Solventless Synthesis of Imines Derived from Diphenyldisulphide Diamine or p‐Vanillin

uppiah, Dany Jean Noël; Bhowon, Minu G.; Laulloo, Sabina Jhaumeer

doi:10.1155/2009/636707

Cited by 12 publications

(2 citation statements)

References 10 publications

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“…1) using boric acid as catalyst. It is important to mention that there are several procedures for the synthesis of imino groups which are described in the literature [15][16][17] Finally, the presence of 3 was further confirmed from mass spectrum which showed a molecular ion at m/z 312.20.…”

Section: Resultsmentioning

confidence: 86%

Design and Synthesis of Estrogen Derivative

Figueroa‐Valverde¹,

Díaz-Cedillo²,

García-Cervera³

et al. 2014

Asian J. Chem.

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Some estrogen derivatives have been developed for use in different biological and analytical methods 1-3 . For example, there are studies which show the synthesis of 2-alkylsulfanyl estrogens which are achieved by a directed ortho-lithiation reaction of suitably protected estrone followed by disulfide quench and final deprotection 4 . Other data showed the synthesis of nitrile derivatives of estrogens by reaction of 7α-cyano-19-nortestosterone with copper(II ) bromide in acetonitrile at room temperature, resulting in aromatization of the A-ring of steroid 5 . In addition, other estradiol derivative (17α-(ruthenocenylmethyl)estra-1,3,5(10)-trien-3,17β-diol) was synthetized by the reaction between 17β-spiro-oxiranyl estradiol and lithium ruthenocenyl in THF 6 . Also, several 17β-O-alkyl ethers (methyl, ethyl, propyl, butyl, hexyl and octyl) of estradiol were obtained from 3-O-benzyl-17β-estradiol with sodium hydride/ alkyl halide, followed by the removal of O-benzyl protecting group via catalytic transfer hydrogenation 7 . Additionally, there are some reports which shown the synthesis of an estradiol derivative by the Reformatsky reaction of 3,17β-bis [(2trimethylsilyl

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Section: Resultsmentioning

confidence: 86%

Design and Synthesis of Estrogen Derivative

Figueroa‐Valverde¹,

Díaz-Cedillo²,

García-Cervera³

et al. 2014

Asian J. Chem.

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“…The second stage was achieved by reaction of a brucine derivative with the compound 3 resulting in imino bond formation involved in the compound 5. It is important to mention that many procedures for the synthesis of imino groups are described in the literature [17][18][19] . In this study boric acid was used as a catalyst, because it is not an expensive reagent and no special conditions for its use are required 20 Finally, the presence of 8 was further confirmed from mass spectrum which showed a molecular ion at m/z 746.32.…”

Section: Resultsmentioning

confidence: 99%

Design and Synthesis of Two Indol-Steroid Derivatives

Figueroa‐Valverde¹,

Díaz-Cedillo²,

García-Cervera³

et al. 2014

Asian J. Chem.

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Design and synthesis of two Strychnidin‐oxiran‐naphthalenol derivatives and their theoretical evaluation as noradrenaline and serotonin reuptake inhibitors

Lauro,

Francisco,

Ricardo

et al. 2022

Vietnam Journal of Chemistry

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Several agents have been used as biogenic amine reuptake inhibitors for depression such as imipramine, fluoxetine, reboxetine, and others; however, some of these drugs can produce some secondary effects such as tiredness and psychomotor retardation. Analyzing these data, the aim of this study was to synthesize two Strychnidin‐oxiran‐naphthalenol derivatives using some chemical tools. Besides, the theoretical interaction of Strychnin‐oxiran‐naphthalenol derivatives (compounds 7 and 8) as noradrenaline and serotonin reuptake inhibitors was evaluated using two proteins (1ieo and 5i6z) as theoretical models in a docking model. The results showed a good yielding to synthesis of compounds 7 and 8. Other data suggest that either compounds 7 or 8 could interact with both 1ieo and 5i6z proteins surface, this phenomenon may be translated as changes in the biological activity of norepinephrine and serotonin reuptake. Therefore, compounds 7 and 8 could be considered two good candidates as antidepressants agents.

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Solventless Synthesis of Imines Derived from Diphenyldisulphide Diamine or p‐Vanillin

Cited by 12 publications

References 10 publications

Design and Synthesis of Estrogen Derivative

Design and Synthesis of Estrogen Derivative

Design and Synthesis of Two Indol-Steroid Derivatives

Design and synthesis of two Strychnidin‐oxiran‐naphthalenol derivatives and their theoretical evaluation as noradrenaline and serotonin reuptake inhibitors

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