Solvothermal synthesis and characterization of ytterbium/iron mixed oxide nanoparticles with potential functionalities for applications as multiplatform contrast agent in medical image techniques

Yeste, María Pilar; Fernández-Ponce, Cecilia; Félix, Eduardo; Tinoco, M.; Fernández-Cisnal, Ricardo; García-Villar, C.; Pfaff, Cathrin; Kriwet, Jürgen; Natividad, Eva; Cauqui, M.A.; García-Cozar, Francisco; Litrán, R.; Miguel, Óscar

doi:10.1016/j.ceramint.2022.06.194

Cited by 8 publications

(5 citation statements)

References 47 publications

(53 reference statements)

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“…It has now been proposed that [126] glutathione functionalized ytterbium/iron oxide NPs as a dual-modality contrast agent for MRI/CT imaging. In a major advance, Dong et al [127], for the first time, developed an ultrasmall ytterbium NPs (YbNPs) contrast agent for CT/spectral photon-counting computed tomography (SPECT) imaging.…”

Section: Ytterbium-based Nanoparticlesmentioning

confidence: 99%

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

2023

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In recent years, there has been an increasing interest in using nanoparticles in the medical sciences. Today, metal nanoparticles have many applications in medicine for tumor visualization, drug delivery, and early diagnosis, with different modalities such as X-ray imaging, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), etc., and treatment with radiation. This paper reviews recent findings of recent metal nanotheranostics in medical imaging and therapy. The study offers some critical insights into using different types of metal nanoparticles in medicine for cancer detection and treatment purposes. The data of this review study were gathered from multiple scientific citation websites such as Google Scholar, PubMed, Scopus, and Web of Science up through the end of January 2023. In the literature, many metal nanoparticles are used for medical applications. However, due to their high abundance, low price, and high performance for visualization and treatment, nanoparticles such as gold, bismuth, tungsten, tantalum, ytterbium, gadolinium, silver, iron, platinum, and lead have been investigated in this review study. This paper has highlighted the importance of gold, gadolinium, and iron-based metal nanoparticles in different forms for tumor visualization and treatment in medical applications due to their ease of functionalization, low toxicity, and superior biocompatibility.

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Section: Ytterbium-based Nanoparticlesmentioning

confidence: 99%

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

2023

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“…Ytterbium has also been used as one of the potential candidates for theranostic purposes. The ytterbium/iron oxide NP has emerged as a dual-modality contrasting agent for MRI/CT imaging . Dong et al achieved a pioneering feat by creating an extra small contrast agent composed of ytterbium nanoparticles (YbNPs) for application in CT and spectral photon-counting computed tomography (SPECT) imaging.…”

Section: Nanoparticles Used For Theranostic Purposesmentioning

confidence: 99%

“…The ytterbium/ iron oxide NP has emerged as a dual-modality contrasting agent for MRI/CT imaging. 164 Dong et al 165 achieved a pioneering feat by creating an extra small contrast agent composed of ytterbium nanoparticles (YbNPs) for application in CT and spectral photon-counting computed tomography (SPECT) imaging. The YbNPs reduction is substantially higher than that of the AuNPs in the clinical X-ray energy range.…”

mentioning

confidence: 99%

Nanomaterials as Theranostic Agents for Cancer Therapy

Bauri,

Tripathi,

Choudhury

et al. 2023

ACS Appl. Nano Mater.

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“…Conventional contrasting agents typically include iodine, which is administered intravenously and can cause toxicity due to exposure to the circulatory system and cause rapid kidney excretion [ 24 ]. In the case of CT (computed tomography) imaging, conventional CAs have low efficiencies due to their energy co-efficient being outside the voltage range used in medical imaging [ 25 ]. Currently, CT imaging, alongside MRI (magnetic resonance imaging) and ultrasound are popular and clinically available imaging techniques that allow for non-invasive diagnosis by employing data based on diffusion, inflammation, and angiogenesis [ 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, CT imaging of DDS provides detailed 3D images of morphology, which displays the relationships between delivery device formulation, performance and structure [ 28 ]. Iron oxide nanoparticles (IONP) have low cytotoxicity, colloidal stability and superparamagnetic properties that enhance contrasting ability but show limited understanding of printed matrix for CT imaging [ 25 ]. As an improved alternative, iron oxide nanoparticles are encapsulated within PCL alongside TH to produce a local diagnostic real-time imaging device with fundamental requisites for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

A Refined Hot Melt Printing Technique with Real-Time CT Imaging Capability

Muldoon

Ahmad

et al. 2022

Micromachines

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Personalised drug delivery systems with the ability to offer real-time imaging and control release are an advancement in diagnostic and therapeutic applications. This allows for a tailored drug dosage specific to the patient with a release profile that offers the optimum therapeutic effect. Coupling this application with medical imaging capabilities, real-time contrast can be viewed to display the interaction with the host. Current approaches towards such novelty produce a drug burst release profile and contrasting agents associated with side effects as a result of poor encapsulation of these components. In this study, a 3D-printed drug delivery matrix with real-time imaging is engineered. Polycaprolactone (PCL) forms the bulk structure and encapsulates tetracycline hydrochloride (TH), an antibiotic drug and Iron Oxide Nanoparticles (IONP, Fe3O4), a superparamagnetic contrasting agent. Hot melt extrusion (HME) coupled with fused deposition modelling (FDM) is utilised to promote the encapsulation of TH and IONP. The effect of additives on the formation of micropores (10–20 µm) on the 3D-printed surface was investigated. The high-resolution process demonstrated successful encapsulation of both bioactive and nano components to present promising applications in drug delivery systems, medical imaging and targeted therapy.

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Solvothermal synthesis and characterization of ytterbium/iron mixed oxide nanoparticles with potential functionalities for applications as multiplatform contrast agent in medical image techniques

Cited by 8 publications

References 47 publications

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

Nanomaterials as Theranostic Agents for Cancer Therapy

A Refined Hot Melt Printing Technique with Real-Time CT Imaging Capability

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