Solvent-Free Friedel–Crafts Cyclization with Trichloroacetic Anhydride

Abstract

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“Greener” Friedel−Crafts Acylations: A Metal- and Halogen-Free Methodology

“…Presumably the methanesulfonic acid generated by the reaction of the MSAA with the substrate acid is a sufficiently strong acid to catalyse the subsequent reaction of the mixed anhydride. A similar observation has been made in trichloroacetic anhydride promoted intramolecular Friedel−Crafts acylations . The ability of this methodology to deliver aryl ketones is illustrated in Table .…”