1995
DOI: 10.1080/10610279508028936
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Solvent effects on chemical processes. 9. Energetic contributions to the complexation of 4-nitroaniline with α-cyclodextrin in water and in binary aqueous-organic solvents

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Cited by 29 publications
(26 citation statements)
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“…Other phenomenological models can be found in the literature to evaluate solvent effects on complexation processes (20,21). In particular, the model of Abraham et al (20), which assumes a linear relationship between the logarithm of the association constant K and the solvophobicity parameter S p , directly related to the percent volume of organic cosolvent, is another way of managing the effect of the hydrophobicity of the medium with similar conclusions.…”
Section: Resultsmentioning
confidence: 95%
“…Other phenomenological models can be found in the literature to evaluate solvent effects on complexation processes (20,21). In particular, the model of Abraham et al (20), which assumes a linear relationship between the logarithm of the association constant K and the solvophobicity parameter S p , directly related to the percent volume of organic cosolvent, is another way of managing the effect of the hydrophobicity of the medium with similar conclusions.…”
Section: Resultsmentioning
confidence: 95%
“…6,7 One of the processes to which the theory has been applied is complex formation. 8,9 In the fully aqueous solution, our present concern, the free energy change of complex formation is given by eq 1.…”
Section: Theorymentioning
confidence: 99%
“…6,7 One of the processes to which the theory has been applied is complex formation. 8,9 In the fully aqueous solution, our present concern, the free energy change of complex formation is given by eq 1.In eq 1, ∆G* comp is given by eq 2, where K mf is the binding constant on the mole fraction scale, and the free energy change is on a per molecule basis; k and T have their usual meanings. ∆G intrasol C describes substrateligand interaction within the complex.…”
mentioning
confidence: 99%
“…As examples, we choose two drugs: the anti-inflammatory ibuprofen and antiasmatic terbutalin; the stability constants at 37°C of their complexes with -CD, obtained by applying the competitive model to the plot Correlation between log K 2 and log P 0 . The investigated alcohols (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) show very different efficiency in destabilizing the nitroxide:CD complexes. This behavior can be understood on the basis of the different tendency of these alcohols to be included in the CD cavity.…”
Section: Discussionmentioning
confidence: 99%