Somatic and Germline Variants and Coronary Heart Disease in a Chinese Population
Kun Zhao,
Xuxiang Shen,
Hongwei Liu
et al.
Abstract:ImportanceThe genetic basis of coronary heart disease (CHD) has expanded from a germline to somatic genome, including clonal hematopoiesis of indeterminate potential (CHIP). How CHIP confers CHD risk in East Asian individuals, especially those with small clones (variant allele fraction [VAF] 0.5%-2%) and different genetic backgrounds, was completely unknown.ObjectiveTo investigate the CHIP profile in a general Chinese cohort by deep sequencing and further explore the association between CHIP and incident CHD c… Show more
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