Solvent Magic for Organic Particles

Guo, Bing; Middha, Eshu; Liu, Bin

doi:10.1021/acsnano.9b01487

Cited by 40 publications

(39 citation statements)

References 27 publications

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“…However, it generally shows low mass production efficiency and suboptimal reproducibility with batch to batch size fluctuation . Recently, we and others have shown that microfluidics combined with nanoprecipitation offers large operation window, tunable size and morphology, good reproducibility, and scalable production of PTT agents . TA1 was therefore processed into water‐dispersible nanoparticles with DSPE‐PEG 2000 as the matrix through microfluidics combined with nanoprecipitation (Figure c) .…”

Section: Resultsmentioning

confidence: 99%

“…Recently, we and others have shown that microfluidics combined with nanoprecipitation offers large operation window, tunable size and morphology, good reproducibility, and scalable production of PTT agents . TA1 was therefore processed into water‐dispersible nanoparticles with DSPE‐PEG 2000 as the matrix through microfluidics combined with nanoprecipitation (Figure c) . To precisely control the sizes of nanoparticles, we varied Reynolds No.…”

Section: Resultsmentioning

confidence: 99%

“…Continuous synthesis by using microfluidic glass capillary mixer has gained increasing attention as they exhibit tunable physiochemical properties and efficient mixing . Due to high surface area to volume interaction, microfluidic mixers provide the benefits of enhanced and uniform mixing during NP fabrication.…”

Section: Resultsmentioning

confidence: 99%

“…They also provide precise control over the size of NPs by varying flow parameters, such as Re and inner to outer flow or velocity ratio (Figure d). The reduction in the size of NPs with Re can be attributed to the fast and uniform mixing in the microfluidic glass capillary through increasing flow rate . At Re 663, the synthesized TA1 NPs show spherical morphologies with an average diameter of around 46 and 45 nm by transmission electron microscope (TEM) and dynamic laser scattering (DLS), respectively (Figure e), which was used for further investigation in vitro and in vivo.…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Organic Small Molecule Based Photothermal Agents with Molecular Rotors for Malignant Breast Cancer Therapy

Guo

Huang

Qiu

et al. 2019

Adv Funct Materials

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Organic photothermal nanoagents are promising candidates for treating primary tumors and inhibiting metastasis. However, they often exhibit poor photostability, low absorptivity, or limited photothermal conversion efficiency (PCE). Herein, a facile molecular engineering approach to produce efficient organic photothermal molecules is demonstrated. By integrating donoracceptor structure and molecular motors, a small molecule (TA1) is synthesized with large absorptivity (22.4 L g −1 cm −1 ), negligible reactive oxygen species generation, high PCE (84.8%), excellent photothermal stability, and good biocompatibility. Furthermore, microfluidics is used to thoroughly study the relationship between the size and process conditions, yielding small uniform nanoparticles (NPs) with a diameter of 44 nm. Importantly, TA1 NPs under near-infrared laser irradiation significantly suppressed primary breast tumor growth and metastasis, both in vitro and in vivo. This study shows that small organic molecule nanoparticles are promising candidates for future cancer nanomedicine.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Organic Small Molecule Based Photothermal Agents with Molecular Rotors for Malignant Breast Cancer Therapy

Guo

Huang

Qiu

et al. 2019

Adv Funct Materials

Self Cite

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“…Same as our previous study, we have fabricated microfluidic coaxial glass capillary mixer and synthesized CP NPs at flow rate of 34 ml/min (Re 320) ( Supplementary Fig. S1 and Supplementary Equation S3) 29,30 . At Re 320, we obtained the CP NPs with an average diameter of 48 nm and polydispersity of 0.14.…”

Section: Methodsmentioning

confidence: 99%

Organic nanoparticle-doped microdroplets as dual-modality contrast agents for ultrasound microvascular flow and photoacoustic imaging

Sun

Middha

et al. 2020

Sci Rep

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Tumor blood vessels are chaotic and abundantly distributed, owing to their heterogeneity. Therefore, imaging techniques which reveal abnormalities of tumor vasculature play significant roles in both mechanistic and clinical diagnostic tumor studies. Photoacoustic (PA) imaging uses the intrinsic characteristics of hemoglobin, to acquire tumor hemodynamic information, while ultrasound (US) imaging provides information about tumoral vessel structures and blood flow. To improve the imaging contrast performance, hydrogel-based microdroplets were designed for both US blood flow and PA imaging in this study. The microdroplets served as carriers for PA contrast agent solution in the innermost part while oil and hydrogel formed the inner and outer layers of the droplets. In vitro experiments firstly demonstrated the dual modality contrast effects of the microdroplets on US flow determination and PA imaging. In vivo experiments were then carried out in both healthy nude mice and nude mice with subcutaneous tumor to validate the contrast effects and to monitor the duration of contrast effects in animals. Using the dual-modality microdroplets, we were able to obtain distinct edges of tumor and blood flow mapping of the tumor microvascular with improved sensitivity up to 11.09 dB for PA and 6.69 dB for US flow. Besides, the in vivo evaluation with microdroplets showed US flow enhancement for more than 60 min. Therefore, the microdroplets are able to provide the contrast effects for both US flow and PA in a relative long duration and have potential to be applied in the tumor related diagnoses and studies.

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Reconfigurable and Broadband Polarimetric Photodetector

Zhang

Zhu

et al. 2023

Adv Funct Materials

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The sensitive detection of light polarization besides the intensity and wavelength, can provide a new degree of freedom for more and clearer information of imaging targets in night, fog, and smoke environment. However, the conventional filter-integrated polarimetric photodetectors suffer from the complicated fabrication process and limited spectral range. Herein, broadband and polarization-sensitive photodetectors are achieved with reconfigurable operation mode, utilizing the linear dichroism and narrow band gap of 2D As 0.4 P 0.6 with in-plane anisotropic structure. In As 0.4 P 0.6 -MoTe 2 heterojunction device, both photo-gating and photovoltaic modes are operated and switchable, contributing to high responsivity (1590 A W −1 at 405 nm and 14.7 A W −1 at 1550 nm) and ultrafast speed (25 µs) in the wide spectral band (405-1550 nm). Interestingly, an optical reversal is observed on both linear dichroism and polarimetric photocurrent due to the wavelengthdependent polarization reverse nature of the As 0.4 P 0.6 flakes. The dichroism ratio of photocurrent can be modulated from unity to ≈10 by varying the gate voltage, enabling the reconfigurable detection mode from polarizationindependence to polarization-susceptibility. This study demonstrates a new prototype device comprising low symmetric van der Waals heterostructure, possessing the gate-tunability on both photo-gain and dichroism ratio, toward high performance, reconfigurable, broadband, and polarizationresolved photodetection and imaging applications.

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Solvent Magic for Organic Particles

Cited by 40 publications

References 27 publications

Organic Small Molecule Based Photothermal Agents with Molecular Rotors for Malignant Breast Cancer Therapy

Organic Small Molecule Based Photothermal Agents with Molecular Rotors for Malignant Breast Cancer Therapy

Organic nanoparticle-doped microdroplets as dual-modality contrast agents for ultrasound microvascular flow and photoacoustic imaging

Reconfigurable and Broadband Polarimetric Photodetector

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