Solvent induced conformational polymorphism

Abstract

The fact that the polymorphic outcome of crystallization is the result of the interplay between the relative thermodynamic stability and nucleation kinetics is well known. This paper presents the synthesis...

Bending the bonds: unveiling halogen interactions in the elastic polymorph of 2,5-bis(3-bromophenyl)furan

“…The data obtained underwent cell refinement, data reduction and analysis using the CrysAlisPro software (Rigaku Oxford Diffraction 2021;version 1.171.41). The crystal structures measured at room temperature were reported in our previous paper (Dyk et al, 2023). The structures presented here are measured at 100 K, which improves the data quality.…”

“…To ensure high-quality MBPF crystals, the solvent evaporation process was slowed by covering the crystallization flasks with parafilm. The complete crystallization process has been described in our previous paper (Dyk et al, 2023).…”

“…Our investigation aims to shed light on the origins of this unique elasticity, which is a property not typically associated with organic molecular crystals. Our previous studies (Dyk et al, 2023) examined the crystallographic aspects of these polymorphs, but the underlying reasons for the distinct mechanical behaviours remain enigmatic.…”

Solvent-Induced Polymorphism in a Schiff Base Compound and Their Distinguishing Effects on Semiconducting Behaviors for Utilization in Photosensitive Schottky Devices

“…Polymorphism refers to the phenomenon wherein a particular compound can exist in various crystalline structures, stemming from different arrangements of its molecules in the solid phase. − These diverse polymorphic forms of a compound are considered distinct materials, exhibiting varied physicochemical attributes. − Such differences in crystal properties within the same compound find significant applications across diverse fields, including pharmaceuticals, agrichemicals, and food additives. − However, understanding the chemical features related to intra- and intermolecular interactions that drive the existence of different polymorphic forms is equally important for fundamental research. − Polymorphism can stem from various factors, but when it arises from the presence of different conformers with distinct potential minima, which can be interconverted by a bond rotation, it is often termed conformational polymorphism. − In small organic molecules, intermolecular interactions typically do not induce noticeable alterations in bond parameters but can prompt conformational changes through torsional degrees of freedom. Consequently, directional intermolecular interactions can trigger torsional changes.…”

Solvent-induced polymorphism in dipodal N-donor ligands containing a biphenyl core

“… 5 It almost goes without saying that it is crucial to retain the same form of a drug in order not to be surprised by sudden changes in properties caused by the appearance of another form. 6 It is broadly known that various synthetic/crystallisation conditions (solvent effect, 7 the level of supersaturation, 8 temperature 9 and pressure 10 ) can lead to the occurrence of polymorphism. The phenomenon is related to the interplay of noncovalent intermolecular forces, for example hydrogen bonds, 11 halogen bonds 12 and π–π interactions, 13 different combinations of which can lead to the formation of disparate crystalline phases.…”