Solvents in pesticides.

Petrelli, G; Siepi, G; Miligi, Lucia; Víneis, Paolo

doi:10.5271/sjweh.1502

Cited by 51 publications

(22 citation statements)

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“…On the other hand, interaction effects between pesticides is a likely possibility and toxicologic knowledge on this subject is very scarce (46). In addition, pesticide formulations not only include active ingredients, but also other chemicals are intentionally or unintentionally present in the pesticide formulations (47). In this study we did not specifically evaluate a potential confounding or interaction effect between pesticides or other chemicals in the formulations.…”

Section: Discussionmentioning

confidence: 97%

Paternal exposure to pesticides and congenital malformations

García¹,

Benavides²,

Fletcher³

et al. 1998

Scand J Work Environ Health

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Garcia AM, Benavides FG, Fletcher T, Orts E. Paternal exposure to pesticides and congenital malformations Scand J Work Environ Health 1998;24(6):473-480.Objectives A case-referent study with 261 matched pairs was carried out in 8 hospitals of Comunidad Valenciana, Spain, to assess the relation between occupatioilal cxposure to pesticides and selccted congenital malfor~nations. In this paper, the rcsults concerning patcnlal exposure are presented. MethodsThe parents of the case patients and the referents were interviewed to collect inforination about exposure to pesticides and potential confounding variables. Detailed information on direct involve~nent in the handling of pesticides was collected for the interviewees involved in agricultural activities during a previously defined period in relation to conception and pregnancy. Exposure data were reviewed by 2 experts who assigned ordinal scores for the probability and intensity of exposure to pesticide classes and active ingredients. ResultsThe dichotoinous analysis of exposure (absent, present) yiclded some increased risks, although not statistically significant, for aliphatic hydrocarbons [adjusted odds ratio (adjusted OR) 2.05, 95% confidence interval (95% CI) 0.62-6.801, inorganic compounds (adjusted OR 2.02, 95% CI 0.53-7.72), and glufosinate (adjusted OR 2.45, 95% CI 0.78-7.70), and a significant association for pyridil derivatives (adjusted OR 2.77, 95% CI 1.19-6.44). The analysis bascd on the experts' scores (2 levels of exposure) showed some consistent associations for these compounds.C O~~~U S~O~S This research indicates a possible risk of congenital malformations for paternal exposure to some pesticides, notably, pyridils, aliphatic hydrocarbons, inorganic compounds, and glufosinate. It did not find an increased risk for paternal exposure to pesticides in the classes of organophosphates, carbamates, organochlorines, chloroalkylthio fungicides and organosulfurs. These findings warrant further investigation.

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Section: Discussionmentioning

confidence: 97%

Paternal exposure to pesticides and congenital malformations

García¹,

Benavides²,

Fletcher³

et al. 1998

Scand J Work Environ Health

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“…Some older pesticides including organochlorines (e.g., aldrin, chlordane, DDT, dieldrin), lead arsenate, creosote, and sulfallate are carcinogenic in animal studies (98,152,153,225), and many of these pesticides continue to be used, particularly in developing countries (240). Pesticide formulations have also included carcinogenic solvents (98, 225).…”

Section: Do Pesticides Cause Cancer?mentioning

confidence: 99%

Health Effects of Chronic Pesticide Exposure: Cancer and Neurotoxicity

Alavanja

Hoppin

Kamel

2004

Annu. Rev. Public Health

620

369

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health s Abstract Pesticides are widely used in agricultural and other settings, resulting in continuing human exposure. Epidemiologic studies indicate that, despite premarket animal testing, current exposures are associated with risks to human health. In this review, we describe the routes of pesticide exposures occurring today, and summarize and evaluate the epidemiologic studies of pesticide-related carcinogenicity and neurotoxicity in adults. Better understanding of the patterns of exposure, the underlying variability within the human population, and the links between the animal toxicology data and human health effects will improve the evaluation of the risks to human health posed by pesticides. Improving epidemiology studies and integrating this information with toxicology data will allow the human health risks of pesticide exposure to be more accurately judged by public health policy makers.

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“…Significant alterations in amino acids produced clinical manifestations of ill-health in occupationally and chronically exposed agricultural workers (6). Certain cancers, namely, gastric, renal, skin and blood (leukemia and non-Hodgkin lymphoma), have tended to increase (7,8).…”

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confidence: 99%