Solving the bio-machine interface—a synthetic biology approach

Yarkoni, Orr; Frankel, Daniel

doi:10.1016/b978-0-08-100249-0.00003-3

Cited by 3 publications

(2 citation statements)

References 34 publications

(26 reference statements)

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“…We can see several examples of the creation of interfaces connecting machines and biological systems, from classic engineering biohybrid attempts (Rochford, Carnicer-Lombarte, Curto, Malliaras, & Barone, 2020) to synthetic biology approaches (Yarkoni & Frankel, 2015), such technologies have established successful bonds between the natural and artificial realms. Despite of the currently dominant neural and brain approaches (Donoghue, 2002), there are several other ways to connect machines and biological systems.…”

Section: Biological Interfacementioning

confidence: 99%

Neuropunk Revolution. Hacking Cognitive Systems towards Cyborgs 3.0

Talanov¹,

Vallverdú²,

Adamatzky³

et al. 2022

Preprint

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This work is dedicated to the review and perspective of the new direction that we call "Neuropunk revolution" resembling the cultural phenomenon of cyberpunk. This new phenomenon has its foundations in advances in neuromorphic technologies including memristive and bio-plausible simulations, BCI, and neurointerfaces as well as unconventional approaches to AI and computing in general. We present the review of the current state-of-the-art and our vision of near future development of scientific approaches and future technologies. We call the "Neuropunk revolution" the set of trends that in our view provide the necessary background for the new generation of approaches technologies to integrate the cybernetic objects with biological tissues in close loop system as well as robotic systems inspired by the biological processes again integrated with biological objects. We see bio-plausible simulations implemented by digital computers or spiking networks memristive hardware as promising bridge or middleware between digital and [neuro]biological domains.

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Section: Biological Interfacementioning

confidence: 99%

Neuropunk Revolution. Hacking Cognitive Systems towards Cyborgs 3.0

Talanov¹,

Vallverdú²,

Adamatzky³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…, the integration of biological components and artificial devices, represents a rapidly growing research field due to its numerous possible applications in biological engineering, medical treatment, wearable robotics, etc. − The bio–machine interface is considered as a bridge between tissues/cells and manmade machines, which is able to trigger and monitor the activities of biosystems simultaneously. To this end, the bio–electronic interface consisting of micro-/nanoscale electrodes has been developed to trigger and monitor electronic signals from tissues/cells with engineered surface compatibility. − It provides the possibilities to achieve real-time information exchange with biosystems, , although the electric signals of physiological processes usually accompany ion current interference arising from the antistress mechanism .…”

Section: Introductionmentioning

confidence: 99%

Optically Triggering and Monitoring Single-Cell-Level Metabolism Using Ormosil-Decorated Ultrathin Fibers

Dai

Jia

et al. 2022

Langmuir

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The integration of biological components and artificial devices requires a bio−machine interface that can simultaneously trigger and monitor the activities in biosystems. Herein, we use an organically modified silicate (ormosil) composite coating containing a light-responsive nanocapsule and a fluorescent bioprobe for reactive oxygen species (ROS) to decorate ultrathin optical fibers, namely, ormosil-decorated ultrathin fibers (OD-UFs), and demonstrate that these OD-UFs can optically trigger and monitor the intracellular metabolism activities in living cells. The sizes and shapes of UF tips were finely controlled to match the dimension and mechanical properties of living cells. The increased elasticity of the ormosil coating of OD-UFs reduces possible mechanical damage during the cell membrane penetration. The light-responsive nanocapsule was physically absorbed on the surface of the ormosil coating and could release a stimulant to trigger the metabolism activities in cells upon the guided laser through OD-UFs. The fluorescent bioprobe was covalently linked with the ormosil matrix for monitoring the intracellular ROS generation, which was verified by the in vitro experiments on the microdroplets of a hydrogen peroxide solution. Finally, we found that the living cells could maintain most of their viability after being inserted with OD-UFs, and the intracellular metabolism activities were successfully triggered and monitored at the single-cell level. The OD-UF provides a new platform for the investigation of intracellular behaviors for drug stimulations and represents a new proof of concept for a bio−machine interface based on the optical and chemical activities of organic functional molecules.

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Integrating CAx with the Chemical Synthesis for Chemical Printer Architecting in Additive Manufacturing with Logic in Materials

de Lima

2023

Preprint

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This study proposal presents a hybrid and gradual method for biologic artificialization, engineering its fundamental structure with 3D printing, conferring incremental intelligence on its superficial and deep areas for its control to classify and mimic genetic events over organic or hybrid materials. Thus, functionalized computational blocks to be used as a mechanical computer, driving materials through its most fundamental state material as computing. The route for this research is the mechanical synthesis of material computation architecture drives through quantum control in their fundamental structure using particle computational logic integration to drive molecular structures. This research aims to include the precision techniques of mechanical engineering in the biosciences, i.e., metrology and anthropometry through biometrology, to measure genetic particle components to obtain patterns, through quantum digitization to generate complex mechanical, chemical, and hybrid syntheses in the state-of-the-art for biological circuit process control. It was concluded that cutting-edge CAx intelligence for material sciences can use chemical synthesis artificially for computerizing materials for additive manufacturing.

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Solving the bio-machine interface—a synthetic biology approach

Cited by 3 publications

References 34 publications

Neuropunk Revolution. Hacking Cognitive Systems towards Cyborgs 3.0

Neuropunk Revolution. Hacking Cognitive Systems towards Cyborgs 3.0

Optically Triggering and Monitoring Single-Cell-Level Metabolism Using Ormosil-Decorated Ultrathin Fibers

Integrating CAx with the Chemical Synthesis for Chemical Printer Architecting in Additive Manufacturing with Logic in Materials

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