Solvent-Free Nuclear Magnetic Resonance Spectroscopy of Charged Molecules
Miranda N. Limbach,
Thanh D. Do
Abstract:Nuclear
magnetic resonance (NMR) spectroscopy of small molecules
protonated in a solvent-free environment was successfully demonstrated.
The method is referred to as solvent-free protonation NMR (SoF-NMR). Leveraging matrix-assisted
ionization (MAI), we generated protonated species of aniline, 4-chloroaniline,
4-aminobiphenyl, and benzocaine for NMR analysis under mild pressure
and temperature conditions. The SoF-NMR spectra were compared to traditional
solution NMR spectra, and the shift changes in nuclear sp… Show more
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