Solving a Mystery with Classical and Dual Photoredox Catalysis: Application of Nickel in the Synthesis of Ergot Alkaloids
Jan Brauer,
Rainer Wiechert,
Anika Hahn
et al.
Abstract:A short synthesis of the ergot alkaloid lysergene and
a formal
total synthesis of lysergic acid diethylamide (LSD) under the avoidance
of palladium and including two nickel-catalyzed steps instead have
been developed. A key intermediate of this approach has already been
reported by Hendrickson et al. in 2004 (Hendrickson, J.B. et al. Org. Lett.
2004, 6, 3–5),
yet the spectral data do not match, adding to doubts about the course
of their route. While the final steps of the Hendrickson synthesis
could not be rep… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.