Abstract. After a brief discussion of the meaning of the potential in quantum mechanics, we shall examine the results of the Yukawa model (scalar meson exchange) for the nucleonnucleon interaction in three different dynamical frameworks: the non-relativistic dynamics of the Schrodinger equation, the relativistic quantum mechanics of the Bethe-Salpeter and Light-Front equations and the lattice solution of the Quantum Field Theory, obtained in the quenched approximation.