Solventless convenient synthesis of new cyano-2-aminopyridine derivatives from enaminonitriles

K2CO3‐Promoted Ring‐Opening/Cyclization Reactions of Multi‐substituted Donor‐Acceptor Cyclopropanes with Thiourea: Access to 2‐Amino‐4,6‐diarylnicotinonitrile Derivatives

“…Because of inherent biological activity of 2‐aminonicotinonitrile derivatives, the construction of 2‐aminonicotinonitrile motif have been drawn numerous attentions throughout the years. A number of methods for the synthesis of substituted 2‐aminonicotinonitriles have been explored, including the mutli‐component reactions, the annulation of oxime ester, malononitrile and aldehydes, the microwave‐assisted cyclization of enaminonitriles and primary amines . Although great achievements to construct 2‐aminonicotinonitriles have been made through the multiple‐steps reaction or one‐pot mutli‐component reactions, developing an alternative method to synthesize 2‐aminonicotinonitriles and their derivatives is still highly desirable.…”

Scalable Sonochemical Synthetic Strategy for Pyrazolo[1,5-a]pyridine Derivatives: First Catalyst-Free Concerted [3 + 2] Cycloaddition of Alkyne and Alkene Derivatives to 2-Imino-1H-pyridin-1-amines

“…Sonication was performed in MKC6, Guyson ultrasonic bath (model MKC6, operating frequency of 38 kHz ± 10%, and an output power of 110 W). The arylethylidenemalononitriles 1a – g 28 and enaminonitriles 2a – g 29 were prepared according to the literature procedures.…”

Synthesis and Pharmacological Activities of Pyrano[2,3-d]pyrimidine and Pyrano[2,3-d]pyrimidine-5-one Derivatives as New Fused Heterocyclic Systems

“…Enaminonitriles have been utilized as starting materials for synthesis of huge number of heterocyclic compounds containing pyranopyrimidine [5][6][7][8][9] and pyridopyrimidine [10][11][12][13] moieties. Oxazines [14] and quinazolines [15] are natural products which exhibit a widespread spectrum of biological activity including antitumor [16][17][18], antiinflammatory [19], and antiplatelet [20] properties.…”