Solvent-free, scalable and expeditious synthesis of benzanilides under microwave irradiation using clay doped with palladium nanoparticles as a recyclable and efficient catalyst

Dar, Bashir Ahmad; Pandey, Nalini; Singh, Snehil; Kumar, Purshotum; Farooqui, Mazahar; Singh, Baldev

doi:10.1080/17518253.2015.1065349

Cited by 8 publications

(1 citation statement)

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“…The metal doped clays can be the hybrid materials with combined catalytic rewards of metal salts and clay catalysts. Thus, in continuation of our interests [16][17][18][19][20][21], we herein report synthesis of 2H-indazoles from readily available 2-primary amines, bromobenzaldehydes and sodium azide using a heterogeneous Cu(II)/Montmorilloniteclay catalyst. The advantages of the system include, short reaction times, catalyst recyclability, neat conditions, remarkable activity without any additives and amenable for synthesis of diverse 2H-indazoles.…”

Section: Introductionmentioning

confidence: 99%

Microwave Assisted Expeditious and Green Cu(II)-Clay Catalyzed Domino One-Pot Three Component Synthesis of 2H-indazoles

Dar¹,

Safvi

Rizvi

2017

Bull. Chem. React. Eng. Catal.

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A simple and efficient synthesis of 2H-indazoles is achieved from 2-primary amines, bromobenzaldehydes and sodium azide through domino condensation, C-N and N-N bond formations, catalyzed by a heterogeneous Cu(II)-Clay catalyst. The recyclable heterogeneous Cu(II)-Clay catalyst exhibited a remarkable activity for the title reaction without any additives. An assortment of structurally diverse 2H-indazoles were prepared in good to excellent yields from easily available starting materials by using this protocol. The Cu(II)-Clay catalyst was characterized by using X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Brunauer-Emmett-Teller (BET) techniques.

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Section: Introductionmentioning

confidence: 99%

Microwave Assisted Expeditious and Green Cu(II)-Clay Catalyzed Domino One-Pot Three Component Synthesis of 2H-indazoles

Dar¹,

Safvi

Rizvi

2017

Bull. Chem. React. Eng. Catal.

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Selectfluor^TM‐Mediated Tandem Fluorination and 1,3‐Carbonyl Migration in ortho‐Carbonyl Anilines: Charge‐Transfer‐Enabled ortho‐Selectivity

2022

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An unprecedented tandem ortho‐selective fluorination and 1,3‐carbonyl migration in ortho‐carbonyl anilines using selectfluorTM as the sole reagent is reported. The reaction is transition‐metal free, does not require any pre‐functionalization, takes place under ambient conditions, and yields ortho‐fluoroanilide derivatives in moderate to good yields. SelectfluorTM serves the dual purpose of fluorine source and assists 1,3‐carbonyl migration. The formation of proposed charge transfer (CT) complex between ortho‐carbonyl aniline (donor) and selectfluorTM (acceptor), and its role in enabling the observed ortho‐selectivity is supported by experimental and computational investigations. The single‐electron‐transfer (SET) in the complex results in the formation of (2‐amino‐3‐fluorophenyl)(phenyl)methanone intermediate, which on subsequent 1,3‐carbonyl migration forms ortho‐fluoroanilide in presence of F+ or in‐situ generated H+.

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Green synthesis, inhibition studies of yeast α-glucosidase and molecular docking of pyrazolylpyridazine amines

Chaudhry

Ather

Akhtar

et al. 2017

Bioorganic Chemistry

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Solvent-free, scalable and expeditious synthesis of benzanilides under microwave irradiation using clay doped with palladium nanoparticles as a recyclable and efficient catalyst

Cited by 8 publications

References 38 publications

Microwave Assisted Expeditious and Green Cu(II)-Clay Catalyzed Domino One-Pot Three Component Synthesis of 2H-indazoles

Microwave Assisted Expeditious and Green Cu(II)-Clay Catalyzed Domino One-Pot Three Component Synthesis of 2H-indazoles

Selectfluor^TM‐Mediated Tandem Fluorination and 1,3‐Carbonyl Migration in ortho‐Carbonyl Anilines: Charge‐Transfer‐Enabled ortho‐Selectivity

Green synthesis, inhibition studies of yeast α-glucosidase and molecular docking of pyrazolylpyridazine amines

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Solvent-free, scalable and expeditious synthesis of benzanilides under microwave irradiation using clay doped with palladium nanoparticles as a recyclable and efficient catalyst

Cited by 8 publications

References 38 publications

Microwave Assisted Expeditious and Green Cu(II)-Clay Catalyzed Domino One-Pot Three Component Synthesis of 2H-indazoles

Microwave Assisted Expeditious and Green Cu(II)-Clay Catalyzed Domino One-Pot Three Component Synthesis of 2H-indazoles

SelectfluorTM‐Mediated Tandem Fluorination and 1,3‐Carbonyl Migration in ortho‐Carbonyl Anilines: Charge‐Transfer‐Enabled ortho‐Selectivity

Green synthesis, inhibition studies of yeast α-glucosidase and molecular docking of pyrazolylpyridazine amines

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Product

Resources

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Selectfluor^TM‐Mediated Tandem Fluorination and 1,3‐Carbonyl Migration in ortho‐Carbonyl Anilines: Charge‐Transfer‐Enabled ortho‐Selectivity