Solvent-free mechanochemical synthesis of diacylfuroxans

Selective oxidation of primary benzylic alcohols to aldehydes using NaNO3 under ball milling

“…We noticed that the nitrate/P 2 O 5 molar ratio had a strong influence on the outcome of the reactions during our exploration of these HSBM reactions. 28,32 To obtain the best yield of the product, the HSBM reaction conditions were further optimized by adjusting the molar ratio of NaNO 3 and P 2 O 5 in relation to 1a (Table 1, entries 8-15). First, in order to find a relatively good molar ratio of P 2 O 5 , the molar ratio of 1a/NaNO 3 was fixed as 1:3 and milled with different quantities of P 2 O 5 (Table 1, entries [8][9][10][11].…”

Novel Methodologies for Chemical Activation in Organic Synthesis under Solvent-Free Reaction Conditions

“…In this context, compounds of the furaxane type are of interest in organic chemistry because they are synthetic intermediates of molecules with pharmacological activity or with applications in the field of agronomy. In 2019, Guo’s group reported the synthesis of diacyl furoxanes under solvent-free reaction conditions using a high-speed ball mill ( Scheme 4 ) [ 77 ]. This methodology uses Fe(NO 3 ) 3 ∙9H 2 O as a nitrating agent and phosphorous pentoxide as an oxidant.…”

Ligand-free Pd-catalyzed highly selective arylation of activated and unactivated alkenes via oxidative and reductive heck coupling

“…Ultrasound technology has recently been applied to accelerate a large number of organic reactions under aqueous and non-aqueous conditions. 6 In particular, such techniques often provide an ameliorative, sustainable system with solvent-free conditions 7 for the improvement of traditional transformations 8 and, most importantly, alter chemical reactivity as well as selectivity. 9 The recent demand for eco-friendly chemical processes has led to the development of several clean and efficient protocols.…”