Solvent‐free Synthesis of Alkylaminophenols via Petasis Boronic Mannich Reaction in One Pot without Catalysts

Abstract

By using solvent-free and heat conditions, the Petasis boronic Mannich reaction of salicylaldehydes with various boronic acids and secondary amines without catalyst is described. The alkylaminophenols were obtained in moderate to good yields in a shorter reaction time than the traditional methods.

Multicomponent Petasis‐borono Mannich Preparation of Alkylaminophenols and Antimicrobial Activity Studies

“…The characterization of compounds 2 , 7 , 10 , 13 , 16 – 21 , 32 , 35 , 37 , and 42 has been previously described . Compounds 3 , 34 , and 39 have been described elsewhere . Other compounds such as 5 , 8 , 11 , 12 , 23 , and 41 have been obtained with the same spectral characterization as previously described.…”

Synthesis of Quinolines via Friedländer Reaction in Water and under Catalyst-Free Conditions

“…Over the past decades, organic reactions under catalystfree 17 and aqueous 18 conditions have increasingly caught the attention of synthetic chemists, particularly from the viewpoint of green chemistry. With respect to green chemistry, the possibility of designing catalyst-free reactions using water as a sole solvent is ideally the best choice owing to reaction efficiency, the avoidance of toxic reagents, the reduction of waste, and the responsible utilization of our resources.…”

Synthesis, spectral characterization, DFT, and molecular docking studies of 2 - ((2,3-Dihydrobenzo [b] [1,4] dioxin-6-yl) (1H-indol-1-yl) methyl) phenol compound

“…Alkylaminophenols are heterocyclic compounds containing hydroxyl and nitrogen in their structure. [1][2][3][4] It is found in the structures of drugs frequently used in cancer treatments. The compounds having antioxidant activity enables them to be used in chemotherapy.…”