotland; and PHF2 with the joint effect in UK Biobank (p < 2.77×10-6). Polygenic risk scores (PRS) analyses incorporating GxE effects improved the prediction of depressive symptom scores, when using weights derived from either the UK Biobank GWAS of depressive symptoms (p = 0.01) or the PGC GWAS of major depressive disorder (p = 5.91×10-3). Using an independent sample, PRS derived using GWEIS GxE effects provided evidence of shared aetiologies between depressive symptoms and schizotypal personality, heart disease and COPD. Further such studies are required and may result in improved treatments for depression and other stress-related conditions.

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Somatic comorbidity, metabolic syndrome, cardiovascular risk, and CRP in patients with recurrent depressive disorders

Cited by 25 publications

References 11 publications

The relationship between major depressive disorders and glucose parameters: A cross-sectional study in Chinese population

The relationship between major depressive disorders and glucose parameters: A cross-sectional study in Chinese population

Skin Diseases in Patients with Primary Psychiatric Disorders

Genome-wide by environment interaction studies (GWEIS) of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland

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